Protein Alignment Pdk1 and Pdpk1

DIOPT Version :9

• Sequence 1: NP_001261183.1
• Gene: Pdk1 / 38017
• FlyBaseID: FBgn0020386
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_035192.2
• Gene: Pdpk1 / 18607
• MGIID: 1338068
• Length: 559
• Species: Mus musculus
• Alignment Length: 645
• Identity: 256/645 - (39%)
• Similarity: 339/645 - (52%)
• Gaps: 132/645 - (20%)

  Fly   153 TSPLAAAVASNSSSVATTPHCRMLHNCSLQQYQNDIRQQTEILDMLRQQHQQGYQ-------SQQ 210
            ||.|..||...||.|.          ||...           ..|:|.|.:.|..       |:|
Mouse     5 TSQLYDAVPIQSSVVL----------CSCPS-----------PSMVRSQTEPGSSPGIPSGVSRQ 48

  Fly   211 QQQQPQQQQEQQQQQEQSQQQQQLQNPAPRRS-PNDFIFGRYIGEGSYSIVYLAVDIHSRREYAI 274
            .........|.:......||......|.||:. |.||.||:.:||||:|.|.||.::.:.|||||
Mouse    49 GSTMDGTTAEARPSTNPLQQHPAQLPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAI 113

  Fly   275 KVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRV 339
            |:.|||.|::|.|..|:.|||:||.::.: |.||.|..||||...|||.::||:.|::|.||.::
Mouse   114 KILEKRHIIKENKVPYVTRERDVMSRLDH-PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKI 177

  Fly   340 GSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALAT 404
            ||||..|||.|.||::.|.|::|.:.::|||||||||||:||||..|.|||:|||:
Mouse   178 GSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVL--------- 233

  Fly   405 EHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKAS 469
                                                             ||..:|.|.|     |
Mouse   234 -------------------------------------------------SPESKQARAN-----S 244

  Fly   470 FVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFRGSNDYVIFKEILDCAVDFPQGFD 534
            |||||||||||:|.......::||||||||:||::|||||||..|:|:||::|:.....||:.|.
Mouse   245 FVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYHFPEKFF 309

  Fly   535 KDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYPYLPGVSQDED 599
            ..|.|||.|||.:|...|||.::..| |..::|||||..|.|:.|.|||||.:..|||.:|:|::
Mouse   310 PKARDLVEKLLVLDATKRLGCEEMEG-YGPLKAHPFFETITWENLHQQTPPKLTAYLPAMSEDDE 373

  Fly   600 --------------------FRSSYTVPGDLEPGLDERQISRLLSAELGVGSSVAMPVKRSTAKN 644
                                ..||::: ..:|..|.:|.           ||::...: .....|
Mouse   374 DCYGNYDNLLSQFGFMQVSSSSSSHSL-STVETSLPQRS-----------GSNIEQYI-HDLDTN 425

  Fly   645 SFDL----NDAEKLQRLEQQK-TDKWHVFADGEVILKKGFVNKRKGLFARKRMLLLTTGPRLIYI 704
            ||:|    ::.||...||:|. .:.||.|.:..:|||.|.|:||||||||:|.||||.||.|.|:
Mouse   426 SFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYV 490

  Fly   705 DPVQMIKKGEIPWSPDLRAEYKNFKIFFVHTPNRTYYLDDPEGYAIHWSEAIENMRKLAY 764
            |||..:.|||||||.:||.|.||||.||||||||||||.||.|.|..|...|:.:.:..|
Mouse   491 DPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQQY 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdk1	NP_001261183.1	STKc_PDK1	244..571	CDD:270733	141/326 (43%)
		S_TKc	246..571	CDD:214567	140/324 (43%)
		PH_PDK1	658..764	CDD:241293	62/106 (58%)
Pdpk1	NP_035192.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..83		12/68 (18%)
		STKc_PDK1	83..345	CDD:270733	141/326 (43%)
		S_TKc	85..345	CDD:214567	140/324 (43%)
		PIF-pocket. /evidence=ECO:0000250|UniProtKB:O15530	116..160		21/44 (48%)
		PH_PDK1	444..550	CDD:241293	61/105 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833227
Domainoid	1	1.000	129	1.000	Domainoid score	I5219
eggNOG	1	0.900	-	-		E1_KOG0592
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37643
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001781
OrthoInspector	1	1.000	-	-		oto92912
orthoMCL	1	0.900	-	-		OOG6_101713
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2717
SonicParanoid	1	1.000	-	-		X1315
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.730