DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dic61B and Dnai2

DIOPT Version :9

Sequence 1:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001007727.1	Gene:	Dnai2 / 360654	RGDID:	1359602	Length:	619	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	118/546 - (21%)
Similarity:	207/546 - (37%)	Gaps:	120/546 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 YLTIGK----GKIRRRSDNDAQTD---------TLLFTTR-AVNTILITKATVSSYVSNFEMYDT 263
            |:.:.|    ||....||..|:.:         ..|:..| .|:|.:...|::|.:.:|.|.:
  Rat     5 YVYVKKRSEFGKQCNFSDRQAELNIDISPNPELAALYVERNPVDTGIQCSASMSEHEANTERF-- 67

  Fly   264 LNNITKEFATATMSSVKDLTSALAQTEDADTFEDDEAVAEKDKVSSQIERLFRSPEFRNAIMYMG 328
                  |.....::.|:.     ...:|.:..|.::.:..:.||.       :...:.||:|.:|
  Rat    68 ------EMENCGVNHVEG-----GWPKDVNPQELEQTIRFRKKVE-------KDENYINAVMQLG 114

  Fly   329 RTL-----SSNTNEAGLRRFRNFDQVERWNAEAEYVYSMNLLFRLVPEPSKDERKAVSDIDFCRS 388
            ..:     .:|..:.....|.:.:.|| ...||....::| :||   :|.:.:|.| :.:.:...
  Rat   115 SIMEHCIKQNNAIDIYEEYFDDEEAVE-VTEEAPSAKTIN-VFR---DPQEIKRTA-THLSWHPD 173

  Fly   389 NGDILAVAYGLYSFSSQHVPTSGSVFLWSIKNPGEPERAYYYDVPVTAINFSPFLPSLLAIGLYD 453
            ....|||||....|....:..|...::|.::||..||.|.....|:..:.::|....:|..|.|:
  Rat   174 GNKKLAVAYSCLQFQRSPMGMSHDSYIWDLENPNRPEIALKPSSPLITLEYNPKDSHVLLGGCYN 238

  Fly   454 GSVEVRDV--SSLQDTPVAVSQRSTSPGS--SPVVAIRWIKQVSDDDHETDIDPFLSLSQDGSVT 514
            |.:...|.  .||      |::.||...|  .||....|::.      :|..:.| |.|.||.|.
  Rat   239 GQIACWDTRKGSL------VAELSTIEFSHRDPVYGTIWLQS------KTGTECF-SASTDGQVM 290

  Fly   515 --RFRIIKSPFLLGFTQMIL------ERVEGHPEGIFVHPSSRIPCESNRHPQGLSITTHPLHKD 571
              ..|.|..|     |::::      |::|.....|.:...|.:|.:
  Rat   291 WWDIRKISEP-----TEVVIMDITRKEQLENALGAISLEFESTLPTK------------------ 332

  Fly   572 IYYVLTDEGCIHKCSINYQHQYLEVLRC----HDGGVTVMEFSPWSPKLFLTCGNDWFVRIWVDG 632
             :.|.|::|.:..|:...:.. .|.:.|    |.|.:..::.:|:.||.|||.| ||..|||.:.
  Rat   333 -FMVGTEQGIVISCNRKAKTP-AEKIVCTFSGHHGPIYALQRNPFYPKNFLTVG-DWAARIWSEE 394

  Fly   633 ITRPLLELLDEMTPVHWAK----------WSPTHSTIIVTVNRE-TANVWDFRRNLLRPMSKHKM 686
                     ...:.:.|.:          |||....:..|...: |.::||.......|....|:
  Rat   395 ---------SRESSIMWTRYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPALSLKV 450

  Fly   687 DSSFNTVARFSHCGRTLVIGNERGNT 712
            ........|....|..:..|:|.|.|
  Rat   451 CDDPLFCLRVQDTGCLIACGSELGTT 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	87/382 (23%)
		WD40 repeat	381..429	CDD:293791	13/47 (28%)
		WD40	433..711	CDD:295369	66/304 (22%)
		WD40 repeat	434..473	CDD:293791	9/40 (23%)
		WD40 repeat	552..599	CDD:293791	5/46 (11%)
		WD40 repeat	604..637	CDD:293791	12/32 (38%)
		WD40 repeat	645..682	CDD:293791	9/47 (19%)
		WD40 repeat	691..727	CDD:293791	6/22 (27%)
Dnai2	NP_001007727.1	WD40 repeat	165..212	CDD:293791	13/47 (28%)
		WD40	<166..489	CDD:225201	81/359 (23%)
		WD40	166..472	CDD:295369	78/353 (22%)
		WD 1	214..254		10/45 (22%)
		WD40 repeat	220..259	CDD:293791	11/44 (25%)
		WD 2	261..302		14/52 (27%)
		WD40 repeat	266..361	CDD:293791	24/126 (19%)
		WD40 repeat	318..347	CDD:293791	7/47 (15%)
		WD 3	362..401		14/48 (29%)
		WD40 repeat	367..403	CDD:293791	12/45 (27%)
		WD 4	405..445		7/39 (18%)
		WD40 repeat	410..435	CDD:293791	5/24 (21%)
		WD 5	450..489		6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	566..619
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810