Protein Alignment Dic61B and Dnai3

DIOPT Version :10

• Sequence 1: NP_728477.1
• Gene: Dic61B / 38020
• FlyBaseID: FBgn0263988
• Length: 764
• Species: Drosophila melanogaster
• Sequence 2: NP_001128208.1
• Gene: Dnai3 / 292165
• RGDID: 1563105
• Length: 921
• Species: Rattus norvegicus
• Alignment Length: 864
• Identity: 159/864 - (18%)
• Similarity: 274/864 - (31%)
• Gaps: 320/864 - (37%)

  Fly     8 TVTSQENGSIFKRSSNLDNELKKKSVVVNQTQAEESKAKKKDTTHYYSVETLADLQYRSQI---- 68
            |..:||   ||  :..:|.::         |..:..|..||:       :.|||||.|:.:
  Rat    48 TAKTQE---IF--NCRIDEDM---------TDEQTYKLIKKE-------DILADLQNRAAVSDFH 91

  Fly    69 ---KVLEKIYGEEVDMTPKSIQDDTYVEQFMKYNLNVMHQMTNFTTMVAKSTTRSRTRSSVRAGI 130
               |::.:..|||:.:        .|.:.| ||.||..                          :
  Rat    92 PVKKIVLEYPGEELLL--------VYDKDF-KYGLNFY--------------------------L 121

  Fly   131 GGNKQSIDDLMNGILYETINWEPYSTVEALEE---AYEPKPYTKSFLKITLRKSDFFEIHSQTQT 192
            .|.::..::.:..   ..|..|.....|.:.|   .|:| |.:|.::.:...|    ||
  Rat   122 IGTEEGKENFLKA---PEIPEEQEDLKEHVPEDVYIYKP-PVSKPWISLGSEK----EI------ 172

  Fly   193 TVAKGSPEGDDAERDNRNYEYLTIGKGKIRRRSDNDAQTDTLLFTTRAVNTILITKATV--SSYV 255
                   |.:..:...:...|:.     .|:||...|..     |.|..|...:..|.:  :||.
  Rat   173 -------EEESVQESKKRVTYMI-----SRKRSQFGAPV-----TFRDQNASSVKDAYIECTSYP 220

  Fly   256 SNFEMYDTLNNITKEFATATMSSVKDLT---------SALAQTEDADTFEDDEAVAEKDK----- 306
            .  :.| ||..:.|:.....::.|||.:         :|..|....:..|:::.|..:.|
  Rat   221 D--KSY-TLTQVEKDIGLQVIAEVKDTSTQTRWAFPRNATTQYYPREFSEEEKNVLVESKSLAEF 282

  Fly   307 ---VSSQIERLFRSPEFRNAIMYMGRTLSSNTNEAG------LRRFRNFDQVER----------W 352
               ||:.:|...:..|..|......|:|:...:..|      |:.:::|..:..          |
  Rat   283 FSTVSTSVEIALQQNEIMNTFTDDWRSLAEEESTFGDKTDTHLKEYQSFTDLHNTMEKMITCVSW 347

  Fly   353 N------------AEAEYVYSMNLLFRLVPEPSKDERKAVSD----------------IDFCRSN 389
            :            ....|...:....||:.:||.....:.||                .:||.|:
  Rat   348 HPTIYGLIVVSVAVRLSYEERVQNSSRLLLQPSLILFWSFSDPIHPQLMLESPDDIFCFEFCPSD 412

  Fly   390 GDILAVAYGLYSFSSQHVPTSGSVFLW----------SIKNPG--------------EP----ER 426
            .:|:|...           .:|.:.||          :||..|              ||    |.
  Rat   413 PNIIAGGC-----------INGQIILWDITAHAERIENIKTGGSRSKKATLKPMFLLEPDSNKEI 466

  Fly   427 AYYYDVPVTAINFS--------PFLPSLLAIGLYDGSVEVRDVSSLQ------------------ 465
            .|.....|::|...        .:||....|.......|.|...:.|
  Rat   467 MYVRHCAVSSIENGHRKVITDIHWLPDSFEINRMGSVFENRSGINCQLITCSADCTICFWDIRPQ 531

  Fly   466 -------DTPVAVSQRSTSPGSSPV--------------------VAIRW--IKQVSDDDHETDI 501
                   .|....|..:|:|...|.                    :.:.|  :.::.....||.:
  Rat   532 KPTVTSAATATTTSTTNTNPQQPPAEKKKEESIEIPFDVPSTFLHLDLSWKPLSRIKLSKGETSL 596

  Fly   502 D---PFLSLSQDGSVTRFRIIKSPFLL----GFTQM-ILERVEGHP----EGIFVHPSSRIPCES 554
            |   ..|||.:|.::.:.:...|..:|    ..:|| :|:..|.:|    ||
  Rat   597 DHCPTKLSLGEDPALCKIQGTSSIHVLLRDKMLSQMKLLKAAEINPYQNLEG------------- 648

  Fly   555 NRHPQGLSITTHPLH--KDIYYVLTDEGCIHKCSINYQHQYLE---------------VLRCHDG 602
                 |::....|:.  :..::|.|:||     .:.|....:|               :...|||
  Rat   649 -----GMANMLKPIEDFRTKFFVGTEEG-----EVIYTDWKMERDSETGRLMAKKPVNLYTVHDG 703

  Fly   603 GVTVMEFSPWSPKLFLTCGNDWFVRIWVDGI-TRPLLELL---DEMTPVHWAKWSPTHSTIIVTV 663
            .|..::.||:...:.||.|. |.|.||.:.: |.|||:..   ...|..||:...|.    :..:
  Rat   704 AVHTVQRSPFFNDIILTVGG-WNVAIWKEEVLTGPLLQTCCAPKRYTAGHWSLTRPG----VFYI 763

  Fly   664 NRET--ANVWDFRRNLLRP 680
            .||.  .::||.......|
  Rat   764 GREDGYVDIWDLLEKTHEP 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40 repeat	381..429	CDD:293791	16/91 (18%)
		WD40	433..711	CDD:475233	64/338 (19%)
		WD40 repeat	434..473	CDD:293791	9/71 (13%)
		WD40 repeat	552..599	CDD:293791	8/63 (13%)
		WD40	<594..>710	CDD:441893	27/108 (25%)
		WD40 repeat	604..637	CDD:293791	11/33 (33%)
		WD40 repeat	645..682	CDD:293791	9/38 (24%)
		WD40 repeat	691..727	CDD:293791
Dnai3	NP_001128208.1	WD40	479..527	CDD:197651	6/47 (13%)