DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dic61B and Dync1i2

DIOPT Version :9

Sequence 1:NP_728477.1 Gene:Dic61B / 38020 FlyBaseID:FBgn0263988 Length:764 Species:Drosophila melanogaster
Sequence 2:NP_446332.2 Gene:Dync1i2 / 116659 RGDID:620174 Length:638 Species:Rattus norvegicus


Alignment Length:754 Identity:152/754 - (20%)
Similarity:264/754 - (35%) Gaps:231/754 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 SNLDNELKKKSVVVNQTQAE----ESKAKKKDTTH----YYSVETLADLQ-YRSQIKVLEKIYGE 77
            |.|..||::|...:.|.:.|    |.:.|||:|..    ..||:..:||: .|.:.:.|.:..|.
  Rat     5 SELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAAVSVQEESDLEKKRREAEALLQSMGL 69

  Fly    78 EVD-------------MTPKSIQDDTYVEQFMKYNLNVMHQMTNFTTMVAKSTTRSRTRSSVRAG 129
            ..|             |:|.|                             ||.:......|..:|
  Rat    70 TTDSPIVFSEHWVPPPMSPSS-----------------------------KSVSTPSEAGSQDSG 105

  Fly   130 IG--GNKQSIDDLMNGILYETINWEPYSTVEALEEAYE--PKPYTKSFLKITLRKSDF-----FE 185
            .|  |::             |::|:...:...|....:  ..|......|||  :.||     ..
  Rat   106 DGAVGSR-------------TLHWDTDPSALQLHSDSDLGRGPIKLGMAKIT--QVDFPPREIVT 155

  Fly   186 IHSQTQTTVAKGSPEGDDAERDNRNYEYLTIGKGK----------IRRRSDNDAQTDTLLFTTRA 240
            ...:|||.|. ..|:.|:.|.|:       :...|          :::..:||::...       
  Rat   156 YTKETQTPVT-AQPKEDEEEEDD-------VAAPKPPVEPEEEKILKKDEENDSKAPP------- 205

  Fly   241 VNTILITKATVSSYVSNFEMYDTLNNITKEFATATMSSVKDLTSALAQTEDADTFEDDEAVAEKD 305
                                    :.:|:|          :....|...|....|:....:.|: 
  Rat   206 ------------------------HELTEE----------EKQQILHSEEFLSFFDHSTRIVER- 235

  Fly   306 KVSSQIERLFRSPEFRNAIMYMGRTLSSNTNE--AGLRRFRN---FDQVERWNAEAEYVYSMNLL 365
            .:|.||...|.         |.||.|.....|  ||.:...|   ||  |||:            
  Rat   236 ALSEQINIFFD---------YSGRDLEDKEGEIQAGAKLSLNRQFFD--ERWS------------ 277

  Fly   366 FRLVPEPSKDERKAVSDIDFCRSNGDILAVAYGLYSFSSQHVPTSGSVFLWSIK-NPGEPERAYY 429
                      :.:.||.:|:.....::|..:|. .:..:.|.| .|...:|::| ....||..::
  Rat   278 ----------KHRVVSCLDWSSQYPELLVASYN-NNEEAPHEP-DGVALVWNMKYKKTTPEYVFH 330

  Fly   430 YDVPVTAINFSPFLPSLLAIGLYDGSVEVRDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQVSD 494
            ....|.:..|:.|.|:|:..|.|.|.:.:.|..|.:.|||..:..|.:..:.||..:..:.  :.
  Rat   331 CQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVG--TQ 393

  Fly   495 DDHETDIDPFLSLSQDGSVTRFRIIKSPFLLGFTQMILERVEGHPEGI--FVHPSSR-IPCESNR 556
            :.|.     .:|:|.||.:..:.:          .|:     .||:..  .||..|: :...|..
  Rat   394 NAHN-----LISISTDGKICSWSL----------DML-----SHPQDSMELVHKQSKAVAVTSMS 438

  Fly   557 HPQGLSITTHPLHKDI--YYVLTDEGCIH-KCSINYQHQYLEVLRCHDGGVT---------VMEF 609
            .|.|          |:  :.|.::||.:: .|....:....|:...|.|.:|         .::|
  Rat   439 FPVG----------DVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDF 493

  Fly   610 SPWSPKLFLTCGNDWFVRIWVDGITRPLLELLDEMTPVHWAKWSPTHSTIIVTVN-RETANVWDF 673
            |    .||:|...||.|::|.....:||....|....|:...|||||..:...|: ....::|:.
  Rat   494 S----HLFVTSSFDWTVKLWTTKNNKPLYSFEDNSDYVYDVMWSPTHPALFACVDGMGRLDLWNL 554

  Fly   674 RRNLLRPMSKHKMDS--SFNTVARFSHCGRTLVIGNERG 710
            ..:...|.:...::.  :.|.| |::|.||.:.:|:..|
  Rat   555 NNDTEVPTASISVEGNPALNRV-RWTHSGREIAVGDSEG 592

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dic61BNP_728477.1 WD40 358..730 CDD:225201 80/372 (22%)
WD40 repeat 381..429 CDD:293791 11/48 (23%)
WD40 433..711 CDD:295369 68/296 (23%)
WD40 repeat 434..473 CDD:293791 13/38 (34%)
WD40 repeat 552..599 CDD:293791 9/49 (18%)
WD40 repeat 604..637 CDD:293791 10/41 (24%)
WD40 repeat 645..682 CDD:293791 9/37 (24%)
WD40 repeat 691..727 CDD:293791 8/20 (40%)
Dync1i2NP_446332.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..135 32/171 (19%)
Interaction with DYNLT1. /evidence=ECO:0000269|PubMed:27502274 133..165 9/33 (27%)
Dynein_IC2 135..163 CDD:402922 8/29 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 154..209 11/93 (12%)
WD 1 277..326 10/72 (14%)
WD40 repeat 282..331 CDD:293791 12/50 (24%)
WD40 329..>599 CDD:225201 68/301 (23%)
WD 2 330..370 11/39 (28%)
WD40 repeat 339..377 CDD:293791 12/37 (32%)
WD 3 379..420 10/62 (16%)
WD40 repeat 385..426 CDD:293791 8/62 (13%)
WD 4 429..469 9/49 (18%)
WD40 repeat 434..481 CDD:293791 11/56 (20%)
WD 5 474..519 14/48 (29%)
WD40 repeat 489..521 CDD:293791 11/35 (31%)
WD40 repeat 527..565 CDD:293791 9/37 (24%)
WD 6 568..607 8/26 (31%)
WD40 repeat 573..599 CDD:293791 8/21 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1587
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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