DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dic61B and Dnai3

DIOPT Version :9

Sequence 1:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_766452.2	Gene:	Dnai3 / 242253	MGIID:	3045269	Length:	923	Species:	Mus musculus

Alignment Length:	923	Identity:	161/923 - (17%)
Similarity:	295/923 - (31%)	Gaps:	345/923 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 NQTQAEESKAKKKDTTHYYSVETLADLQYRSQI-------KVLEKIYGEEVDMTPKSIQDDTYVE 93
            :.|..:..|..||:       :.|||||.|:.:       |::.:..|||:.:        .|.:
Mouse    62 DMTDEQTYKLIKKE-------DILADLQNRAAVSDFHPVKKIVREYPGEELLL--------VYDK 111

  Fly    94 QFMKYNLNVMHQMTNFTTMVAKSTTRSRTRSSVRAGIGGNKQSIDDLMNGILYETINWEPYSTVE 158
            .| ||.||..                          :.|.:...::.:..........||...|:
Mouse   112 DF-KYGLNFY--------------------------LIGTEDGKENFLKPPEVPEEQEEPKEHVQ 149

  Fly   159 ALEEAYEPKPYTKSFLKITLRKSDFFEIHSQTQTTVAKGSPEGDDAERDNRNYEYLTIGKGKIRR 223
            .....|.| |.:|.::.:...|    ||             |.:..:...:...|:.     .|:
Mouse   150 EDVYVYNP-PVSKPWVSLGSEK----EI-------------EEESVQESGKRVTYMI-----SRK 191

  Fly   224 RSDNDAQTDTLLFTTRAVNTILITKATVSSYVSNFEMYDTLNNITKEFATATMSSVKDLT----- 283
            ||:..|   .:.|:.:..:::.......:||.   |...||:.:.|:.....::.|||.:
Mouse   192 RSEFGA---PVTFSDQNASSVKDAYIECTSYP---EKNYTLSQVEKDVGLQVIAEVKDTSTQTKW 250

  Fly   284 ----SALAQTEDADTFEDDEAVAEKDK--------VSSQIERLFRSPEFRNAIMYMGRTLSSNTN 336
                :|..|....:..|:::::..|.|        ||:.:|...:..|..|..:...:.|:...:
Mouse   251 AFPKNATTQYYPREFSEEEKSLIGKSKSLVDFFNNVSTSVEVALQQNEIMNTFIDDWKNLAEEES 315

  Fly   337 EAG------LRRFRNFDQVERWNAEAEYVYSMN---LLFRLVPEPSKDERKAVSDIDFCRSNGDI 392
            ..|      |:.:::|..:.  |...:.:..::   .:|.|:                      :
Mouse   316 TFGDKTDTHLKEYQSFTDLH--NTMEKMITCVSWHPTIFGLI----------------------V 356

  Fly   393 LAVAYGLYSFSSQHVPTSGSVFL-------WSIKNPGEPERAYYYDVPVTAINFSPFLPSLLAIG 450
            ::||..| |: .:.|..||.:.|       ||..:|..|:........:....|.|..|:::|.|
Mouse   357 VSVAVRL-SY-EERVQNSGRLLLQPSLLLFWSFSDPIHPQLMLESPDDIFCFEFCPSDPNIIAGG 419

  Fly   451 LYDGSVEVRDVSSLQD-----------------TPV-----------------AVSQRSTSPGSS 481
            ..:|.:.:.|:::..|                 .|:                 |||  |...|..
Mouse   420 CINGQIVLWDITAHADRIENIKTGGHRSKKTSLKPMFLLEPDSNKESMYIRHCAVS--SIENGHR 482

  Fly   482 PVVA-IRWI-------------------------------------------------------- 489
            .|:. |.|:
Mouse   483 KVITDIHWLPDSFEINRMGSVFENRSGINCQLVTCSADCTICFWDIRPQKPAVTAAAAASAATTA 547

  Fly   490 -----KQVS--DDDHETDID-PF------------------LSLSQ-----DGSVTRFRIIKSPF 523
                 .|.|  :...|.:|| ||                  |.||:     |...|:..:.:.||
Mouse   548 TNNANSQQSPVEKKKEENIDIPFDVPSTFLHLDLSWKPLSRLKLSKGDTSLDHCPTKLSLGEDPF 612

  Fly   524 LLGFTQMILERVEGHPEGIFVH--------------PSSRIPCESNRHPQGLSITTHPLHKDI-- 572
            |.        :::|...   :|              .:|.|....|.. .|::....|: :|.
Mouse   613 LC--------KIQGTSS---IHIILRDKMLSQIKMVKTSEINPYQNLE-AGIANILKPI-EDFCT 664

  Fly   573 -YYVLTDEGCIHKCSINYQHQYLE---------------VLRCHDGGVTVMEFSPWSPKLFLTCG 621
             ::|.|:||     .:.|....:|               :...|||.|..::.||:...:.||.|
Mouse   665 KFFVGTEEG-----EVIYTDWKMERDSDTGRLMAKKPVSLYTVHDGAVHTIQRSPFFNDIVLTVG 724

  Fly   622 NDWFVRIWVDGI-TRPLLELL---DEMTPVHWAKWSPTHSTIIVTVNRETANV--WDFRRNLLRP 680
            . |.|.||.:.: |.|||:..   ...|..||:...|.    :..:.||..||  ||.......|
Mouse   725 G-WNVAIWKEEVMTGPLLQTCCGPKRYTAGHWSLTRPG----VFYIGREDGNVDIWDLLEKTHEP 784

  Fly   681 MSKHKMDSSFNTVAR---FSHCGRTLVIGNERGNTLFNALNDMPFSPHFQYDELEKAIFKAIGND 742
            .....:..:..|..:   ||...:.:.:.:..| ||.  :.::|::                 ..
Mouse   785 AQSQNICITMITYIKPWTFSSKQQFIAVADYYG-TLH--ILEIPWT-----------------LS 829

  Fly   743 HELLMELKSIGFF 755
            |..|.|:.|:.::
Mouse   830 HPSLNEVSSVNYY 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	95/544 (17%)
		WD40 repeat	381..429	CDD:293791	12/54 (22%)
		WD40	433..711	CDD:295369	77/440 (18%)
		WD40 repeat	434..473	CDD:293791	11/72 (15%)
		WD40 repeat	552..599	CDD:293791	10/64 (16%)
		WD40 repeat	604..637	CDD:293791	11/33 (33%)
		WD40 repeat	645..682	CDD:293791	11/38 (29%)
		WD40 repeat	691..727	CDD:293791	7/38 (18%)
Dnai3	NP_766452.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		WD40	<384..>532	CDD:225201	21/149 (14%)
		WD 1. /evidence=ECO:0000255	398..438		8/39 (21%)
		WD 2. /evidence=ECO:0000255	480..536		4/55 (7%)
		WD 3. /evidence=ECO:0000255	702..741		15/39 (38%)
		WD 4. /evidence=ECO:0000255	745..785		10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810