DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdk1 and trc

DIOPT Version :9

Sequence 1:	NP_001261183.1	Gene:	Pdk1 / 38017	FlyBaseID:	FBgn0020386	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster

Alignment Length:	425	Identity:	118/425 - (27%)
Similarity:	201/425 - (47%)	Gaps:	68/425 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 YQNDIRQQTEILDMLRQQHQQGYQSQQQQQQPQQQQEQQQQQEQSQQQ-QQLQNPAPRRSPNDFI 247
            |.|.:.|..|     |:|.....::|.:.:...:.|.|:::.:.:|:: :.|:....|....||.
  Fly    35 YSNLVTQYGE-----RKQRLAKLEAQLKDESLSEAQRQEKRLQHAQKETEYLRLKRLRLGVEDFE 94

  Fly   248 FGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVM----HQMTNVPGFV 308
            ..:.||.|::..|.|.....:...||:||..|..:|.:.:..:::.||:|:    ||..     |
  Fly    95 ALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEADHQWV-----V 154

  Fly   309 NLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKP 373
            .:..:|||..:||.:|.:...|||:..:.:..:.....|:.|.:|..||.:.:|:...:|||:||
  Fly   155 KMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIHRDIKP 219

  Fly   374 ENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSE 438
            :|:|||...|..::|||.               |:..::|:.              .||| ||..
  Fly   220 DNLLLDARGHLKLSDFGL---------------CTGLKKSHR--------------TDFY-RDLS 254

  Fly   439 ELDDGD-----DEQQQEEMDSPRHRQRRYNRHRKA---SFVGTAQYVSPEV-LQNGPITPAADLW 494
            :....|     .......|||.| |...:.|:|:|   |.|||..|::||| ||.| ..||.|.|
  Fly   255 QAKPSDFIGTCASLSCSPMDSKR-RAESWKRNRRALAYSTVGTPDYIAPEVFLQTG-YGPACDWW 317

  Fly   495 ALGCIVYQMIAGLPPFRGSNDYVIFKEILDC--AVDFPQGF---DKDAEDLVRKLLRVDPRDRLG 554
            :||.|:|:|:.|.|||...|....::::::.  .:.||...   ::..|.::......|  .|||
  Fly   318 SLGVIMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEIPISEEAKETIINFCCEAD--RRLG 380

  Fly   555 AQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYP 589
            :|...   |.:::.|||.|:||:.:|::  |...|
  Fly   381 SQRGL---EDLKSVPFFRGVDWEHIRER--PAAIP 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdk1	NP_001261183.1	STKc_PDK1	244..571	CDD:270733	98/344 (28%)
		S_TKc	246..571	CDD:214567	97/342 (28%)
		PH_PDK1	658..764	CDD:241293
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	11/54 (20%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	106/364 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010