DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dic61B and sw

DIOPT Version :9

Sequence 1:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster

Alignment Length:	763	Identity:	140/763 - (18%)
Similarity:	268/763 - (35%)	Gaps:	221/763 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ELKKKSVVVNQTQAEESKAKKKDTTHYYSVETLADLQYRSQIKVLEKIYGE-----EVDMTPKSI 86
            ||::|...:...:.|:.:.:::                 .:||.:|:..|.     .:|...:..
  Fly     6 ELERKKAKLAALREEKDRRRRE-----------------KEIKDMEEAAGRIGGGAGIDKDQRKD 53

  Fly    87 QDDTYVEQFMKYNLNVMHQMTNFTTMVAKSTTRSRTRSSVRAGI----GGNKQSIDDLMNGILYE 147
            .|:......:.....|:..:::..:|.:.::......:|::|.:    ||.||.::..:..:  :
  Fly    54 LDEMLSSLGVAPVSEVLSSLSSVNSMTSDNSNTQTPDASLQATVNGQSGGKKQPLNLSVYNV--Q 116

  Fly   148 TINWEPYSTVEALEEAYEPKPYTKSFLKITLRKSDFFEIHSQTQTTVAKGSPEGDDAERDNRNYE 212
            ..|..|..|:          .|||                 ||||| :.|...||
  Fly   117 ATNIPPKETL----------VYTK-----------------QTQTT-STGGGNGD---------- 143

  Fly   213 YLTIGKGKIRRRSDNDAQTDTLLFTTRAVNTILITKATVSSYVSNF---------EMYD------ 262
                                          .:....:.:|.|:.::         :.||
  Fly   144 ------------------------------VLSCHSSPLSGYMEDWWRPRKAHATDYYDEYNLNP 178

  Fly   263 --------------TLNNITKEFA--------TATMSSVKDLTSALAQTEDADTFEDDEAVAEKD 305
                          :|.|:...|.        |..:.:|||:..|:...|.....|..:.|.|..
  Fly   179 GLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVAPAITPLEIKKETEVKKEVNELS 243

  Fly   306 KVSSQIERLFRSPEFRNAIMYMGRTLSSNTNEAGLRRFRNFD---------QVERWNAEAEYV-Y 360
            :...|:  :..|..|:..::..||.:....:|       |.|         ..|..|.|..:. .
  Fly   244 EEQKQM--IILSENFQRFVVRAGRVIERALSE-------NVDIYTDYIGGGDSEEANDERSHARL 299

  Fly   361 SMNLLFRLVPEPSKDER----KAVSDIDFCRSNGDILAVAYGLYSFSSQHVPT--SGSVFLWSIK 419
            |:|.:|       .|||    :.::.:|:.....:::..:|    .:::..|.  .|.|.:|:.|
  Fly   300 SLNRVF-------YDERWSKNRCITSMDWSTHFPELVVGSY----HNNEESPNEPDGVVMVWNTK 353

  Fly   420 -NPGEPERAYYYDVPVTAINFSPFLPSLLAIGLYDGSVEVRDVSSLQDTPVAVSQRSTSPGSSPV 483
             ....||..::....|.:..|:.|.|:|:..|.|.|.:.:.|....:.||:..:..|.:..:.||
  Fly   354 FKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPV 418

  Fly   484 VAIRWIKQVSDDDHETDIDPFLSLSQDGSVTRFRIIKSPFLLGFTQMILERVEGHPEGIFVHPSS 548
            ..::.:.  :.:.|..     :|:|.||.:..:    |..:|...|..||..:...:.|.: .|.
  Fly   419 YCLQMVG--TQNAHNV-----ISISSDGKLCSW----SLDMLSQPQDTLELQQRQSKAIAI-TSM 471

  Fly   549 RIPC-ESNRHPQGLSITTHPLHKDIYYVLTDEGCIHKCS-------INYQHQYLEVLRCHDGGVT 605
            ..|. |.|....|                :::|.::..|       :|      ||...|.|.:|
  Fly   472 AFPANEINSLVMG----------------SEDGYVYSASRHGLRSGVN------EVYERHLGPIT 514

  Fly   606 VM-----EFSPWSPKLFLTCGNDWFVRIWVDGITRPLLELLDEMTPVHWAKWSPTHSTIIVTVNR 665
            .:     :.||....||||...||.:::|....|:||....|....|....|||.|..:...|:.
  Fly   515 GISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDG 579

  Fly   666 E-TANVWDFRRNLLRPMSKHKMDS--SFNTVARFSHCGRTLVIGNERG 710
            . ..::|:..::...|.:...:..  :.|.|: ::..|..:.||:|.|
  Fly   580 SGRLDLWNLNQDTEVPTASIVVAGAPALNRVS-WTPSGLHVCIGDEAG 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	81/377 (21%)
		WD40 repeat	381..429	CDD:293791	9/50 (18%)
		WD40	433..711	CDD:295369	66/294 (22%)
		WD40 repeat	434..473	CDD:293791	11/38 (29%)
		WD40 repeat	552..599	CDD:293791	8/54 (15%)
		WD40 repeat	604..637	CDD:293791	11/37 (30%)
		WD40 repeat	645..682	CDD:293791	8/37 (22%)
		WD40 repeat	691..727	CDD:293791	7/20 (35%)
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922	9/56 (16%)
		WD40	316..632	CDD:421866	75/350 (21%)
		WD40 repeat	316..365	CDD:293791	9/52 (17%)
		WD40 repeat	371..409	CDD:293791	10/37 (27%)
		WD40 repeat	418..457	CDD:293791	9/49 (18%)
		WD40 repeat	469..555	CDD:293791	25/107 (23%)
		WD40 repeat	561..599	CDD:293791	8/37 (22%)
		WD40 repeat	607..633	CDD:293791	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435307
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840