DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dic61B and dync2i2

DIOPT Version :9

Sequence 1:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_012823678.1	Gene:	dync2i2 / 448417	XenbaseID:	XB-GENE-953027	Length:	503	Species:	Xenopus tropicalis

Alignment Length:	408	Identity:	90/408 - (22%)
Similarity:	160/408 - (39%)	Gaps:	72/408 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 FDQVE-RWNAEAEYVYSMNLLFRLVPEPSKDERKAVSDIDFCRSNGDILAVAYGLY-----SFSS 404
            ||..| .|..:.|.|..::.|  ..|: :.:::..|:.:.: .|.|.|:|.:||.:     |...
Frog    99 FDGYEVNWEEQHEQVTCLHSL--QYPD-ALEQQLQVTSVSW-NSTGSIIACSYGRFGDGDWSTEK 159

  Fly   405 QHVPTSGSVFLWSIK----NPGEPERAYYYDVP--VTAINFSPFLPSLLAIGLYDGSVEVRDVSS 463
            .:|.|      |::.    |...|:..  .|||  |..:.:.|..|||:|.||::|.|.|.|.|.
Frog   160 SYVCT------WNLDRRGFNANNPDTV--LDVPSSVMCLAWHPSQPSLIAGGLFNGDVLVWDTSR 216

  Fly   464 LQDTPVAVSQRSTSPGSSPVVAIRWIKQVSDDDHETDIDPFLSLSQDGSVTRFRIIKSPFLL--- 525
            ..|..:..:.......:..|..:.|:::.| ..|...:   .|:|.||.:..:::.|...|:
Frog   217 TDDPLIGRTGHVGDTHTDAVYQVGWMQEKS-QGHRHQV---FSVSSDGKILVWQMEKEGHLVLLD 277

  Fly   526 GFTQMILERVEGHPEGIFVHPSSR------IPCESNRHPQGLSITTHPLHKDIYYVLTDEGCIHK 584
            ||. ::.:::   |....:|...|      :.|.|..|          ....::.|..:.|.:.|
Frog   278 GFA-LVAQQI---PSNTKIHKPGRGDTAVGVTCLSYSH----------FDPSLFIVGVEGGYLLK 328

  Fly   585 CSINYQ----------------HQYLEVLRCHDGGVTVMEFSPWSPKLFLTCGNDWFVRIWVDGI 633
            ||.:.|                .|:  ....|.|.|..:..||:...|||:.|.|....::....
Frog   329 CSSSVQTLAPINMGSSVPLRAPAQF--TFSPHGGPVYSVTCSPFHRNLFLSAGTDGHAHLYSMLQ 391

  Fly   634 TRPLLELLDEMTPVHWAKWSPTHSTIIVTVNRETANVW-DFRRNLLRPMSKHKMDSSFNTV--AR 695
            .:||:.|......:...:|||....:....:.:...|. ||.::..:|....|..:|...|  ..
Frog   392 AKPLVSLQLSQKYLFSIRWSPVRPLVFAAASGDGEVVLVDFAKSFQKPSLCIKQTASGRPVYCLE 456

  Fly   696 FSHCGRTLVIGNERGNTL 713
            |:|....|:...:...|:
Frog   457 FNHAQSQLLAAGDGTGTV 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	85/395 (22%)
		WD40 repeat	381..429	CDD:293791	12/56 (21%)
		WD40	433..711	CDD:295369	66/307 (21%)
		WD40 repeat	434..473	CDD:293791	14/38 (37%)
		WD40 repeat	552..599	CDD:293791	10/62 (16%)
		WD40 repeat	604..637	CDD:293791	8/32 (25%)
		WD40 repeat	645..682	CDD:293791	7/37 (19%)
		WD40 repeat	691..727	CDD:293791	5/25 (20%)
dync2i2	XP_012823678.1	WD40 repeat	131..182	CDD:293791	13/59 (22%)
		WD40	184..481	CDD:392136	67/311 (22%)
		WD40 repeat	188..227	CDD:293791	13/38 (34%)
		WD40 repeat	236..297	CDD:293791	14/68 (21%)
		WD40 repeat	305..355	CDD:293791	10/61 (16%)
		WD40 repeat	362..399	CDD:293791	10/36 (28%)
		WD40 repeat	405..446	CDD:293791	8/40 (20%)
		WD40 repeat	452..477	CDD:293791	5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910