DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dic61B and dyci-1

DIOPT Version :9

Sequence 1:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001370459.1	Gene:	dyci-1 / 177440	WormBaseID:	WBGene00015927	Length:	643	Species:	Caenorhabditis elegans

Alignment Length:	696	Identity:	133/696 - (19%)
Similarity:	255/696 - (36%)	Gaps:	191/696 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 QDDTYVEQFMKYNLNVMHQMTNFTTMVAKSTTRSRTRSSVRAGIGGNKQSIDDLMNGILYETINW 151
            ::|..|:..::        .||........|:| :|.||         ..::|::..:   .|:.
Worm    26 EEDARVQNLLR--------STNENGTTQNGTSR-QTLSS---------NEVEDILRQV---GIST 69

  Fly   152 EPYSTVEALEEAYEPKPYTKS---------------FLKITLRKSDFFEIHSQTQTT-------V 194
            ||  ||.  ||:..|.|.:.|               .|.:.|..|..     ||..|       .
Worm    70 EP--TVR--EESPAPPPGSHSDNHVDPSASHPRISNLLSVDLEFSSV-----QTACTDNKDSAIY 125

  Fly   195 AKGSPEGDDA------ERDNRNYEY-----LTIGKGKIRRRSDNDAQTDTLLFTTRAVNTILITK 248
            :||:...|:.      ...::.::|     :.:..|:.|.|:.:..|...|.:
Worm   126 SKGTQTDDERISVGEFSLGSQEFDYDDDMIMPMDHGQFRGRAHSHDQDSPLPY------------ 178

  Fly   249 ATVSSYVSNFEMYDTLNNITKEFATATMSSVKDLTSALAQTEDADTFEDDEAVAEKDKVSSQIER 313
                    |.|:...|..        |....|.||....:.:...|.:....:::::|.     |
Worm   179 --------NEEIAKLLGQ--------TKQGDKGLTRQETEEKKTQTVQIVPPLSDEEKY-----R 222

  Fly   314 LFRSPEFRNAIMYMGRTLSSNTNEAGLRRFRNF--DQVERWNAEAEYVYSMNLLFRLVPEPSKDE 376
            |...|||.::.....:.:|...||. :....|:  |..|:..|..:.::    |.::..:.:...
Worm   223 LTLDPEFLDSFNRSCKVISRALNEE-IDICINYTKDPYEKAIASDDLLH----LAQVYQDETWTA 282

  Fly   377 RKAVSDIDFCRSNGDILAVAYGLYSFSSQHVPTSGSVFLWSIKNPG-EPERAYYYDVPVTAINFS 440
            ::.|:.:.|.....|:|||:||.....::   ..|.:.:|:.|:.. ..|...|....:.::.|:
Worm   283 KRLVTGMAFSEHYPDLLAVSYGPCDIPNE---PPGVIVVWNTKSKRMTAEFIVYCQSEIQSVAFA 344

  Fly   441 PFLPSLLAIGLYDGSVEVRD--VSSLQDTPVAVSQRSTSPGSSPV--VAIRWIKQVSDDDHETDI 501
            .|...||..|...|.:.|.|  ::| :..|:..|..:|...:..|  :|:...|...:
Worm   345 RFHAHLLLAGCESGQICVWDNRLTS-RKLPINRSPLTTQAHTYTVSCLAVVGTKNAHN------- 401

  Fly   502 DPFLSLSQDGSVTRFRIIKSPFLLGFTQMILERVEGH----PEGIFVHPSSRIPCESNRHPQGLS 562
              |:|||:||.:..:.:          ..:.:.|:|.    .||                 :..|
Worm   402 --FVSLSRDGRICSWNV----------DNLTQPVDGKELMTKEG-----------------KAAS 437

  Fly   563 IT--THPL-HKDIYYVLTDEG------------CIHKCSINYQHQYLEVLRCHDGGVTVMEFSPW 612
            .|  :.|: ....:.|.||.|            .:.|..:.|        :.|.|.:|.:||...
Worm   438 ATRMSFPIGEMQTFVVGTDTGEILAASRNGADPAVIKTDVCY--------KGHSGTLTGIEFHRA 494

  Fly   613 S-----PKLFLTCGNDWFVRIWVDGITRPL-LELLDEMTP--VHWAKWSPTHSTIIVTVNRE-TA 668
            |     ..||::..:||.|::|   .|:.. |:...|..|  |....|||.|..:..:::.: ..
Worm   495 SGVVDFSHLFISSSHDWTVKLW---STKDANLKFSFESHPDLVLDVAWSPVHPAVFASIDADGNI 556

  Fly   669 NVWDFRRNLLRPMSKHKMDSSFNTVAR----FSHCGRTLVIGNERG 710
            .||:...::..|:::.:..:...:|..    :|..|:.:.:|::.|
Worm   557 FVWNLNEDVEGPVARLRAGAEGESVYMNRLIWSPDGKHVFVGDDEG 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	77/390 (20%)
		WD40 repeat	381..429	CDD:293791	11/48 (23%)
		WD40	433..711	CDD:295369	63/314 (20%)
		WD40 repeat	434..473	CDD:293791	10/40 (25%)
		WD40 repeat	552..599	CDD:293791	9/61 (15%)
		WD40 repeat	604..637	CDD:293791	11/37 (30%)
		WD40 repeat	645..682	CDD:293791	9/39 (23%)
		WD40 repeat	691..727	CDD:293791	5/24 (21%)
dyci-1	NP_001370459.1	WD40 repeat	286..333	CDD:293791	12/49 (24%)
		WD40 repeat	339..383	CDD:293791	12/44 (27%)
		WD40	382..>611	CDD:421866	51/268 (19%)
		WD40 repeat	388..457	CDD:293791	18/104 (17%)
		WD40 repeat	487..528	CDD:293791	12/43 (28%)
		WD40 repeat	534..573	CDD:293791	8/38 (21%)
		WD40 repeat	581..609	CDD:293791	5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810