DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pdk1 and RPS6KA5

DIOPT Version :10

Sequence 1:NP_728471.2 Gene:Pdk1 / 38017 FlyBaseID:FBgn0020386 Length:836 Species:Drosophila melanogaster
Sequence 2:NP_004746.2 Gene:RPS6KA5 / 9252 HGNCID:10434 Length:802 Species:Homo sapiens


Alignment Length:621 Identity:142/621 - (22%)
Similarity:242/621 - (38%) Gaps:176/621 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 EQQQQQEQSQQQQQLQNPAPRRSPNDFIFGRYIGEGSYSIVYLAVDIHSR---REYAIKVCEKRL 281
            ||....:...:...|...|.:....:|...:.:|.|:|..|:|...|...   :.||:||.:|..
Human    23 EQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKAT 87

  Fly   282 ILRERK-QDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVA 345
            |:::.| .::.:.||:|:..:...|..|.|...||.:..|:.::.|...|::..::::...|   
Human    88 IVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERF--- 149

  Fly   346 CTRH----YAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEH 406
             |.|    |..|::||.||:|:..:::||:|.||||||.:.|.::.|||.:|...|.|    || 
Human   150 -TEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADE----TE- 208

  Fly   407 CSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFV 471
                                                                       |..||.
Human   209 -----------------------------------------------------------RAYSFC 214

  Fly   472 GTAQYVSPEVLQNGPI--TPAADLWALGCIVYQMIAGLPPF----RGSNDYVIFKEILDCAVDFP 530
            ||.:|::|::::.|..  ..|.|.|:||.::|:::.|..||    ..::...|.:.||.....:|
Human   215 GTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYP 279

  Fly   531 QGFDKDAEDLVRKLLRVDPRDRLGA--QDEFGYYESIRAHPFFAGIDWQTL-RQQTPPPIYPYLP 592
            |.....|:||:::||..||:.|||.  :|.    :.|:.|.||..|:|..| .::.|.|..|.:.
Human   280 QEMSALAKDLIQRLLMKDPKKRLGCGPRDA----DEIKEHLFFQKINWDDLAAKKVPAPFKPVIR 340

  Fly   593 GVSQDEDFRSSYTVPGDLEPGLDERQISRLLSAELGVGSSVAMP---VKRSTA------------ 642
            ......:|...:|   :::|......:.: .|.:|..|.|...|   .||:.|            
Human   341 DELDVSNFAEEFT---EMDPTYSPAALPQ-SSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVE 401

  Fly   643 -------KNSFDLNDAEKLQRLEQQKTDKWHVFADGEVILKKGFVNKRKG-LFA----RKRM--- 692
                   ..|..:.|:...|..:....||  ...:|...:.:..|:|:.. .||    .|||   
Human   402 RPGVTNVARSAMMKDSPFYQHYDLDLKDK--PLGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN 464

  Fly   693 -------LLLTTG-PRLIYIDPV-----------QMIKKGEIPWSPDLRAEYKNFKIFFVHTPNR 738
                   |.|..| |.::.:..|           :::..||:                |.....:
Human   465 TQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGEL----------------FERIKKK 513

  Fly   739 TYYLDDPEGYAIHWSEAIENMRKLAYGDPSSTSAVS 774
            .::.:         :||...||||       .||||
Human   514 KHFSE---------TEASYIMRKL-------VSAVS 533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pdk1NP_728471.2 STKc_PDK1 244..571 CDD:270733 88/342 (26%)
PH_PDK1 658..764 CDD:241293 24/132 (18%)
RPS6KA5NP_004746.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23 142/621 (23%)
STKc_MSK1_N 48..337 CDD:270764 95/360 (26%)
S_TK_X 320..379 CDD:214529 13/62 (21%)
STKc_MSK1_C 418..727 CDD:271081 29/150 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 741..802
Blue background indicates that the domain is not in the aligned region.

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