DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dic61B and dnai4

DIOPT Version :10

Sequence 1:NP_728477.1 Gene:Dic61B / 38020 FlyBaseID:FBgn0263988 Length:764 Species:Drosophila melanogaster
Sequence 2:NP_001018595.1 Gene:dnai4 / 553797 ZFINID:ZDB-GENE-050522-322 Length:778 Species:Danio rerio


Alignment Length:711 Identity:169/711 - (23%)
Similarity:289/711 - (40%) Gaps:115/711 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   106 MTNFTTMVAKST--------TRSRTRSSVRAGIGGNKQSIDDLMNGILYETINWEPYSTVEALEE 162
            ||.|.::..::|        |||...|:..:.|....:|:.|....:|.:.......|.:::..|
Zfish   110 MTEFPSIAFQTTNASLTGPFTRSFFGSASASRISQTAESVTDETKDLLVKQDLSNSISDIQSHRE 174

  Fly   163 AYEPKPYTKSFLKITLRKSDFFEIHSQTQT------TVAKGSPEGDDAER-DNRNYEYLTIGKGK 220
              |||..    |:..:..|......|:|:|      .....|.|.:|||. ..||..|..:.|  
Zfish   175 --EPKEQ----LRENILDSTANCYLSETETIWLLDIPAVSVSLESEDAEAVKERNNAYTELCK-- 231

  Fly   221 IRRRSDNDAQTDTLLFT------TRAVNTILITKATVSSYVSNFEMYDTLNNITKEFATATMSSV 279
              .|..||...:..:.|      |:.|....||....:...:.::|||:.|||:...|...:||.
Zfish   232 --NRQGNDKYVERSMQTFSDAPKTKEVQCDSITMVDKAVMCTVWDMYDSFNNISDVSANTVVSSE 294

  Fly   280 K------------------------DLTSALAQTEDADTFEDDEAVAEKDKVSSQIERLFRSPEF 320
            :                        .:.|.::....:.|..:..|..........::.:.:|.:.
Zfish   295 RHEATIPESSPEGHLVHPKRSNQSLSVVSTVSTVSGSSTHIEKMACVLPLDEEPDLQLILQSDKL 359

  Fly   321 RNAIMYMGRTLSSNTNEAGLRRFRNFDQVERWNAEAEYVYSMNLLFRLVPEPSKDERKAVSDIDF 385
            :..:..|.|.:.:|..:..|..:|....:|          ..:.:..::.|.|..|:...|...|
Zfish   360 KQDLALMERVVLANVFQPKLAAYRQLPIIE----------DPDCVQMVMEEESWTEQSKNSHCPF 414

  Fly   386 ------------------C----RSNGDILAVAYGLYSFSSQHVPTSGSVFLWSIKNPGEPERAY 428
                              |    :.|.|:|||.||...|.:   |.||.|..||:|||..|:|.:
Zfish   415 LERLWDFSCELTMGRNVTCMVWNKKNPDLLAVGYGQVEFKN---PNSGLVCCWSLKNPTWPDRVF 476

  Fly   429 YYDVPVTAINFSPFLPSLLAIGLYDGSVEVRDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQVS 493
            |.:..|||::||....:.||:|:|||::.:.:|.:.:.||:..|....:..:|||..:.||    
Zfish   477 YCESGVTALDFSASNANQLAVGMYDGTIAIYNVQTSEQTPITDSSDCANLHTSPVWQLTWI---- 537

  Fly   494 DDDHETDI-----DPFLSLSQDGSVTRFRIIKSPFLLGFTQMILERVEGHPEGIFVHPSSRIPCE 553
              |||..:     :..:|:|.||.::::...||...:...::.:..::...     |.||..|  
Zfish   538 --DHEDGLAADKGEILVSVSSDGRISKWIHYKSMECVDLMKLKIHDLQWKQ-----HISSLTP-- 593

  Fly   554 SNRHPQGLSITTHPLHKDIYYVLTDEGCIHKCSINYQHQYLEVLRCHDGGVTVMEFSPWSPKLFL 618
                  |:....||....||.|.|:||.|||||.:|..|||:..:.|...|..:.:||:...:||
Zfish   594 ------GMCFDFHPNDSKIYLVGTEEGHIHKCSSSYNEQYLDSYKAHKRPVYKVTWSPFCSDVFL 652

  Fly   619 TCGNDWFVRIWVDGITRPLLELLDEMTPVHWAKWSPTHSTIIVTVNRETANVWDFRRNLLRPMSK 683
            :|.:||.:::|...:..|::........|....|||..:|:...|:.....:||.|.:.|.|...
Zfish   653 SCSSDWTIQLWRQDLQIPVMGFTSGQRVVFDIMWSPHCATVFGAVSEGKVEIWDLRVSSLDPTLV 717

  Fly   684 HKMDSSFN-TVARFSHCGRTLVIGNERGNTLFNALNDMPFSPHFQYDELEKAIFKAIGNDH 743
            :......| |...||.....:::|:..|......|.::......|.:.||..|...:.:.|
Zfish   718 NWTSPGVNPTALLFSPETDCVLVGDSEGQVTVYKLKNITAGGGSQGETLEDVIQSTLSSQH 778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dic61BNP_728477.1 WD40 repeat 381..429 CDD:293791 22/69 (32%)
WD40 433..711 CDD:475233 78/283 (28%)
WD40 repeat 434..473 CDD:293791 14/38 (37%)
WD40 repeat 552..599 CDD:293791 18/46 (39%)
WD40 <594..>710 CDD:441893 28/116 (24%)
WD40 repeat 604..637 CDD:293791 9/32 (28%)
WD40 repeat 645..682 CDD:293791 11/36 (31%)
WD40 repeat 691..727 CDD:293791 7/36 (19%)
dnai4NP_001018595.1 WD40 repeat 431..473 CDD:293791 18/44 (41%)
WD 1. /evidence=ECO:0000255 477..517 14/39 (36%)
WD40 479..751 CDD:475233 79/290 (27%)
WD40 repeat 483..526 CDD:293791 14/42 (33%)
WD 2. /evidence=ECO:0000255 526..573 14/52 (27%)
WD40 repeat 531..576 CDD:293791 12/50 (24%)
WD 3. /evidence=ECO:0000255 586..629 21/55 (38%)
WD40 repeat 589..624 CDD:293791 17/42 (40%)
WD 4. /evidence=ECO:0000255 633..673 11/39 (28%)
WD40 repeat 638..675 CDD:293791 10/36 (28%)
WD 5. /evidence=ECO:0000255 676..715 10/38 (26%)
WD40 repeat 681..707 CDD:293791 7/25 (28%)
WD 6. /evidence=ECO:0000255 721..760 7/38 (18%)

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