DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dic61B and dnai4

DIOPT Version :9

Sequence 1:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001018595.1	Gene:	dnai4 / 553797	ZFINID:	ZDB-GENE-050522-322	Length:	778	Species:	Danio rerio

Alignment Length:	711	Identity:	169/711 - (23%)
Similarity:	289/711 - (40%)	Gaps:	115/711 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 MTNFTTMVAKST--------TRSRTRSSVRAGIGGNKQSIDDLMNGILYETINWEPYSTVEALEE 162
            ||.|.::..::|        |||...|:..:.|....:|:.|....:|.:.......|.:::..|
Zfish   110 MTEFPSIAFQTTNASLTGPFTRSFFGSASASRISQTAESVTDETKDLLVKQDLSNSISDIQSHRE 174

  Fly   163 AYEPKPYTKSFLKITLRKSDFFEIHSQTQT------TVAKGSPEGDDAER-DNRNYEYLTIGKGK 220
              |||..    |:..:..|......|:|:|      .....|.|.:|||. ..||..|..:.|
Zfish   175 --EPKEQ----LRENILDSTANCYLSETETIWLLDIPAVSVSLESEDAEAVKERNNAYTELCK-- 231

  Fly   221 IRRRSDNDAQTDTLLFT------TRAVNTILITKATVSSYVSNFEMYDTLNNITKEFATATMSSV 279
              .|..||...:..:.|      |:.|....||....:...:.::|||:.|||:...|...:||.
Zfish   232 --NRQGNDKYVERSMQTFSDAPKTKEVQCDSITMVDKAVMCTVWDMYDSFNNISDVSANTVVSSE 294

  Fly   280 K------------------------DLTSALAQTEDADTFEDDEAVAEKDKVSSQIERLFRSPEF 320
            :                        .:.|.::....:.|..:..|..........::.:.:|.:.
Zfish   295 RHEATIPESSPEGHLVHPKRSNQSLSVVSTVSTVSGSSTHIEKMACVLPLDEEPDLQLILQSDKL 359

  Fly   321 RNAIMYMGRTLSSNTNEAGLRRFRNFDQVERWNAEAEYVYSMNLLFRLVPEPSKDERKAVSDIDF 385
            :..:..|.|.:.:|..:..|..:|....:|          ..:.:..::.|.|..|:...|...|
Zfish   360 KQDLALMERVVLANVFQPKLAAYRQLPIIE----------DPDCVQMVMEEESWTEQSKNSHCPF 414

  Fly   386 ------------------C----RSNGDILAVAYGLYSFSSQHVPTSGSVFLWSIKNPGEPERAY 428
                              |    :.|.|:|||.||...|.:   |.||.|..||:|||..|:|.:
Zfish   415 LERLWDFSCELTMGRNVTCMVWNKKNPDLLAVGYGQVEFKN---PNSGLVCCWSLKNPTWPDRVF 476

  Fly   429 YYDVPVTAINFSPFLPSLLAIGLYDGSVEVRDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQVS 493
            |.:..|||::||....:.||:|:|||::.:.:|.:.:.||:..|....:..:|||..:.||
Zfish   477 YCESGVTALDFSASNANQLAVGMYDGTIAIYNVQTSEQTPITDSSDCANLHTSPVWQLTWI---- 537

  Fly   494 DDDHETDI-----DPFLSLSQDGSVTRFRIIKSPFLLGFTQMILERVEGHPEGIFVHPSSRIPCE 553
              |||..:     :..:|:|.||.::::...||...:...::.:..::...     |.||..|
Zfish   538 --DHEDGLAADKGEILVSVSSDGRISKWIHYKSMECVDLMKLKIHDLQWKQ-----HISSLTP-- 593

  Fly   554 SNRHPQGLSITTHPLHKDIYYVLTDEGCIHKCSINYQHQYLEVLRCHDGGVTVMEFSPWSPKLFL 618
                  |:....||....||.|.|:||.|||||.:|..|||:..:.|...|..:.:||:...:||
Zfish   594 ------GMCFDFHPNDSKIYLVGTEEGHIHKCSSSYNEQYLDSYKAHKRPVYKVTWSPFCSDVFL 652

  Fly   619 TCGNDWFVRIWVDGITRPLLELLDEMTPVHWAKWSPTHSTIIVTVNRETANVWDFRRNLLRPMSK 683
            :|.:||.:::|...:..|::........|....|||..:|:...|:.....:||.|.:.|.|...
Zfish   653 SCSSDWTIQLWRQDLQIPVMGFTSGQRVVFDIMWSPHCATVFGAVSEGKVEIWDLRVSSLDPTLV 717

  Fly   684 HKMDSSFN-TVARFSHCGRTLVIGNERGNTLFNALNDMPFSPHFQYDELEKAIFKAIGNDH 743
            :......| |...||.....:::|:..|......|.::......|.:.||..|...:.:.|
Zfish   718 NWTSPGVNPTALLFSPETDCVLVGDSEGQVTVYKLKNITAGGGSQGETLEDVIQSTLSSQH 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	107/399 (27%)
		WD40 repeat	381..429	CDD:293791	22/69 (32%)
		WD40	433..711	CDD:295369	78/283 (28%)
		WD40 repeat	434..473	CDD:293791	14/38 (37%)
		WD40 repeat	552..599	CDD:293791	18/46 (39%)
		WD40 repeat	604..637	CDD:293791	9/32 (28%)
		WD40 repeat	645..682	CDD:293791	11/36 (31%)
		WD40 repeat	691..727	CDD:293791	7/36 (19%)
dnai4	NP_001018595.1	WD40 repeat	431..473	CDD:293791	18/44 (41%)
		WD40	<459..754	CDD:225201	90/313 (29%)
		WD 1. /evidence=ECO:0000255	477..517		14/39 (36%)
		WD40	479..751	CDD:295369	79/290 (27%)
		WD40 repeat	483..526	CDD:293791	14/42 (33%)
		WD 2. /evidence=ECO:0000255	526..573		14/52 (27%)
		WD40 repeat	531..576	CDD:293791	12/50 (24%)
		WD 3. /evidence=ECO:0000255	586..629		21/55 (38%)
		WD40 repeat	589..624	CDD:293791	17/42 (40%)
		WD 4. /evidence=ECO:0000255	633..673		11/39 (28%)
		WD40 repeat	638..675	CDD:293791	10/36 (28%)
		WD 5. /evidence=ECO:0000255	676..715		10/38 (26%)
		WD40 repeat	681..707	CDD:293791	7/25 (28%)
		WD 6. /evidence=ECO:0000255	721..760		7/38 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576716
Domainoid	1	1.000	111	1.000	Domainoid score	I6196
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11702
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4110
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310818at33208
OrthoFinder	1	1.000	-	-		FOG0006125
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5769
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.890