DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dic61B and dnai4

DIOPT Version :9

Sequence 1:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001106504.1	Gene:	dnai4 / 100127694	XenbaseID:	XB-GENE-5890871	Length:	795	Species:	Xenopus tropicalis

Alignment Length:	833	Identity:	190/833 - (22%)
Similarity:	335/833 - (40%)	Gaps:	138/833 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSASVRNTVTSQENGSIFKRSSNLDNELKKKSVV---VNQTQAEES---------KAKKKDTTHY 53
            ||........:::..|:....|.|....||.||:   |.|::..:|         .::|....|.
Frog     1 MSGPTATEGKAKKLNSVVTMRSKLGAHFKKPSVISGSVTQSRMNQSIFNRSMLGTSSRKSLNLHA 65

  Fly    54 YSV--ETLADLQYRSQIKVLEKIYGEEVD-------------------MTPKSIQDDTYVEQFMK 97
            .|.  |....|..:..||:|:. .|::|.                   .||.........:.|..
Frog    66 ESKMGERNLSLVGKQNIKILDD-DGKDVSPQPLFQAEPGTVPQKQSKLFTPPDASGIATSDMFSS 129

  Fly    98 YNLNVMHQMTNFTTMVAKSTTRSRTRSSVRAGIGGNKQSIDDLMNGILYETINWEPYSTVEALEE 162
            .:|    |.|.|........|||....|..:......:|:.:.:....::.   |..|..|...:
Frog   130 LSL----QQTAFNASFVGPFTRSTFGGSTVSRSSKETESLTEYIEDTGFKR---ELASLSEIQGK 187

  Fly   163 AYEPKPYTKSFLKITLRKSDFFEIHSQT----QTTVAKGSPEGDDAERDN-RNYEYLTIGKGKIR 222
            .:|.:|..:...||.    :.|...::|    ....|..|.:.::|:... ||..|..:.|.|:
Frog   188 QHEMQPIEEDLDKII----NIFITDTETLWLLDMPPALTSSDSENADLIRVRNQAYEDLCKDKV- 247

  Fly   223 RRSDNDAQTDTLLFT------TRAVNTILITKATVSSYVSNFEMYD------------TLNNIT- 268
               .||...:.::.|      ::.|....|....:....|.:::||            |::..|
Frog   248 ---GNDKYIERMMQTFSGAPKSKEVQCDRIILEDIGVTASVWDLYDSYYSPESLTVKETVDRATE 309

  Fly   269 -KEFATATMSSVKDLTSALAQTEDADTFEDDEAVAE-------KDKVSSQIERLFRSPEFRNAIM 325
             |..:|:..|..:. |.::.....||:|.......|       .|:.....|.:.:..:|:..:.
Frog   310 SKNISTSRSSESRG-TRSVNSLGRADSFSSSATDIEGLPLARIPDEAEPDSEEILKLEKFQQDLF 373

  Fly   326 YMGRTLSSNTNEAGLRRFRNFDQVERWNAEAEYVY---------SMNLLFRLVPEPSKDERKAVS 381
            :|.|.:..||.::.|..:|....:.....:.:.:.         |:|.|:....:.:|...  ||
Frog   374 FMERVVVENTFQSRLAAYRQLPVIADHEEDEDKISAVSSNIMSPSLNRLWSFACDVTKGHN--VS 436

  Fly   382 DIDFCRSNGDILAVAYGLYSFSSQHVPTSGSVFLWSIKNPGEPERAYYYDVPVTAINFSPFLPSL 446
            .|.:.:.|.|:|||.||.:.|:.|   ..|....||:||...|||.::.:..|||::||...|:|
Frog   437 SISWNKKNSDLLAVGYGQFGFTEQ---KGGMACCWSLKNIMWPERIFHCECGVTAVDFSAVHPNL 498

  Fly   447 LAIGLYDGSVEVRDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIK----QVSDDDHETDIDPFLSL 507
            ||:|:|:|:|.:.:|.:.:|.||..|..:.:..:|||..::||:    .:.||..|.    .:|:
Frog   499 LAVGMYNGTVAIYNVQNNEDFPVLDSSDNPNKHTSPVWQLKWIEHDRGNLGDDKGEI----LVSV 559

  Fly   508 SQDGSVTRFRIIKSPFLLGFTQMILERVEGHPEGIFVHPSSRIPCESN-----------RHPQGL 561
            ..||.:||:.|.|.   |....::..:..|         |.:....||           |...|:
Frog   560 CADGRITRWHIRKG---LDCNDLMKLKRTG---------SEKSKKSSNEKEKKGEAFISRQAPGM 612

  Fly   562 SITTHPLHKDIYYVLTDEGCIHKCSINYQHQYLEVLRCHDGGVTVMEFSPWSPKLFLTCGNDWFV 626
            .....|...:||...|:||.|||||.:|..|:|:..|.|.|.|..:.:||:.|.:||:|..||.:
Frog   613 CFDFLPKDSNIYLAGTEEGHIHKCSCSYNEQFLDTYRGHKGPVYKIAWSPFCPDVFLSCSADWCI 677

  Fly   627 RIWVDGITRPLLELLDEMTPVHWAKWSPTHSTIIVTVNRETANVWDFRRNLLRPMSKHKMDSSFN 691
            .:|...:..|:|...:....|:...|||:.:.:...|......:||...:.:.|:..::.:....
Frog   678 HLWQQDVLSPILTFSNTTNAVYDIMWSPSSALMFGAVTENRVEIWDLGTSTIDPLIVNEANPGVK 742

  Fly   692 TV----ARFSHCGRTLVIGNERGNTLFNALNDMPFSPHFQYDELEKAIFKAIG 740
            ..    |:.::|   ::||:..|......|.::..|.    |....|::..||
Frog   743 LTSILFAKNTNC---VLIGDSDGQVNVYELRNVSSSK----DSEVNALYDIIG 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	108/399 (27%)
		WD40 repeat	381..429	CDD:293791	19/47 (40%)
		WD40	433..711	CDD:295369	81/296 (27%)
		WD40 repeat	434..473	CDD:293791	17/38 (45%)
		WD40 repeat	552..599	CDD:293791	18/57 (32%)
		WD40 repeat	604..637	CDD:293791	10/32 (31%)
		WD40 repeat	645..682	CDD:293791	8/36 (22%)
		WD40 repeat	691..727	CDD:293791	7/39 (18%)
dnai4	NP_001106504.1	WD40	359..782	CDD:225201	117/450 (26%)
		WD40	431..768	CDD:295369	103/360 (29%)
		WD40 repeat	435..480	CDD:293791	20/47 (43%)
		WD40 repeat	487..523	CDD:293791	16/35 (46%)
		WD40 repeat	613..650	CDD:293791	14/36 (39%)
		WD40 repeat	656..693	CDD:293791	11/36 (31%)
		WD40 repeat	698..736	CDD:293791	8/37 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6433
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11702
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310818at33208
OrthoFinder	1	1.000	-	-		FOG0006125
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5769
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950