Protein Alignment Pdk1 and Pka-C3

DIOPT Version :10

• Sequence 1: NP_728471.2
• Gene: Pdk1 / 38017
• FlyBaseID: FBgn0020386
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_730083.2
• Gene: Pka-C3 / 39733
• FlyBaseID: FBgn0000489
• Length: 583
• Species: Drosophila melanogaster
• Alignment Length: 635
• Identity: 145/635 - (22%)
• Similarity: 255/635 - (40%)
• Gaps: 152/635 - (23%)

  Fly    37 ASGIAAAAVITVASDCGENCSSNGT---------EHQQHFNIATTTATSATEAT--MPAMAKEKA 90
            |||:.|.  :...:..|:....|||         :.|.....|.:|||.|...|  ....|...:
  Fly    43 ASGLRAG--LATPTQRGKATGDNGTTGTPARTIGKPQARIATAMSTATCARFCTPLSSGTAGSTS 105

  Fly    91 SATVSLGESNFRDINLKDLAVVVEAASRLHHQQNVCGCGAVSSTENNNNSRYGSSKYLTNGHTS- 154
            ..|...|..|           .:.:|.:: ...|.......|:||.....:.|.|    ||.:|
  Fly   106 KLTTGNGSGN-----------TMTSAYKI-PSNNSTTANDSSNTETTFTFKLGRS----NGRSSS 154

  Fly   155 ---------PLAA----------------AVASNSSSVATTPHCRMLHNCSLQQYQNDIRQQTEI 194
                     ||.:                |..|.|||.|||.      ..|...:.||:.::.|.
  Fly   155 NVASSESSDPLESDYSEEDPEQEQQRPDPATNSRSSSTATTT------TTSSADHDNDVDEEDEE 213

  Fly   195 LDMLRQQHQQGY----------QSQQQQQQPQQQQEQQQQQEQSQQQQQLQNPAPRRS--PNDFI 247
            .|   :...:|.          .|:..::....:.:.::..::|::...:|.....|.  .:|:.
  Fly   214 DD---ENEGEGNGRDADDATHDSSESIEEDDGNETDDEEDDDESEESSSVQTAKGVRKYHLDDYQ 275

  Fly   248 FGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSC 312
            ..:.:|.|::..|.|..|..|.:..|:|:.....::|.::.:::|.||.::.::.: |..::|..
  Fly   276 IIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNILREIRH-PFVISLEW 339

  Fly   313 TFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENIL 377
            :.:|..:||.:..|...|::..|:...|.|....:..||||::.|.|::|...:|:|||||||:|
  Fly   340 STKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLL 404

  Fly   378 LDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDD 442
            ::.|.|..|.|||.||.:
  Fly   405 INRDGHLKITDFGFAKKL----------------------------------------------- 422

  Fly   443 GDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGL 507
                                 |.|..:..||.:|::||::|:.....|.|.||||.::|:|:.|.
  Fly   423 ---------------------RDRTWTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGY 466

  Fly   508 PPFRGSNDYVIFKEILDCAVDFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFA 572
            |||.....:.|:::||...:::.:..|..|:||::|||..|...|||......  :.::.|.:|.
  Fly   467 PPFYDEQPFGIYEKILSGKIEWERHMDPIAKDLIKKLLVNDRTKRLGNMKNGA--DDVKRHRWFK 529

  Fly   573 GIDWQTLRQQTPPPIYPYLPGVSQDEDFRSSYTVP-GDLEP--GLDERQI 619
            .::|..:..:...|  |.||.|..|.|.::....| .|.:|  .:|:|.:
  Fly   530 HLNWNDVYSKKLKP--PILPDVHHDGDTKNFDDYPEKDWKPAKAVDQRDL 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdk1	NP_728471.2	STKc_PDK1	244..571	CDD:270733	82/326 (25%)
		PH_PDK1	658..764	CDD:241293
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	91/363 (25%)