DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdk1 and PKH1

DIOPT Version :9

Sequence 1:	NP_001261183.1	Gene:	Pdk1 / 38017	FlyBaseID:	FBgn0020386	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_010778.3	Gene:	PKH1 / 852101	SGDID:	S000002898	Length:	766	Species:	Saccharomyces cerevisiae

Alignment Length:	522	Identity:	156/522 - (29%)
Similarity:	240/522 - (45%)	Gaps:	127/522 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 QHQQGYQSQQQQQQPQQQQEQQQQQEQSQQQ--QQLQNPAP--------RRSPNDFIFGRYIGEG 255
            ||:.|.       .|..::.:::..|:...:  :.:.:||.        :....||.||..:|:|
Yeast    77 QHEMGL-------DPSMRRRREEWAERGAAKIVKDVVDPATGELTKHVVKMGIKDFKFGEQLGDG 134

  Fly   256 SYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSL 320
            |||.|.||....|.::||:||..|..::|::|..|:..|:..:.::....|...|..||||:.||
Yeast   135 SYSSVVLATARDSGKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKLNGTKGIFKLFFTFQDEASL 199

  Fly   321 YFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTL 385
            ||::.||..||.|..|.:.||.:..|.|:||::::.|.:.:|...::|||:||||||||::|...
Yeast   200 YFLLEYAPHGDFLGLIKKYGSLNETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDKNMKVK 264

  Fly   386 IADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDE-DFYDRDSEELDDGDDEQQQ 449
            :.|||:||::                      .:|.|:..:.:.. |.|.:..
Yeast   265 LTDFGTAKIL----------------------PEEPSNTADGKPYFDLYAKSK------------ 295

  Fly   450 EEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFRGSN 514
                               ||||||:|||||:|.:.......|:||.|||:|||:||.|||:.:|
Yeast   296 -------------------SFVGTAEYVSPELLNDNYTDSRCDIWAFGCILYQMLAGKPPFKAAN 341

  Fly   515 DYVIFKEILDCAVDFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQ-- 577
            :|:.|::::.....|..||.:..:|||:|||..||.|||       ..:.|:||.||..::::
Yeast   342 EYLTFQKVMKIQYAFTAGFPQIVKDLVKKLLVRDPNDRL-------TIKQIKAHLFFHEVNFEDG 399

  Fly   578 TLRQQTPPPIYPY---------LPGVSQDEDFRSSYTVP---------GDLEPGLDERQISRLLS 624
            ::....||.|.||         |..||:     |..||.         |..:..|   |.....|
Yeast   400 SVWDDNPPEIQPYKINAEAMKPLQKVSE-----SDTTVKMANLQLAGNGHADTPL---QAPAATS 456

  Fly   625 AELGVGSSVAMPVKRSTAKNSFDLNDAEKL-------QRLEQQKTDKWHVFADGEVILKKGFVNK 682
            .|..|.|..|     :||..:.|.....||       .|.....||:       |||.||  |:|
Yeast   457 QEHSVISMTA-----ATAAFNKDYTSQPKLGSKSSTSVRSASNNTDR-------EVIQKK--VSK 507

  Fly   683 RK 684
            .:
Yeast   508 NR 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdk1	NP_001261183.1	STKc_PDK1	244..571	CDD:270733	113/327 (35%)
		S_TKc	246..571	CDD:214567	112/325 (34%)
		PH_PDK1	658..764	CDD:241293	9/27 (33%)
PKH1	NP_010778.3	STKc_PDK1	123..391	CDD:270733	113/327 (35%)
PKH1	NP_010778.3	S_TKc	125..391	CDD:214567	112/325 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341970
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0592
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001781
OrthoInspector	1	1.000	-	-		otm46710
orthoMCL	1	0.900	-	-		OOG6_101713
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2717
SonicParanoid	1	1.000	-	-		X1315
TreeFam	1	0.960	-	-
	10	9.730