DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dic61B and DNAI1

DIOPT Version :9

Sequence 1:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001268357.1	Gene:	DNAI1 / 27019	HGNCID:	2954	Length:	703	Species:	Homo sapiens

Alignment Length:	756	Identity:	165/756 - (21%)
Similarity:	282/756 - (37%)	Gaps:	250/756 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SQENGSIFKRSSNLDNELKKKSVVV---NQTQAEESKAKKKDTTHYYSVETLADLQYRSQIKVLE 72
            |||:..:...:.||:.:.:.|.:..   :||....:.|.:|.|
Human   135 SQESVKVISETGNLEEDEEPKELETEPGSQTDVPAAGAAEKVT---------------------- 177

  Fly    73 KIYGEEVDMTPKSIQDDTYVEQFMKYNLNVMHQMTNFTTMVAKSTTR------------SRTRSS 125
                ||..||||..::.....||            ||:...:::...            .||..|
Human   178 ----EEELMTPKQPKERKLTNQF------------NFSERASQTYNNPVRDRECQTEPPPRTNFS 226

  Fly   126 VRAGIGGNKQSIDDLMNGILYETINWEPYST-VEALEEAYEPKPYTKSFLKITLRKSDFFEIHSQ 189
            ..|.                    .||.|.. ||.||:..:.|...|:
Human   227 ATAN--------------------QWEIYDAYVEELEKQEKTKEKEKA----------------- 254

  Fly   190 TQTTVAKGSPEGDDAERDNRNYEYLTIGKGKIRRRSDNDAQTDTLLFTTRAVNTILITKATVSSY 254
             :|.|||.|                  ||..:|:.:..::|||.|:..::|        |.:...
Human   255 -KTPVAKKS------------------GKMAMRKLTSMESQTDDLIKLSQA--------AKIMER 292

  Fly   255 VSNFEMYDTLNNITKEFATATMSSVKDLTSALAQTEDADTFEDDEAVAEKDKVSSQIERLFRSPE 319
            :.|...||   :|.::|                      .:.||.|...:|:|.:.:.
Human   293 MVNQNTYD---DIAQDF----------------------KYYDDAADEYRDQVGTLLP------- 325

  Fly   320 FRNAIMYMGRTLSSNTNEAGLRRFRNFDQVER-------WNAEAEYVYSMNLLFRLVPEPSKDER 377
                                |.:|:| |:.:|       ||.:          :|
Human   326 --------------------LWKFQN-DKAKRLSVTALCWNPK----------YR---------- 349

  Fly   378 KAVSDIDFCRSNGDILAVAYGLYSFSSQHVPTSGSVFLWSIKNPGEPERAYYYDVPVTAINFSPF 442
                         |:.||.||.|.|..|   :.|.:.|:|:|||..||..:..:..|..::....
Human   350 -------------DLFAVGYGSYDFMKQ---SRGMLLLYSLKNPSFPEYMFSSNSGVMCLDIHVD 398

  Fly   443 LPSLLAIGLYDGSVEVRDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQVSDDDHETDIDPFLSL 507
            .|.|:|:|.|||:|.:.::......|...|...:...|.||..::|.|    ||.:.::: |.|:
Human   399 HPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQK----DDMDQNLN-FFSV 458

  Fly   508 SQDGSVTRFRIIKSPFLLGFTQMILERVEGH----PEGIFVHPSSRIPCESNRHPQGLSITTHPL 568
            |.||.:..:.::|..  |....:|..:|||.    |||:.:||   :.|.          |....
Human   459 SSDGRIVSWTLVKRK--LVHIDVIKLKVEGSTTEVPEGLQLHP---VGCG----------TAFDF 508

  Fly   569 HKDIYYVL---TDEGCIHKCSINYQHQYLEVLRCHDGGVTVMEFSPWSPKLFLTCGNDWFVRIWV 630
            ||:|.|:.   |:||.|:|||.:|..|:|:....|:..|..:.::|:..|:|::|.:||.|:||.
Human   509 HKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWD 573

  Fly   631 DGITRPLLELLDEMTPVHWAKWSPTHSTIIVTVNRE-TANVWDFRRNLLRPMSKHKMDSSFN--T 692
            ..|..|:. :.|..:.|....|:|..||:...|..: .|:::|...|....:....:.:..|  |
Human   574 HTIKTPMF-IYDLNSAVGDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKNRLT 637

  Fly   693 VARFSHCGRTLVIGNERGNTLFNALNDMPFSPHFQYDELEK 733
            ..:|:.....:::|::||:.:     .:..||:.:....||
Human   638 HVQFNLIHPIIIVGDDRGHII-----SLKLSPNLRKMPKEK 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	98/381 (26%)
		WD40 repeat	381..429	CDD:293791	16/47 (34%)
		WD40	433..711	CDD:295369	78/287 (27%)
		WD40 repeat	434..473	CDD:293791	10/38 (26%)
		WD40 repeat	552..599	CDD:293791	16/49 (33%)
		WD40 repeat	604..637	CDD:293791	11/32 (34%)
		WD40 repeat	645..682	CDD:293791	9/37 (24%)
		WD40 repeat	691..727	CDD:293791	8/37 (22%)
DNAI1	NP_001268357.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..174		6/29 (21%)
		WD40	324..681	CDD:225201	107/440 (24%)
		WD 1	324..374		18/113 (16%)
		WD40 repeat	339..385	CDD:293791	19/81 (23%)
		WD40	<357..615	CDD:295369	83/281 (30%)
		WD 2	379..417		11/37 (30%)
		WD40 repeat	391..428	CDD:293791	9/36 (25%)
		WD 3	426..469		13/47 (28%)
		WD40 repeat	439..496	CDD:293791	19/63 (30%)
		WD 4	478..530		21/64 (33%)
		WD40 repeat	504..541	CDD:293791	15/36 (42%)
		WD 5	535..574		13/38 (34%)
		WD40 repeat	547..584	CDD:293791	12/37 (32%)
		WD 6	578..616		9/38 (24%)
		WD40 repeat	589..616	CDD:293791	7/26 (27%)
		WD 7	622..662		6/44 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5611
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310818at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770