Protein Alignment Dic61B and Dnai4

DIOPT Version :10

• Sequence 1: NP_728477.1
• Gene: Dic61B / 38020
• FlyBaseID: FBgn0263988
• Length: 764
• Species: Drosophila melanogaster
• Sequence 2: XP_036020022.1
• Gene: Dnai4 / 242584
• MGIID: 2385328
• Length: 812
• Species: Mus musculus
• Alignment Length: 840
• Identity: 197/840 - (23%)
• Similarity: 329/840 - (39%)
• Gaps: 179/840 - (21%)

  Fly     5 VRNTVTSQENGSIFKRSSNLDNELKKKSV-VVNQTQAEESKAKKKDTTHYYSVET----LADLQY 64
            :.::.||....:.|..|::..   .:||: .:|.:::...|.......:..:|..    |.|::.
Mouse     1 MHSSPTSTRKQASFAASASAQ---PRKSISFINPSKSSAGKGYAASNPNKLAVSRTMGFLTDMKP 62

  Fly    65 RSQI-----KVLEKIYGEEVDMTPK-----------------------SIQDDTYVEQFMKYNLN 101
            ..::     |.::.:..:.||:||:                       |:..| |:..:..|
Mouse    63 AEKLNVPSAKTVQVLDSKGVDVTPRPLYHPDPHAASAKPNKLLTSQEGSLGSD-YISSYSLY--- 123

  Fly   102 VMHQMTNFTTMVAKSTTRSRTRSSVRAGIGGNKQSIDDLMNGILYETINWEPYSTVEALE---EA 163
               |.|...:|:.:.|......|||........:|:.:.:....|:......::.|..|.   ||
Mouse   124 ---QNTLNPSMLGQYTRSVLGSSSVSKSSISTTESMSEDLEDSSYKRDRLASFTDVRVLRSTAEA 185

  Fly   164 YEPKPYTKSFLKITLRKSD---FFEIHSQTQTTVAKGSPEGDDAER---DNRNYEYLTIGKGKIR 222
            ...|...:..::|.|.:::   ||::.:...:|      |.::||:   .|:.||.|      .|
Mouse   186 AISKEELEKTIEIILTETETLRFFDLPTVMFST------ESEEAEKIIEKNKKYETL------CR 238

  Fly   223 RRSDNDAQTDTLLFT---------TRAVNTILITKATVSSYVSNFEMYDTLNNITKEFATATMSS 278
            .|..||...:.::.|         .:....||..|..|:   :.:::||:. ||.:....|..|.
Mouse   239 NRLGNDLYVERMMQTFNGAPKNKEVQCEKIILEEKGVVA---TTWDLYDSY-NIPETLLAAKRSG 299

  Fly   279 --------VKDLTSALAQTEDADTFEDDEAVAEK--DKVSSQIERLFRSPEFRNAIMYMGRTLSS 333
                    .||....:..:|.:...:.:..:..|  :......|.:.:|.:....:.||.|.|..
Mouse   300 YSSKGSLPAKDRDPKIQDSESSSLMDIENVILAKVQEDEEDNSEAILKSDKLHQDLFYMERVLME 364

  Fly   334 NTNEAGLRRFRNFD--------------QVERWNA-------EAEYVYSMNLLFRLVPE----PS 373
            |..:..|..:|...              |||....       |.|....|.|...:..|    |:
Mouse   365 NVFQPKLAAYRQLPVYKEHEPEEPEETLQVENLKVAEDEPKKEDEEEVEMELELEIATEQSTIPA 429

  Fly   374 KDER-----------KAVSDIDFCRSNGDILAVAYGLYSFSSQHVPTSGSVFLWSIKNPGEPERA 427
            ..||           ..||.:.:.::|.|:|||.||.:.|..|   ..|....||||||..|||.
Mouse   430 NLERLWSFSCDLTKGLNVSSLSWNKANPDLLAVGYGNFGFREQ---KKGMACCWSIKNPMWPERI 491

  Fly   428 YYYDVPVTAINFSPFLPSLLAIGLYDGSVEVRDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQ- 491
            |.....||:::||...|:|||:|.::|:|.:.:|.|..:.||..|..|......||..::||:|
Mouse   492 YQSSYGVTSVDFSNSSPNLLAVGYHNGTVAIYNVQSSHNIPVLDSSESPQKHLGPVWQVQWIEQD 556

  Fly   492 ---VSDDDHETDIDPFLSLSQDGSVTRFRIIKSPFLLGFTQMILERVEGHPEGIFVHPSSRIPCE 553
               ..||..|.    .:|:|.||.::::.|.|                    |:..|...|:...
Mouse   557 RGTTGDDKREI----LVSISADGRISKWIIRK--------------------GLDCHDLMRLKRT 597

  Fly   554 S------------------NRHPQGLSITTHPLHKDIYYVLTDEGCIHKCSINYQHQYLEVLRCH 600
            :                  :|...|:....||...:||...|:||.|||||.:|..||||..|.|
Mouse   598 TATGGKKGGEKEKKGEALISRQAPGMCFAFHPKDTNIYLAGTEEGLIHKCSCSYNEQYLETYRGH 662

  Fly   601 DGGVTVMEFSPWSPKLFLTCGNDWFVRIWVDGITRPLLELLDEMTPVHWAKWSPTHSTIIVTVNR 665
            .|.|..:.::|:.|.:||:|..||.|.||.....:|.|........|:...|||..:.|....|.
Mouse   663 KGPVYKVTWNPFCPDVFLSCSADWGVMIWHQDTVKPFLSFYPTTYVVYDVSWSPKSAYIFAAANE 727

  Fly   666 ETANVWDFRRNLLRPMSKHKMDS--SFNTV--ARFSHCGRTLVIGNERGNTLFNALNDMP 721
            ....:||.:.:.|.|:..:..:.  .|.||  |:.:.|   |::|:..|......|.:||
Mouse   728 NRVEIWDLQISTLDPLIVNVANPGIKFTTVLFAKETDC---LLVGDSDGQVAVYELRNMP 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40 repeat	381..429	CDD:293791	20/47 (43%)
		WD40	433..711	CDD:475233	86/303 (28%)
		WD40 repeat	434..473	CDD:293791	15/38 (39%)
		WD40 repeat	552..599	CDD:293791	19/64 (30%)
		WD40	<594..>710	CDD:441893	35/119 (29%)
		WD40 repeat	604..637	CDD:293791	11/32 (34%)
		WD40 repeat	645..682	CDD:293791	10/36 (28%)
		WD40 repeat	691..727	CDD:293791	10/33 (30%)
Dnai4	XP_036020022.1	WD40 repeat	448..493	CDD:293791	20/47 (43%)
		WD40	<480..782	CDD:441893	98/328 (30%)
		WD40 repeat	498..542	CDD:293791	17/43 (40%)
		WD40 repeat	548..617	CDD:293791	15/92 (16%)
		WD40 repeat	622..660	CDD:293791	18/37 (49%)
		WD40 repeat	667..702	CDD:293791	12/34 (35%)
		WD40 repeat	709..741	CDD:293791	8/31 (26%)
		WD40 repeat	751..780	CDD:293791	8/31 (26%)