DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dic61B and Dnai1

DIOPT Version :10

Sequence 1:NP_728477.1 Gene:Dic61B / 38020 FlyBaseID:FBgn0263988 Length:764 Species:Drosophila melanogaster
Sequence 2:NP_001019513.1 Gene:Dnai1 / 500442 RGDID:1565671 Length:705 Species:Rattus norvegicus


Alignment Length:772 Identity:164/772 - (21%)
Similarity:314/772 - (40%) Gaps:166/772 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 ELKKKSVVVNQTQAEESKAKKKDTTHYYSVETLAD--LQYRSQIKVLEKIYGEEVDM-------- 81
            :::|:||::.:      .|:|::......|...||  .|.::.::..:::...:.::        
  Rat     5 QIRKQSVILTR------GARKREEDSGTDVGEGADDWAQSKAAVRPPDQLELTDAELKEEFTRIL 63

  Fly    82 ------TPKSIQDDTYVEQFMKYNLNVMHQMT-NFT---TMVAKSTTRSRTRSSVRAGIGGNKQS 136
                  .|::|...::.|:..|. :..::||. :|:   .::.|.:...|.:......:.|:::|
  Rat    64 TANNPHAPQNIVRYSFKERTYKL-IGFVNQMAIHFSQVGNLIPKDSDEGRRQHYRDELVAGSQES 127

  Fly   137 IDDLMNGILYETINWEPYSTVEALEEAYEPKPYTKSFLKITLRKSDFFEIHSQTQTTVAKGSPEG 201
            :..:.             |..|.|||..|||                            :|..||
  Rat   128 VKVVT-------------SDTEILEEEEEPK----------------------------EGEGEG 151

  Fly   202 D-DAERDNRNYEYLTIGKGKIRRRSDNDAQTDTLLFTTRAVNTILIT------KATVSSYVSNFE 259
            : :||           |:.:...::|..|..:|   |.:.:...|:.      :...:.:..:..
  Rat   152 EGEAE-----------GEAEAGSQTDVPAAAET---TEKVIEEELMAPVQPKERKLTNQFNFSER 202

  Fly   260 MYDTLNNITKEFATATMSSVKDLTSALA-QTEDADTFEDD----EAVAEKDKVSSQIERLFRSPE 319
            ...|.||..::.........:...||.| |.|..|.:.|:    |...||:|..:.:.:......
  Rat   203 ASQTFNNPLRDRECQMEPPPRTNFSATANQWEIYDAYVDELEKLEKTKEKEKTKTPVAKKTEKMA 267

  Fly   320 FR----------------NAIMYMGRTLSSNTNEAGLRRFRNFDQVERWNAEAEYVYSMNLLFRL 368
            .|                .|...:.|.::.||.:...:.|:.::     :|..||......|..|
  Rat   268 MRKLTSMESQSDDITKVTQAAKIVERMVNQNTYDDVAQDFKYYE-----DAADEYRDQEGTLLPL 327

  Fly   369 VP-EPSKDERKAVSDIDFCRSNGDILAVAYGLYSFSSQHVPTSGSVFLWSIKNPGEPERAYYYDV 432
            .. :..|.:|.||:.:.:.....|:.||.:|.|.|..|   :.|.:.|:|:|||..||..:..:.
  Rat   328 WKFQNDKAKRLAVTALCWNPKYKDLFAVGHGSYDFMKQ---SRGMLLLYSMKNPSFPEYMFSSES 389

  Fly   433 PVTAINFSPFLPSLLAIGLYDGSVEVRDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQVSDDDH 497
            .:..::.....|.|:.:|.|||:|.:.::......|...|...:...:.||..::|  |..|.||
  Rat   390 GIMCLDMHMDHPYLVVVGYYDGNVAIYNLKKPHSQPCFRSTSKSGKHTDPVWQVKW--QKDDMDH 452

  Fly   498 ETDIDPFLSLSQDGSVTRFRIIKSPFLLGFTQMILERVEGH----PEGIFVHPSSRIPCESNRHP 558
            ..:   |.|:|.||.:..:.::||.  |....:|..:.||.    |||:.:|   .:.|.     
  Rat   453 NLN---FFSVSSDGRIVSWTLVKSE--LVHIDVIKLKDEGSTTEIPEGLQLH---TVGCG----- 504

  Fly   559 QGLSITTHPLHKDIYYVL---TDEGCIHKCSINYQHQYLEVLRCHDGGVTVMEFSPWSPKLFLTC 620
                 |....||:|.|:.   |:||.|:|||.:|..|:|:....|:..|..:.::|:..::|::|
  Rat   505 -----TAFDFHKEIDYLFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMAVDAVLWNPYHARVFISC 564

  Fly   621 GNDWFVRIWVDGITRPLLELLDEMTPVHWAKWSPTHSTIIVTVNRE-TANVWDFRRNLLRPM--- 681
            .:||.|:||...|..|:. :.|....|....|:|..||:...|..: .|:|:|...|....:   
  Rat   565 SSDWTVKIWDHAIKTPMF-IYDLNAAVGDVAWAPYSSTVFAAVTTDGKAHVFDLAVNKYEAICNQ 628

  Fly   682 -----SKHKMDSSFNTVARFSHCGRTLVIGNERGNTLFNALNDMPFSPHFQYDELEK 733
                 .|:|:     |..:|:.....:::|::||:     :..:..||:.:....||
  Rat   629 PVVAKKKNKI-----THVQFNPIHPIIIVGDDRGH-----ITCLKLSPNLRKMPKEK 675

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dic61BNP_728477.1 WD40 repeat 381..429 CDD:293791 15/47 (32%)
WD40 433..711 CDD:475233 76/293 (26%)
WD40 repeat 434..473 CDD:293791 8/38 (21%)
WD40 repeat 552..599 CDD:293791 16/49 (33%)
WD40 <594..>710 CDD:441893 29/124 (23%)
WD40 repeat 604..637 CDD:293791 10/32 (31%)
WD40 repeat 645..682 CDD:293791 10/45 (22%)
WD40 repeat 691..727 CDD:293791 7/35 (20%)
Dnai1NP_001019513.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44 9/44 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 122..169 17/98 (17%)
WD40 repeat 340..386 CDD:293791 16/48 (33%)
WD40 <358..616 CDD:475233 80/281 (28%)
WD 1 386..426 7/39 (18%)
WD40 repeat 392..433 CDD:293791 9/40 (23%)
WD 2 435..478 15/49 (31%)
WD40 repeat 440..494 CDD:293791 17/60 (28%)
WD40 repeat 505..542 CDD:293791 15/36 (42%)
WD 3 543..583 12/40 (30%)
WD40 repeat 548..587 CDD:293791 12/39 (31%)
WD 4 585..625 11/39 (28%)
WD40 repeat 590..631 CDD:293791 10/40 (25%)
WD 5 633..672 9/48 (19%)

Return to query results.
Submit another query.