Protein Alignment Pdk1 and STK38L

DIOPT Version :10

• Sequence 1: NP_728471.2
• Gene: Pdk1 / 38017
• FlyBaseID: FBgn0020386
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_055815.1
• Gene: STK38L / 23012
• HGNCID: 17848
• Length: 464
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 121/473 - (25%)
• Similarity: 222/473 - (46%)
• Gaps: 63/473 - (13%)

  Fly   158 AAVASNSSSVATTPHCR---MLHNCSLQQ-YQNDIRQQTEILDMLRQQHQQGYQ-SQQQQQQPQQ 217
            |..|..:::...:.|.|   .:...:|:. |.|.|.|..|     |:..|:..: :.:::....:
Human     2 AMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEE-----RETRQKKLEVAMEEEGLADE 61

  Fly   218 QQEQQQQQEQSQQQQQLQNPAPRRSPNDFIFGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLI 282
            :::.::.|...::.:.|:....|...:||...:.||.|::..|.|.....:...||:|:..|..:
Human    62 EKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDM 126

  Fly   283 LRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACT 347
            |.:.:..:|:.||:::.:.... ..|.:..:|||:|:||.:|.:...|||:..:.:..:.....|
Human   127 LEKEQVAHIRAERDILVEADGA-WVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEET 190

  Fly   348 RHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRR 412
            :.|.:|.:||.:.:|:...:|||:||:|:|||...|..::|||   :.|..::|    |.:|..|
Human   191 QFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFG---LCTGLKKA----HRTEFYR 248

  Fly   413 SNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQR-RYNRHRKA-SFVGTAQ 475
            :.:          .|...||               ..:.|:|.|..:. :.||.:.| |.|||..
Human   249 NLT----------HNPPSDF---------------SFQNMNSKRKAETWKKNRRQLAYSTVGTPD 288

  Fly   476 YVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFRGSNDYVIFKEILDC--AVDFPQ--GFDKD 536
            |::|||..........|.|:||.|:|:|:.|.|||........::::::.  .:.||.  ...:.
Human   289 YIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEK 353

  Fly   537 AEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYPY----LPGVSQD 597
            |:||:.:.. :|..:|:|...    .|.|:.||||.|:||:.:|::  |...|.    :...|..
Human   354 AKDLILRFC-IDSENRIGNSG----VEEIKGHPFFEGVDWEHIRER--PAAIPIEIKSIDDTSNF 411

  Fly   598 EDFRSS---YTVPGDLEP 612
            :||..|   ..||...||
Human   412 DDFPESDILQPVPNTTEP 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdk1	NP_728471.2	STKc_PDK1	244..571	CDD:270733	90/332 (27%)
		PH_PDK1	658..764	CDD:241293
STK38L	NP_055815.1	MobB_NDR_LATS-like	12..86	CDD:459252	13/78 (17%)
		S100B binding. /evidence=ECO:0000250	63..88		3/24 (13%)
		STKc_NDR2	87..452	CDD:270776	106/383 (28%)