DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dic61B and CG15701

DIOPT Version :9

Sequence 1:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_611100.1	Gene:	CG15701 / 36801	FlyBaseID:	FBgn0034095	Length:	1051	Species:	Drosophila melanogaster

Alignment Length:	756	Identity:	141/756 - (18%)
Similarity:	259/756 - (34%)	Gaps:	225/756 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SSNLDNELKKKSVVVNQTQAEESKAKKKDTTHYYSVETLADLQYRSQIKVLEKIYGEEV-DMTPK 84
            |.|:..|:.:|   |.::.|....|..:::.           :.||..|..:.:.||:: ..|..
  Fly    10 SKNVKTEVPRK---VTKSPATSGPATTRESK-----------ERRSLAKQPDSLEGEKIARKTTT 60

  Fly    85 SIQDDTYVEQFMKYNLN---------------VMHQMTNFTTMVAKSTTRSRTRSSVRAGIGGNK 134
            :.|..|..::.:....|               .:...|..||.......:|:|..:.:.......
  Fly    61 AAQPTTASKKPLATGKNKERESLSKRTTPSPGALRATTRHTTTTTNPPLQSKTTKTTKLVAKSKP 125

  Fly   135 QSIDDLMNGILYETINWEPYS-TVEALEEAYEPKPYTKSFLKITLRKSDFFEIHSQTQTTVAKGS 198
            .::.|..:.:   |:...|.. ..:|.:|...|.|.:|.:..:           :|||......|
  Fly   126 NAVLDTYHSV---TVASPPQKRRGQAEQEKESPTPSSKEYSPV-----------AQTQKEHKPQS 176

  Fly   199 PEGDDAE---RDNRNY-------EYLTIGKGKIRRRSDNDAQ-----TDTLLFTTRAVNTILITK 248
            |...||.   ..:|.|       |.:.:.:...::||:.:|:     ...:.|..: .:.....:
  Fly   177 PSKGDARIVPARSRTYTRTLDPEEVVILKRESAKQRSEVEAKESEPVKQPVAFEVK-FDEAKKPE 240

  Fly   249 ATVSSYVSNFEMYDTLNNITKEFAT--ATMSSV-----KDLTSALAQTEDADTFEDDE------A 300
            .....|..:||.|::      :|.|  :|...|     ::.:|:.|:.|:....||.|      .
  Fly   241 PESDHYSDDFESYES------DFETDASTPDEVESDEAQEPSSSEAEVEEEREEEDSEPTQNPIT 299

  Fly   301 VAEKDKVSSQIERLFRSPEFRNAIMYMGRT-LSSNTNEAGLRRFRNFDQVERWNAEAEYVYSMNL 364
            |.::||   ..||...|..:.   |::.|. |||.:.:   .::.:||.....|:|
  Fly   300 VIQRDK---DQERKLDSGHYD---MHLRRNPLSSLSTQ---NQYDSFDTNSMANSE--------- 346

  Fly   365 LFRLVPEPSKDERKAVSDIDFCRSNGDILAVAYGLYS-FSSQHVPTSGSVFLWSIKNPGEP---- 424
                    ..|...:.:.::..|| |: ..|.||.|| |.|..|          |...||.
  Fly   347 --------QLDSGISTTGVEKPRS-GE-ANVYYGGYSGFVSHPV----------ISRRGEELMAK 391

  Fly   425 ---ERAYYYDVPVTAINFSPFLPSLLAIGLYDGSVEVRDVSSLQDTP--------VAVSQRSTSP 478
               ::..|:...:..:::..|:.|.       |.:....|::...:|        :.|..||:..
  Fly   392 LRFDQLNYHLFEMKPLSYEGFMQSY-------GKLNASQVATQTQSPHMDGECQTLEVHSRSSWT 449

  Fly   479 GSSP------VVAI--------RWIKQVSDDDHETDIDPF-----LSLSQDGSVTRFRIIKSPFL 524
            ...|      |::.        .|.||.: |::|..|...     |..::...:.:.|:.||
  Fly   450 QHPPHYGGQFVLSCSVDAELDETWSKQPA-DEYEASISRLEQLHRLEQARSQQLQQKRLAKS--- 510

  Fly   525 LGFTQMILERVEGHPEGIFVHPSSR-----IPCESNRHPQGLSITTHPLHKDIYYVL-------- 576
                 ..|||:..     |:|.:.|     :..::..|.||.|....||...:...|
  Fly   511 -----TDLERLNS-----FLHRAGRLMGLVLEGKTTAHGQGNSPRNVPLQTGLLNALPVRRIFGS 565

  Fly   577 TDEG----CIHKCSIN---YQHQYLEVLRCHDGGVTVMEFSPWSPKLFLTCGNDWFVRIWVDGIT 634
            ...|    .:|:|..:   |:..:..:|         |.:|..:|                   :
  Fly   566 AGNGQLVVTVHECPADSNVYKEDFASLL---------MVWSLANP-------------------S 602

  Fly   635 RPLLELLDEMTPVHWAKWSPTHSTIIVTVNRE-TANVWDFR 674
            :| |.||.....|.....|.....|:|...|: :..:||.|
  Fly   603 QP-LRLLSTWAEVSRVALSAQAQDIVVAGLRDGSVAMWDLR 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	69/373 (18%)
		WD40 repeat	381..429	CDD:293791	14/55 (25%)
		WD40	433..711	CDD:295369	53/290 (18%)
		WD40 repeat	434..473	CDD:293791	6/46 (13%)
		WD40 repeat	552..599	CDD:293791	12/61 (20%)
		WD40 repeat	604..637	CDD:293791	3/32 (9%)
		WD40 repeat	645..682	CDD:293791	8/31 (26%)
		WD40 repeat	691..727	CDD:293791
CG15701	NP_611100.1	PTZ00108	<23..270	CDD:240271	46/278 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000