Protein Alignment Pdk1 and pdpk1a

DIOPT Version :9

• Sequence 1: NP_001261183.1
• Gene: Pdk1 / 38017
• FlyBaseID: FBgn0020386
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_001070812.1
• Gene: pdpk1a / 768202
• ZFINID: ZDB-GENE-061013-109
• Length: 536
• Species: Danio rerio
• Alignment Length: 573
• Identity: 230/573 - (40%)
• Similarity: 326/573 - (56%)
• Gaps: 103/573 - (17%)

  Fly   207 QSQQQQQQPQQQQEQQQQQEQSQQQQQLQNPA--PRRS--PNDFIFGRYIGEGSYSIVYLAVDIH 267
            ::|...:.||....:.:..|.|       .||  |.:|  ..||.||:.:||||:|.|.||.::.
Zfish    41 RTQLNSRLPQHLGMEVRGGESS-------TPALKPPQSFKKEDFSFGKILGEGSFSTVVLAKELA 98

  Fly   268 SRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDM 332
            :.:|||:|:.||..|.:|.|..|:.||::::..:.: |.||.|..||||.:.|||.::||:.|::
Zfish    99 TGKEYAMKILEKNHIRKENKAHYVIREKDILSCIDH-PFFVKLFFTFQDSQKLYFALSYAKNGEL 162

  Fly   333 LPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTA 397
            |.||.::||||..|||.|.||::.|.|::|...::|||||||||||.||||..|.|||:||.:::
Zfish   163 LRYIRKIGSFDETCTRFYTAEIVCALEYLHTVGIIHRDLKPENILLCEDMHIQITDFGTAKQLSS 227

  Fly   398 HERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRY 462
            .         |.|.|:|
Zfish   228 D---------SAQTRAN------------------------------------------------ 235

  Fly   463 NRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFRGSNDYVIFKEILDCAV 527
                  ||||||||||||:|.......::||||:|||:||::|||||||..|:|:||::|:....
Zfish   236 ------SFVGTAQYVSPELLTEKSACKSSDLWAMGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEY 294

  Fly   528 DFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYPYLP 592
            :||:.|...|:|||::||.:|||.|||. :|.|.:..::.|.||..:.|:.|..||||.:.||||
Zfish   295 EFPEKFFPKAKDLVQRLLSLDPRKRLGC-EEMGGFGPLKGHMFFETVSWENLPLQTPPKLTPYLP 358

  Fly   593 GVSQ-DEDFRSSYTVPGDLEPGLDERQISRLLSAELGVGSSVAMPVKRSTA----------KNSF 646
            .::: |||:..:|           |..:|:..|.::...||..:...|..:          .|||
Zfish   359 AMAEDDEDYYGNY-----------EDLLSQFSSLQVVPSSSAQIVPPRPCSNIEQYIHDLDSNSF 412

  Fly   647 DLN---DAEKLQRLEQQKT--DKWHVFADGEVILKKGFVNKRKGLFARKRMLLLTTGPRLIYIDP 706
            :|:   .:|:.:.|.|::|  :.||.|.:..:|.|.|.|:||||||||:|.||||.||.|.|:||
Zfish   413 ELDLQFSSEEKRLLLQKQTSGNPWHQFVENNLIYKMGPVDKRKGLFARRRQLLLTEGPHLYYVDP 477

  Fly   707 VQMIKKGEIPWSPDLRAEYKNFKIFFVHTPNRTYYLDDPEGYAIHWSEAIENM 759
            |..:.||||||||:||.|.||||.||||||||||||.||.|.|..|.:.|:.:
Zfish   478 VNKVLKGEIPWSPELRPEAKNFKTFFVHTPNRTYYLMDPSGNADKWCKKIQEV 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdk1	NP_001261183.1	STKc_PDK1	244..571	CDD:270733	131/326 (40%)
		S_TKc	246..571	CDD:214567	130/324 (40%)
		PH_PDK1	658..764	CDD:241293	62/104 (60%)
pdpk1a	NP_001070812.1	STKc_PDK1	75..337	CDD:270733	131/326 (40%)
		S_TKc	77..324	CDD:214567	127/311 (41%)
		PH_PDK1	429..531	CDD:241293	61/102 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575908
Domainoid	1	1.000	134	1.000	Domainoid score	I4968
eggNOG	1	0.900	-	-		E1_KOG0592
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	445	1.000	Inparanoid score	I1612
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1157543at2759
OrthoFinder	1	1.000	-	-		FOG0001781
OrthoInspector	1	1.000	-	-		otm24855
orthoMCL	1	0.900	-	-		OOG6_101713
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2717
SonicParanoid	1	1.000	-	-		X1315
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790