Protein Alignment Pdk1 and CDC15

DIOPT Version :9

• Sequence 1: NP_001261183.1
• Gene: Pdk1 / 38017
• FlyBaseID: FBgn0020386
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_009411.2
• Gene: CDC15 / 851274
• SGDID: S000000072
• Length: 974
• Species: Saccharomyces cerevisiae
• Alignment Length: 684
• Identity: 139/684 - (20%)
• Similarity: 240/684 - (35%)
• Gaps: 216/684 - (31%)

  Fly   252 IGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDY--IKREREVM-----HQMTNVPGFVN 309
            ||.|||.:||.|::.|:.:..|||.     ::.|..::.  |..|..::     :.:....||:.
Yeast    31 IGRGSYGVVYKAINKHTDQVVAIKE-----VVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIR 90

  Fly   310 LSCTFQDQRSLYFVMTYARKGDMLPYINRVGS-FDVACTRHYAAELLLACEHMHRRNVVHRDLKP 373
            .|      ..||.::.|...|.:...|:|..: .....::.|..:.||..:::|...|:|||:|.
Yeast    91 KS------YELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKA 149

  Fly   374 ENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSE 438
            .||||..|....:||||.:.::.:....||
Yeast   150 ANILLSADNTVKLADFGVSTIVNSSALTLA----------------------------------- 179

  Fly   439 ELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQM 503
                                             ||..:::||:|.|...:..:|:|:||..|.:|
Yeast   180 ---------------------------------GTLNWMAPEILGNRGASTLSDIWSLGATVVEM 211

  Fly   504 IAGLPPFRGSNDYVIFKEILDCAVDFPQGFDKDAED-----LVRKLLRVDPRDRLGAQDEFGYYE 563
            :...||:....|..|:..:.:.....|..|.:..:|     .|:.:.:....|:|.........|
Yeast   212 LTKNPPYHNLTDANIYYAVENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWINSTE 276

  Fly   564 SIRAHPF------FAGID--WQTLRQQTPPPIYPYLPGVSQDEDFRSSYTVPG------------ 608
            :::....      |...|  |....|:....|.|            |.:::..
Yeast   277 NVKVDKLNKFKEDFTDADYHWDADFQEEKLNISP------------SKFSLAAAPAAWAENNQEL 329

  Fly   609 DLEPGLDERQISRLLSAELGVGSSVAMPVKRSTAKNSFDL----------NDAEK-LQRLEQQKT 662
            ||.|..:.:.:|:|                :|::|...||          |.|:. ::.|.:...
Yeast   330 DLMPPTESQLLSQL----------------KSSSKPLTDLHVLFSVCSLENIADTIIECLSRTTV 378

  Fly   663 DKWHVFADGEVILKKGFVNKRKGLFARKRMLLLTTG--PRLIYID----------PVQMIKKGEI 715
            ||..:.|.|.:     ||...:...:|.|:..:..|  |.:|..:          |..:|:.| |
Yeast   379 DKRLITAFGSI-----FVYDTQHNHSRLRLKFIAMGGIPLIIKFEHLAKEFVIDYPQTLIECG-I 437

  Fly   716 PWSP-------------------DLRAE-------YKNFKIFF----VHTPNRTYYLDDPEGYAI 750
            .:.|                   ||.:.       :|:..|..    :|.......|.....||
Yeast   438 MYPPNFASLKTPKYILELVYRFYDLTSTAFWCRWCFKHLDISLLLNNIHERRAQSILLKLSSYA- 501

  Fly   751 HWS-EAI------ENMRKLAYGDPSSTSAVSCSSG---SSNS----LAVISNSSAASSSNSPTVK 801
            .|| |.|      ..::|.....|..|..|..|..   ::|.    .:.|.:||:...|:|||
Yeast   502 PWSFEKILPSLIDSKLKKKILISPQITYVVFKSINYMITTNDDKIHKSAIPSSSSLPLSSSPT-- 564

  Fly   802 RSSPVNAPQASTASDNRTLGSTRTGTSPSKKTAS 835
            |:||||:.|:.:.|...:|.:||..:....|:.|
Yeast   565 RNSPVNSVQSPSRSPVHSLMATRPSSPMRHKSIS 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdk1	NP_001261183.1	STKc_PDK1	244..571	CDD:270733	67/337 (20%)
		S_TKc	246..571	CDD:214567	67/337 (20%)
		PH_PDK1	658..764	CDD:241293	29/154 (19%)
CDC15	NP_009411.2	PKc_like	24..272	CDD:419665	66/319 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I1205
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050