DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dic61B and DNAI3

DIOPT Version :9

Sequence 1:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_660155.2	Gene:	DNAI3 / 126820	HGNCID:	30711	Length:	891	Species:	Homo sapiens

Alignment Length:	891	Identity:	150/891 - (16%)
Similarity:	283/891 - (31%)	Gaps:	322/891 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 DLQYRSQI-------KVLEKIYGEEVDMTPKSIQDDTYVEQFMKYNLNVMHQMTNFTTMVAKSTT 118
            ||:.|:.:       |::::..|.|:.:        .|.:.| ||.||..        ::|
Human    77 DLRNRAAVSDFHPVKKIVQEYPGNELLL--------VYDKDF-KYGLNFY--------LIA---- 120

  Fly   119 RSRTRSSVRAGIGGNKQSIDDLMNGILYETINWEPYSTVEALEE----------AYEPKPYTKSF 173
                          .::..::.:|          |....|..||          .|:| |.:|.:
Human   121 --------------TEEGKENYLN----------PPEVPEEQEEYKEHIPEDVYIYKP-PVSKPW 160

  Fly   174 LKITLRKSDFFEIHSQTQTTVAKGSPEGDDAERDNRNYEYLTIGKGKIRRRSDNDAQTDTLLFTT 238
            :.:...|.  .|..|.|::|               :...|:.     .|:||:..|   .:.|:.
Human   161 VSLGSEKE--IEEESVTEST---------------KQITYMI-----SRKRSEFGA---PIKFSD 200

  Fly   239 RAVNTILITKATVSSYV-SNFEMYDTLNNITKEFATATMSSVKDLTSALAQT------------- 289
            :..:::.......::|. .||    ||..:.|:.....:..:||:::....|
Human   201 QNASSVKDAYIECTAYPDKNF----TLKQLEKDVGMQVIPQIKDISTQTKWTYPKNATTQYYPRE 261

  Fly   290 ---EDADTFEDDEAVAE-KDKVSSQIERLFRSPEFRNAIM----YMGR---TLSSNTNEAGLRRF 343
               |:.:|.:..:.:.: .:..|..:|...:..|..|..:    |:..   |....| :..|:.:
Human   262 FSEEEKETLKQSKPLVDFLNNASISVEIALQQNEIMNTFIDDWKYLAEEEGTFGDKT-DTHLKEY 325

  Fly   344 RNFDQVERWNAEAEYVYSMNLLFRLVPEPSKDERKAVSDIDFCRSNGDILAVAYGLYSFSSQHVP 408
            ::|..:.                    .|::   |.::.:.:..:...::||:..:.......|.
Human   326 QSFTDLH--------------------SPTE---KMITCVSWHPTIYGLIAVSVAVRLSFEDRVH 367

  Fly   409 TSGSVFL-------WSIKNPGEPERAYYYDVPVTAINFSPFLPSLLAIGLYDGSVEVRDVSSLQD 466
            .||.:.|       ||..:|..|:........:....|.|..|:::|.|..:|.:.:.|:::..|
Human   368 FSGKLLLQPSLILFWSFSDPIHPQLMLESPDDIFCFKFCPSDPNIIAGGCINGQIVMWDITAHAD 432

  Fly   467 TPVAV------SQRST-------SPGSSP--------------------VVAIRWIK-------- 490
            ....:      |:|:|       .|.|:.                    :..|.|:.
Human   433 RIENIKAGGSRSKRATLKPMFLLEPESNKEAMYIRHCAVSSIENGHKKVITDIHWLSDTFEINRM 497

  Fly   491 ------------------------------------QVSDDDHETDID-PF--------LSLSQD 510
                                                |.::...|..|: ||        |.||..
Human   498 GSVFENRSGICCQLVTCSADCTICFWDIRPQKPLTPQTTEKKKEESIEIPFDVPSTFLHLDLSWK 562

  Fly   511 GSVTRFRIIKSPFLLGFTQMILERVEGHPEGIFVHPSSRIPCESNRHPQGLSIT-----THPLH- 569
             .:|:.|:.|....|......:...|.|           :.|::.......|.|     .:|.|
Human   563 -PLTKVRLSKGETSLDHCPTKISLNEDH-----------LLCKTQDKMLAQSKTEKAEEMNPYHN 615

  Fly   570 ---------KDI------YYVLTDEG-----------------CIHKCSINYQHQYLEVLRCHDG 602
                     |.|      ::|.|:||                 .:.|..:::.       ..|||
Human   616 LESGMANLLKPIDDFCTKFFVGTEEGEVIYTDWKMEKDPETGRLMSKKPVSHH-------TIHDG 673

  Fly   603 GVTVMEFSPWSPKLFLTCGNDWFVRIWVDGI-TRPLLELL---DEMTPVHWAKWSPTHSTIIVTV 663
            .|..::.||:...:.||.|. |.|.||.:|: |.|||:..   ...|..||:...|.    :..:
Human   674 TVHTIQRSPFYNDIILTVGG-WNVAIWKEGVMTGPLLQSCCAPKRYTSGHWSLTRPG----VFYI 733

  Fly   664 NRETA--NVWDFRRNLLRPMSKHKMDSSFNTVAR---FSHCGRTLVIGNERGN--------TLFN 715
            .||..  ::||.......|.....:..:..|..:   ||...:.:...:..|.        ||..
Human   734 GREDGYIDIWDLLEKTHEPAQSQNICITMITYIKPWIFSSKQQFIATADYYGTLHILEIPWTLSR 798

  Fly   716 -ALNDMPFSPHF--------QYDELEKAIFKAIGNDHELLMELKSI 752
             :.|:|....|:        :|.|..|.|.:....:.||.|..|.:
Human   799 PSTNEMASVNHYFEREVKHLEYVEQRKKIREQEKKEMELEMAKKKV 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	90/528 (17%)
		WD40 repeat	381..429	CDD:293791	10/54 (19%)
		WD40	433..711	CDD:295369	71/410 (17%)
		WD40 repeat	434..473	CDD:293791	8/44 (18%)
		WD40 repeat	552..599	CDD:293791	12/84 (14%)
		WD40 repeat	604..637	CDD:293791	12/33 (36%)
		WD40 repeat	645..682	CDD:293791	9/38 (24%)
		WD40 repeat	691..727	CDD:293791	9/55 (16%)
DNAI3	NP_660155.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		WD40	197..>531	CDD:225201	48/361 (13%)
		WD40	370..793	CDD:225201	78/446 (17%)
		WD 1. /evidence=ECO:0000255	395..435		8/39 (21%)
		WD 2. /evidence=ECO:0000255	477..533		2/55 (4%)
		WD 3. /evidence=ECO:0000255	670..709		16/39 (41%)
		WD 4. /evidence=ECO:0000255	713..753		8/43 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810