Protein Alignment Pdk1 and PKH1

DIOPT Version :10

• Sequence 1: NP_728471.2
• Gene: Pdk1 / 38017
• FlyBaseID: FBgn0020386
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_010778.3
• Gene: PKH1 / 852101
• SGDID: S000002898
• Length: 766
• Species: Saccharomyces cerevisiae
• Alignment Length: 522
• Identity: 156/522 - (29%)
• Similarity: 240/522 - (45%)
• Gaps: 127/522 - (24%)

  Fly   201 QHQQGYQSQQQQQQPQQQQEQQQQQEQSQQQ--QQLQNPAP--------RRSPNDFIFGRYIGEG 255
            ||:.|.       .|..::.:::..|:...:  :.:.:||.        :....||.||..:|:|
Yeast    77 QHEMGL-------DPSMRRRREEWAERGAAKIVKDVVDPATGELTKHVVKMGIKDFKFGEQLGDG 134

  Fly   256 SYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSL 320
            |||.|.||....|.::||:||..|..::|::|..|:..|:..:.::....|...|..||||:.||
Yeast   135 SYSSVVLATARDSGKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKLNGTKGIFKLFFTFQDEASL 199

  Fly   321 YFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTL 385
            ||::.||..||.|..|.:.||.:..|.|:||::::.|.:.:|...::|||:||||||||::|...
Yeast   200 YFLLEYAPHGDFLGLIKKYGSLNETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDKNMKVK 264

  Fly   386 IADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDE-DFYDRDSEELDDGDDEQQQ 449
            :.|||:||::                      .:|.|:..:.:.. |.|.:..
Yeast   265 LTDFGTAKIL----------------------PEEPSNTADGKPYFDLYAKSK------------ 295

  Fly   450 EEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFRGSN 514
                               ||||||:|||||:|.:.......|:||.|||:|||:||.|||:.:|
Yeast   296 -------------------SFVGTAEYVSPELLNDNYTDSRCDIWAFGCILYQMLAGKPPFKAAN 341

  Fly   515 DYVIFKEILDCAVDFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQ-- 577
            :|:.|::::.....|..||.:..:|||:|||..||.|||       ..:.|:||.||..::::
Yeast   342 EYLTFQKVMKIQYAFTAGFPQIVKDLVKKLLVRDPNDRL-------TIKQIKAHLFFHEVNFEDG 399

  Fly   578 TLRQQTPPPIYPY---------LPGVSQDEDFRSSYTVP---------GDLEPGLDERQISRLLS 624
            ::....||.|.||         |..||:     |..||.         |..:..|   |.....|
Yeast   400 SVWDDNPPEIQPYKINAEAMKPLQKVSE-----SDTTVKMANLQLAGNGHADTPL---QAPAATS 456

  Fly   625 AELGVGSSVAMPVKRSTAKNSFDLNDAEKL-------QRLEQQKTDKWHVFADGEVILKKGFVNK 682
            .|..|.|..|     :||..:.|.....||       .|.....||:       |||.||  |:|
Yeast   457 QEHSVISMTA-----ATAAFNKDYTSQPKLGSKSSTSVRSASNNTDR-------EVIQKK--VSK 507

  Fly   683 RK 684
            .:
Yeast   508 NR 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdk1	NP_728471.2	STKc_PDK1	244..571	CDD:270733	113/327 (35%)
		PH_PDK1	658..764	CDD:241293	9/27 (33%)
PKH1	NP_010778.3	STKc_PDK1	123..391	CDD:270733	113/327 (35%)