DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dic61B and Dnai1

DIOPT Version :9

Sequence 1:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001019513.1	Gene:	Dnai1 / 500442	RGDID:	1565671	Length:	705	Species:	Rattus norvegicus

Alignment Length:	772	Identity:	164/772 - (21%)
Similarity:	314/772 - (40%)	Gaps:	166/772 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ELKKKSVVVNQTQAEESKAKKKDTTHYYSVETLAD--LQYRSQIKVLEKIYGEEVDM-------- 81
            :::|:||::.:      .|:|::......|...||  .|.::.::..:::...:.::
  Rat     5 QIRKQSVILTR------GARKREEDSGTDVGEGADDWAQSKAAVRPPDQLELTDAELKEEFTRIL 63

  Fly    82 ------TPKSIQDDTYVEQFMKYNLNVMHQMT-NFT---TMVAKSTTRSRTRSSVRAGIGGNKQS 136
                  .|::|...::.|:..|. :..::||. :|:   .::.|.:...|.:......:.|:::|
  Rat    64 TANNPHAPQNIVRYSFKERTYKL-IGFVNQMAIHFSQVGNLIPKDSDEGRRQHYRDELVAGSQES 127

  Fly   137 IDDLMNGILYETINWEPYSTVEALEEAYEPKPYTKSFLKITLRKSDFFEIHSQTQTTVAKGSPEG 201
            :..:.             |..|.|||..|||                            :|..||
  Rat   128 VKVVT-------------SDTEILEEEEEPK----------------------------EGEGEG 151

  Fly   202 D-DAERDNRNYEYLTIGKGKIRRRSDNDAQTDTLLFTTRAVNTILIT------KATVSSYVSNFE 259
            : :||           |:.:...::|..|..:|   |.:.:...|:.      :...:.:..:..
  Rat   152 EGEAE-----------GEAEAGSQTDVPAAAET---TEKVIEEELMAPVQPKERKLTNQFNFSER 202

  Fly   260 MYDTLNNITKEFATATMSSVKDLTSALA-QTEDADTFEDD----EAVAEKDKVSSQIERLFRSPE 319
            ...|.||..::.........:...||.| |.|..|.:.|:    |...||:|..:.:.:......
  Rat   203 ASQTFNNPLRDRECQMEPPPRTNFSATANQWEIYDAYVDELEKLEKTKEKEKTKTPVAKKTEKMA 267

  Fly   320 FR----------------NAIMYMGRTLSSNTNEAGLRRFRNFDQVERWNAEAEYVYSMNLLFRL 368
            .|                .|...:.|.::.||.:...:.|:.::     :|..||......|..|
  Rat   268 MRKLTSMESQSDDITKVTQAAKIVERMVNQNTYDDVAQDFKYYE-----DAADEYRDQEGTLLPL 327

  Fly   369 VP-EPSKDERKAVSDIDFCRSNGDILAVAYGLYSFSSQHVPTSGSVFLWSIKNPGEPERAYYYDV 432
            .. :..|.:|.||:.:.:.....|:.||.:|.|.|..|   :.|.:.|:|:|||..||..:..:.
  Rat   328 WKFQNDKAKRLAVTALCWNPKYKDLFAVGHGSYDFMKQ---SRGMLLLYSMKNPSFPEYMFSSES 389

  Fly   433 PVTAINFSPFLPSLLAIGLYDGSVEVRDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQVSDDDH 497
            .:..::.....|.|:.:|.|||:|.:.::......|...|...:...:.||..::|  |..|.||
  Rat   390 GIMCLDMHMDHPYLVVVGYYDGNVAIYNLKKPHSQPCFRSTSKSGKHTDPVWQVKW--QKDDMDH 452

  Fly   498 ETDIDPFLSLSQDGSVTRFRIIKSPFLLGFTQMILERVEGH----PEGIFVHPSSRIPCESNRHP 558
            ..:   |.|:|.||.:..:.::||.  |....:|..:.||.    |||:.:|   .:.|.
  Rat   453 NLN---FFSVSSDGRIVSWTLVKSE--LVHIDVIKLKDEGSTTEIPEGLQLH---TVGCG----- 504

  Fly   559 QGLSITTHPLHKDIYYVL---TDEGCIHKCSINYQHQYLEVLRCHDGGVTVMEFSPWSPKLFLTC 620
                 |....||:|.|:.   |:||.|:|||.:|..|:|:....|:..|..:.::|:..::|::|
  Rat   505 -----TAFDFHKEIDYLFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMAVDAVLWNPYHARVFISC 564

  Fly   621 GNDWFVRIWVDGITRPLLELLDEMTPVHWAKWSPTHSTIIVTVNRE-TANVWDFRRNLLRPM--- 681
            .:||.|:||...|..|:. :.|....|....|:|..||:...|..: .|:|:|...|....:
  Rat   565 SSDWTVKIWDHAIKTPMF-IYDLNAAVGDVAWAPYSSTVFAAVTTDGKAHVFDLAVNKYEAICNQ 628

  Fly   682 -----SKHKMDSSFNTVARFSHCGRTLVIGNERGNTLFNALNDMPFSPHFQYDELEK 733
                 .|:|:     |..:|:.....:::|::||:     :..:..||:.:....||
  Rat   629 PVVAKKKNKI-----THVQFNPIHPIIIVGDDRGH-----ITCLKLSPNLRKMPKEK 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	101/388 (26%)
		WD40 repeat	381..429	CDD:293791	15/47 (32%)
		WD40	433..711	CDD:295369	76/293 (26%)
		WD40 repeat	434..473	CDD:293791	8/38 (21%)
		WD40 repeat	552..599	CDD:293791	16/49 (33%)
		WD40 repeat	604..637	CDD:293791	10/32 (31%)
		WD40 repeat	645..682	CDD:293791	10/45 (22%)
		WD40 repeat	691..727	CDD:293791	7/35 (20%)
Dnai1	NP_001019513.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		9/44 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..169		17/98 (17%)
		WD40	325..683	CDD:225201	101/385 (26%)
		WD40 repeat	340..386	CDD:293791	16/48 (33%)
		WD40	<358..616	CDD:295369	80/281 (28%)
		WD 1	386..426		7/39 (18%)
		WD40 repeat	392..433	CDD:293791	9/40 (23%)
		WD 2	435..478		15/49 (31%)
		WD40 repeat	440..494	CDD:293791	17/60 (28%)
		WD40 repeat	505..542	CDD:293791	15/36 (42%)
		WD 3	543..583		12/40 (30%)
		WD40 repeat	548..587	CDD:293791	12/39 (31%)
		WD 4	585..625		11/39 (28%)
		WD40 repeat	590..631	CDD:293791	10/40 (25%)
		WD 5	633..672		9/48 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310818at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9130
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820