Protein Alignment Pdk1 and PKH3

DIOPT Version :9

• Sequence 1: NP_001261183.1
• Gene: Pdk1 / 38017
• FlyBaseID: FBgn0020386
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_010754.1
• Gene: PKH3 / 852077
• SGDID: S000002874
• Length: 898
• Species: Saccharomyces cerevisiae
• Alignment Length: 836
• Identity: 196/836 - (23%)
• Similarity: 314/836 - (37%)
• Gaps: 321/836 - (38%)

  Fly   240 RRSPNDFIFGRYIGEGSYSIVYLAVDIHS-RREYAIKVCEKRLILRERKQDYIKREREVMHQMT- 302
            :|||:||||...:|.||||.|:.|:|..| .:.||||||.|:.|::|.|..|:..|:..|:.:.
Yeast     5 KRSPHDFIFKEELGHGSYSTVFKALDKKSPNKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQ 69

  Fly   303 -NVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNV 366
             :..|.:.|..||.|:.:||||:.:|..|::|..::::|:|:...|||:.|:|:.|.|.:|...:
Yeast    70 KHHAGIIKLYYTFHDEENLYFVLDFAPGGELLSLLHKMGTFNDIWTRHFTAQLIDALEFIHSHGI 134

  Fly   367 VHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDED 431
            :||||||||:|||.|...:|.|||:|..:   :.:|:.:.......||..:|:::.
Yeast   135 IHRDLKPENVLLDRDGRLMITDFGAAATI---DPSLSGDSAKFNSDSNGSKDNQNC--------- 187

  Fly   432 FYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWAL 496
                                                |||||||:|||||:|........:|:|||
Yeast   188 ------------------------------------ASFVGTAEYVSPELLLYNQCGYGSDIWAL 216

  Fly   497 GCIVYQMIAGLPPFRGSNDYVIFKEILDCAVDFPQGFDKDAE-----------DLVRKLLRVDPR 550
            ||::||.:.|.|||||.|:...|::|:  |:|:|.|.:....           :||:|:|.::..
Yeast   217 GCMIYQFVQGQPPFRGENELKTFEKIV--ALDYPWGPNNRINNSTSPINPLVINLVQKILVIEVN 279

  Fly   551 DRLGAQDEFGYYESIRAHPFFAGIDW---------------QTLRQQT------PPPIYPYLP-- 592
            :|:.       .|.|:.||:|:.:||               |:|:|.|      |..|.|...
Yeast   280 ERIS-------LEQIKRHPYFSKVDWNDKIKIWRGIWQSQGQSLQQTTLGLPNIPQNILPTRQLH 337

  Fly   593 ------------------------------------GVSQDED-------FRSSYTVPGD----- 609
                                                |:|..:|       ...:.|.|.|
Yeast   338 VIDTPARSIQITKQKRKKPTKISNTTSSIVVWRKRLGISTGKDDLGTVPSTTPAVTAPNDTNVLT 402

  Fly   610 -----------LEPGLDERQISRLLSAELGVGSSV-----------------------------A 634
                       |.|.....|:.|   |:|...:.:                             :
Yeast   403 NTAAHSTANIALPPNSQSNQVKR---AQLVAPNRIPPKVPVINDNVRNKSIPRTKPNVPPLQTSS 464

  Fly   635 MPVKRSTAKNSFDLNDAEKLQRLEQQKTDKWHVFADGE-----VILKKGFV-------------- 680
            :|.|.||:..|    .|......|.:..|..|.. ||.     .:||:.:|
Yeast   465 IPQKLSTSSAS----SALSAPSTEIRNQDLTHTL-DGRNSIDIHVLKQDYVFIYGIPYEHEGPAM 524

  Fly   681 -----NK-----RKGLFARKR-----------MLLLTTGPRLIYIDPV----------------- 707
                 ||     ...|.|:.:           :|.|.....|.|.:.|
Yeast   525 SLNSYNKIDNDLITSLVAQHKEELKNSESFLQVLTLKKSGMLSYKNTVMEGNDDQENKEHQMANI 589

  Fly   708 -------------QMIKKGEIPWSPDLRAEYKNFKIFFVHTPN------------RTYYLDDPEG 747
                         ::.:||.:     :..:||| :|:|:..|:            ::..:::.|
Yeast   590 EDTDLSMYDFEFNELTRKGFL-----ILEKYKN-RIWFISLPSYSTLSKIPFNAVKSSTINNNE- 647

  Fly   748 YAIHWSEAIENMRKL------------------AYGDPSSTSAVS-----CSSGSSNSLAVIS-N 788
               :|.:.....|:|                  |..:|||...:|     .|.|  |::..:| .
Yeast   648 ---NWVDCFFRARQLLEEKQILDKISNVSFDSKASSEPSSPPPISRKERPLSIG--NNVTTLSYT 707

  Fly   789 SSAASSSNSP---TVKRSSPVNAPQA--------STASDN--RTLGSTRTGTSPSK 831
            :...|.:|:|   .|....|...|.:        ||.|..  |.|.|...|.:|.|
Yeast   708 AKNGSQNNAPQNDNVGEEKPFRIPSSTKDRPGANSTPSSRHPRVLSSNNAGETPKK 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdk1	NP_001261183.1	STKc_PDK1	244..571	CDD:270733	112/340 (33%)
		S_TKc	246..571	CDD:214567	111/338 (33%)
		PH_PDK1	658..764	CDD:241293	29/205 (14%)
PKH3	NP_010754.1	STKc_PDK1	9..293	CDD:270733	112/340 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0592
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46710
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2717
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.900