Protein Alignment CG6845 and DCST1

DIOPT Version :10

• Sequence 1: NP_612000.3
• Gene: CG6845 / 38019
• FlyBaseID: FBgn0035099
• Length: 672
• Species: Drosophila melanogaster
• Sequence 2: NP_689707.2
• Gene: DCST1 / 149095
• HGNCID: 26539
• Length: 706
• Species: Homo sapiens
• Alignment Length: 730
• Identity: 164/730 - (22%)
• Similarity: 276/730 - (37%)
• Gaps: 156/730 - (21%)

  Fly    28 GLAVTLAWNWWQL----------------GHLVLGLNLTFAIPVALV----LAVFYS-------- 64
            ||.|:.:|..|:.                |.|.:||......|:.:.    :...||
Human    29 GLPVSCSWFLWRQPGEFPVTALLLGAGAGGLLAIGLFQLLVNPMNIYEEQKIMFLYSLVGLGAMG 93

  Fly    65 ---RP-VRCIVTLALPSLCSSRGRAFLISLAFVIAAVGPTANILANLKVMLRSLACGQELLRQAL 125
               .| :||...|.:|.:....||.|::..|.....|||.||:..||..::.||.|..||.....
Human    94 WGTSPHIRCASLLLVPKMLGKEGRLFVLGYALAAIYVGPVANLRHNLNNVIASLGCTVELQINNT 158

  Fly   126 GQMLDVILEPVNA----IQLAVDLLMREVR---------------------------------RV 153
            .....:...|:.|    :..:.:||..|.|                                 |.
Human   159 RAAWRISTAPLRAMFKDLLSSKELLRAETRNISATFEDLDAQVNSETGYTPEDTMDSGETAQGRE 223

  Fly   154 LKLAMVVLLRIQDQLIAIIKTLKNCAAWLKSIVDLCNTEMGTPWARCKKTAHHAMIRCQSKMGVF 218
            .:.|....|.:..|.:..:||...|:..:...:..|.........:|.|   |..:...:.:
Human   224 ARQAPASRLHLSTQKMYELKTKLRCSYVVNQAILSCRRWFDRKHEQCMK---HIWVPLLTHL--- 282

  Fly   219 KALCHAAKLFLALCYPAKIIDVFCSGYWDLSWGLLDKIAERYREFVRHIEEMFDANITFEHE--- 280
              ||...| |...|..||:::|:|.....:. |...:..:...:.:|.::..|.|||.|:.|
Human   283 --LCLPMK-FKFFCGIAKVMEVWCRNRIPVE-GNFGQTYDSLNQSIRGLDGEFSANIDFKEEKQA 343

  Fly   281 --FFFDTNSSKSLTDVGEEILQDINKRLSSFIFLSSFVDILCWVMVVTVFFKATIFYL-RYMHSR 342
              ...:|:..:..|:|.:.:.:. ..||...:.| ..|.:.|..::|   ..|:..|: .|.|..
Human   344 GVLGLNTSWERVSTEVRDYVYRQ-EARLEWALGL-LHVLLSCTFLLV---LHASFSYMDSYNHDI 403

  Fly   343 QFQNVFLTKILSDIDRRHEKHGYDPLLPLHQLERAKYMKLTSLRLTLFEFVSIVENACFMATTCL 407
            :|.|::::.....||.|.:|.|...||||.:.|....:......:...|..::|..........|
Human   404 RFDNIYISTYFCQIDDRRKKLGKRTLLPLRKAEEKTVIFPCKPTIQASEMSNVVRELLETLPILL 468

  Fly   408 QLFAICFLDYGLFWLLATISLHGHQETGLEVPAYVDLEIKGGGFVADVMRGIANAFRPLTQKSIL 472
            .|..:|.||:.|:.:..||..|...:........:::::.|...:|.::|....|.. .:.::::
Human   469 LLVVLCGLDWALYSIFDTIRHHSFLQYSFRSSHKLEVKVGGDSMLARLLRKTIGALN-TSSETVM 532

  Fly   473 DVN--PCLPLPVKPDYAEYL-----IILLLCLLAWLILLAEPYILRTRHLIMAHFYPKRAKERGM 530
            :.|  ||||.||..|...|.     |.||:||     .|.:.:..|.|.:|.|.::|||.|:|.:
Human   533 ESNNMPCLPQPVGLDARAYWRAAVPIGLLVCL-----CLLQAFGYRLRRVIAAFYFPKREKKRIL 592

  Fly   531 FLYNMISEDRTSIFKF----IRRRKRNEFNHTRNVKHTRN-------------YTWLNNRFSCLM 578
            ||||.:.:.|.:..|.    |.||:|.:       |..|:             ..||
Human   593 FLYNDLLKKRAAFTKLRRAAILRRERQQ-------KAPRHPLADILHRGCPLLRRWL-------- 642

  Fly   579 CMCSCCSSCQSTERCTICGRSLTLSNRNP----CDTPGCKGVYCGKCFEKSHNKCCLCNRPVDYG 639
              |..|..||:.|              .|    |.|..|:.|||..|::....:|.:|. |.:..
Human   643 --CRRCVVCQAPE--------------TPESYVCRTLDCEAVYCWSCWDDMRQRCPVCT-PREEL 690

  Fly   640 DFSDVTEVDDSSDYS 654
            ..|..::.:|.:.|:
Human   691 SSSAFSDSNDDTAYA 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6845	NP_612000.3	DC_STAMP	344..533	CDD:462265	52/195 (27%)
DCST1	NP_689707.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..230		2/25 (8%)
		DC_STAMP	405..595	CDD:462265	52/195 (27%)