Protein Alignment Dic61B and dync1i2b

DIOPT Version :10

• Sequence 1: NP_728477.1
• Gene: Dic61B / 38020
• FlyBaseID: FBgn0263988
• Length: 764
• Species: Drosophila melanogaster
• Sequence 2: XP_009300385.2
• Gene: dync1i2b / 561612
• ZFINID: ZDB-GENE-090121-1
• Length: 645
• Species: Danio rerio
• Alignment Length: 743
• Identity: 148/743 - (19%)
• Similarity: 264/743 - (35%)
• Gaps: 202/743 - (27%)

  Fly    22 SNLDNELKKKSVVVNQTQAEESKAKKKDTTHYYSVETLADLQYRSQIKVLEKIYGEEVDMTPKSI 86
            |.|..||::|...:.|.: ||.|.|:::                   :..:::.|.:...:|.
Zfish     5 SELKAELERKKQRLAQIR-EEKKRKEEE-------------------RKKKELDGRKEGASPP-- 47

  Fly    87 QDDTYVEQ-----------------FMKYNLNVMHQMT-NFTTMV-------AKSTTRSRTRSSV 126
            |:|:.:|:                 .|...|.|:.:.| .|..:|       |||........|.
Zfish    48 QEDSDLERKRREAEALLQSMGITDASMVQPLRVVTEDTCLFHYLVPPPMSPSAKSVGTPSETGSQ 112

  Fly   127 RAGIGGNKQSIDDLMNGILYETINW--EPYSTVEALEEAYEPKPYTKSFLKITLRKSDF-----F 184
            .:|.||...           .|::|  :|.:.:...:......|......|:|  :.||     .
Zfish   113 DSGDGGTGP-----------RTLHWDSDPSTLLLHSDSQLGRGPLKLGMSKVT--QVDFPPKEMV 164

  Fly   185 EIHSQTQTTVAKGSPEGDDAERDNRNYEYLTIGKGKIRRRSDNDAQTDTLLFTTRAVNTILITKA 249
            ....:|||.......|.::.|.|      |.:.:..:..:.:.|:|.:
Zfish   165 SYSKETQTPTQTHHKEDEEEEED------LAVMQPVMEPQEEKDSQKE----------------- 206

  Fly   250 TVSSYVSNFEMYDTLNNITKEFATATMSSVKDLTSALAQTEDADTFEDDEAVAEKDKVSSQIERL 314
                     |...:.:.:|:|.....:.|           |:..||.|..:...:..:|.|::..
Zfish   207 ---------EDEASPHELTEEEKQQILHS-----------EEFVTFFDHSSRIMERALSEQVDVF 251

  Fly   315 FRSPEFRNAIMYMGRTLSSNTNE----AGLRRFRNFDQVERWNAEAEYVYSMNLLFRLVPEPSKD 375
            |.         |.||.|.....|    |.|...|.|.. |||:
Zfish   252 FD---------YSGRDLQDKEGESQAGAKLSLNRQFAD-ERWS---------------------- 284

  Fly   376 ERKAVSDIDFCRSNGDILAVAYGLYSFSSQHVP--TSGSVFLWSIK-NPGEPERAYYYDVPVTAI 437
            :.:.|:.:|:.....::|..:|    .|::..|  ..|...:|::| ....||..::....|.:.
Zfish   285 KHRVVTCLDWSPQYPELLVASY----CSNEEAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSA 345

  Fly   438 NFSPFLPSLLAIGLYDGSVEVRDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQVSDDDHETDID 502
            .|:.|.|:|:..|.|.|.:.:.|..|.:.|||..:..|.|..:.||..:..:.  :.:.|.
Zfish   346 AFAQFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSASAHTHPVYCVNVVG--TQNAHN---- 404

  Fly   503 PFLSLSQDGSVTRFRIIKSPFLLGFTQMILERVEGHPEGIFVHPSSRIPCESNRHPQGLSITTHP 567
             .:|:|.||.:..:    |..:|...|..||.|        ...|..:...|...|.|
Zfish   405 -LISISTDGKMCSW----SLDMLSTPQDSLELV--------FKQSKSVAVTSMSFPLG------- 449

  Fly   568 LHKDI--YYVLTDEGCIH-KCSINYQHQYLEVLRCHDGGVT---------VMEFSPWSPKLFLTC 620
               |:  :.|.:::|.:: .|....:....|:...|.|.:|         .::||    .||:|.
Zfish   450 ---DVNNFVVGSEDGSVYTACRHGSKAGISEMFEGHHGPITGLDCHTAAGPVDFS----HLFVTS 507

  Fly   621 GNDWFVRIWVDGITRPLLELLDEMTPVHWAKWSPTHSTIIVTVNR-ETANVWDFRRNLLRPMSKH 684
            ..||.|::|.....:||....|....|:...|||||..:...|:. ...::|:.......|.:..
Zfish   508 SFDWTVKLWGTKNNKPLYSFEDNSDYVYDVMWSPTHPALFACVDGVGHLDLWNLNNETEVPTASV 572

  Fly   685 KMDS--SFNTVARFSHCGRTLVIGNERG 710
            .::.  :.|.| |::|.||.:.:|:..|
Zfish   573 TVEGNPALNRV-RWAHSGREVAVGDSEG 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40 repeat	381..429	CDD:293791	10/50 (20%)
		WD40	433..711	CDD:475233	69/293 (24%)
		WD40 repeat	434..473	CDD:293791	13/38 (34%)
		WD40 repeat	552..599	CDD:293791	8/49 (16%)
		WD40	<594..>710	CDD:441893	32/127 (25%)
		WD40 repeat	604..637	CDD:293791	10/41 (24%)
		WD40 repeat	645..682	CDD:293791	9/37 (24%)
		WD40 repeat	691..727	CDD:293791	8/20 (40%)
dync1i2b	XP_009300385.2	None