DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdk1 and W04B5.5

DIOPT Version :9

Sequence 1:	NP_001261183.1	Gene:	Pdk1 / 38017	FlyBaseID:	FBgn0020386	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_497551.1	Gene:	W04B5.5 / 175360	WormBaseID:	WBGene00021022	Length:	320	Species:	Caenorhabditis elegans

Alignment Length:	380	Identity:	123/380 - (32%)
Similarity:	195/380 - (51%)	Gaps:	87/380 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 QQLQNP--APRRSPN-----DFIFGRYIGEGSYSIVYLAVDIHSRR---------EYAIKVCEKR 280
            :.|:||  |.|...|     |:...:.:||||:|.||||     ||         |.|:|:|.||
Worm     5 ENLKNPQNARREGSNMKCLADYSVEKEVGEGSFSTVYLA-----RRKEPKNDENPEVALKICLKR 64

  Fly   281 LILRERKQDYIKREREVMHQMTNV----PGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRV-- 339
            |||:.:...||.||:|.:..::..    ||.|.|..||||..|||||:.||:.||:...:.:.
Worm    65 LILKNKMVPYIHREKEALALISREENAHPGIVTLYATFQDSESLYFVLEYAKYGDLCTLMQKQPD 129

  Fly   340 GSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALAT 404
            ..|:||.:|:|||.||.|.||:|:..::|||:|.:|:|:..|...::.||||:|.::
Worm   130 SKFNVADSRYYAANLLSALEHIHKLGIIHRDVKADNLLVKSDGRIMLTDFGSSKFLS-------- 186

  Fly   405 EHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKAS 469
                                           |.:::.:...|::|.             ..|::|
Worm   187 -------------------------------DYQKIQENPVEEEQP-------------TGRRSS 207

  Fly   470 FVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFRGSNDYVIFKEILDCAVDFPQGF- 533
            |||||.:|:||:|....::|::||||....:|..:.|:.||...::|::|:.|.|....|.:.|
Worm   208 FVGTAFFVTPELLTGSEMSPSSDLWAFSVTLYLFLTGIYPFNDMSEYLVFRRIQDILYTFSEDFP 272

  Fly   534 DKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIY 588
            |::|::|:.:||..:.:.||.:|:       |:.|.||..||::.|.|..||.||
Worm   273 DENAKNLIERLLVKEQKSRLTSQE-------IKEHKFFESIDFEHLEQLEPPRIY 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdk1	NP_001261183.1	STKc_PDK1	244..571	CDD:270733	108/347 (31%)
		S_TKc	246..571	CDD:214567	106/340 (31%)
		PH_PDK1	658..764	CDD:241293
W04B5.5	NP_497551.1	PKc_like	25..303	CDD:389743	107/341 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0592
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1157543at2759
OrthoFinder	1	1.000	-	-		FOG0001781
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101713
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2717
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.810