DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dic61B and dync1i1

DIOPT Version :9

Sequence 1:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_009290517.1	Gene:	dync1i1 / 561525	ZFINID:	ZDB-GENE-061215-62	Length:	647	Species:	Danio rerio

Alignment Length:	738	Identity:	150/738 - (20%)
Similarity:	280/738 - (37%)	Gaps:	160/738 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SNLDNELKKKSVVVNQTQAE----ESKAKKKDTTHYYSVETL---ADL-QYRSQIKVLEKIYGEE 78
            |:|..||::|...:.|.:.|    |.:.|||::......|.:   :|| :.|.:.:.|.:..|
Zfish     5 SDLKAELERKKQRLAQIREEKKRKEEERKKKESEMLQRPENVTEDSDLDRKRRETEALLQSIG-- 67

  Fly    79 VDMTPKSIQDDTYVEQFMKYNLNVMHQMTNFTTMVAKSTTRSRTRSSVRAGIGGNKQSIDDLMNG 143
            :...|..:|.    .|.:.::....|.:.. |.|...|.:.|....:      |:::|||   .|
Zfish    68 ISPEPPLVQP----LQLLTWDTCYFHYLVP-TPMSPSSQSVSPPSET------GSQESID---GG 118

  Fly   144 IL--YETINW--EPYSTVEALEEAYE----PKPYTKSFLKITLRKSDFFEIHSQTQTTVAKGSPE 200
            .:  |.|:.|  :| |.::.|.::..    .:......::|.....:......:|||.||...||
Zfish   119 TVERYRTLQWDTDP-SALQLLADSVHGCRMQRLGASKIVQIDFMPKELVTYSKETQTPVASNQPE 182

  Fly   201 GDDAERDNRNYEYLTIGKGKIRRRSDNDAQTDTLLFTTRAVNTILITKATVSSYVSNFEMYDTLN 265
            .:|.|.       |::.|.:...:...:.:|..:    ..|:...:|.......|.
Zfish   183 EEDDEE-------LSVPKSEPASQQLEEEKTQEV----EEVHPRELTNEEKEQIVH--------- 227

  Fly   266 NITKEFATATMSSVKDLTSALAQTEDADTFEDDEAVAEKDKVSSQIERLFRSPEFRNAIMYMGRT 330
              :::|......|::.:...||  ||.|.|.|...               |..|.:...:..|..
Zfish   228 --SEDFLFFFDRSIRVVERVLA--EDKDIFFDYSG---------------RDMEDKEGDLQAGSN 273

  Fly   331 LSSNTNEAGLRRFRNFDQVERWNAEAEYVYSMNLLFRLVPEPSKDERKAVSDIDFCRSNGDILAV 395
            ||.|      |.|  :|  |.|:                      :.:.|:.:|:.....::|..
Zfish   274 LSFN------RHF--YD--EHWS----------------------KHRVVTSLDWSPQYPELLVA 306

  Fly   396 AYGLYSFSSQHVPTSGSVFLWSIK-NPGEPERAYYYDVPVTAINFSPFLPSLLAIGLYDGSVEVR 459
            :|.. :..:.|.| .|.|.:|::| ....||..::....|.::.|:.|.|:|:..|.|.|.:.:.
Zfish   307 SYNT-NEDAPHEP-DGVVLVWNMKFKKATPEYIFHCQSSVMSVGFAQFHPNLVIGGTYSGQIAMW 369

  Fly   460 DVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQVSDDDHETDIDPFLSLSQDGSVTRFRIIKSPFL 524
            |..|.:.|||..:..|.:..:.||..:..:...:.::       .:::|.||.:..:    |..:
Zfish   370 DNRSHRRTPVQRTPLSATAHTHPVYCVNVVGTQNANN-------LITVSTDGKMCSW----SLDM 423

  Fly   525 LGFTQMILERVEGHPEGIFV----HPSSRIPCESNRHPQGLSITTHPLHKDIYYVLTDEGCIHKC 585
            |...|..:|.:....:.:.|    .|:|.:                    :.|.|.::||.::..
Zfish   424 LSQPQESMELIYNKSKPVAVTCMAFPASDV--------------------NNYVVGSEEGTVYTA 468

  Fly   586 SINYQHQYL-EVLRCHDGGVT---------VMEFSPWSPKLFLTCGNDWFVRIWVDGITRPLLEL 640
            |.:.....: |:...|.|.||         .::||    .||.|...||.|::|.....:||...
Zfish   469 SRHGSKAGIGEIFDGHQGPVTGISCHNAVGPVDFS----HLFTTSSFDWTVKLWSTKHNKPLYSF 529

  Fly   641 LDEMTPVHWAKWSPTHSTIIVTVN-RETANVWDFRRNLLRPMSKHKMDS--SFNTVARFSHCGRT 702
            .|....|:...|||.|..:..||: ....::|:.......|.:...::.  :.|.| |::..||.
Zfish   530 EDNADYVYDVMWSPVHPALFATVDGNGRLDLWNLNNYTEVPSASVSVEGGCALNRV-RWASGGRE 593

  Fly   703 LVIGNERGNTLFNALNDMPFSPH 725
            :.:|:..|......:.:....||
Zfish   594 VAVGDSEGRVWIYDVGEQLAVPH 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	78/386 (20%)
		WD40 repeat	381..429	CDD:293791	11/48 (23%)
		WD40	433..711	CDD:295369	63/294 (21%)
		WD40 repeat	434..473	CDD:293791	13/38 (34%)
		WD40 repeat	552..599	CDD:293791	6/47 (13%)
		WD40 repeat	604..637	CDD:293791	11/41 (27%)
		WD40 repeat	645..682	CDD:293791	9/37 (24%)
		WD40 repeat	691..727	CDD:293791	9/35 (26%)
dync1i1	XP_009290517.1	Dynein_IC2	147..175	CDD:288403	3/27 (11%)
		WD40	215..608	CDD:225201	98/490 (20%)
		WD40	284..607	CDD:295369	77/382 (20%)
		WD40 repeat	292..337	CDD:293791	11/46 (24%)
		WD40 repeat	347..388	CDD:293791	13/40 (33%)
		WD40 repeat	394..437	CDD:293791	7/53 (13%)
		WD40 repeat	443..490	CDD:293791	12/66 (18%)
		WD40 repeat	498..530	CDD:293791	11/35 (31%)
		WD40 repeat	536..574	CDD:293791	9/37 (24%)
		WD40 repeat	582..608	CDD:293791	7/26 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810