Protein Alignment mthl8 and Adgrf4

DIOPT Version :10

• Sequence 1: NP_611998.1
• Gene: mthl8 / 38013
• FlyBaseID: FBgn0052475
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_084343.1
• Gene: Adgrf4 / 78249
• MGIID: 1925499
• Length: 698
• Species: Mus musculus
• Alignment Length: 396
• Identity: 85/396 - (21%)
• Similarity: 142/396 - (35%)
• Gaps: 136/396 - (34%)

  Fly   145 VETPCEHMKAVTKGSEYVHWTLHENGTISHRGHIFSKHYCFTPLLHGNSTWEWQPLACAPEKLYF 209
            |:..|.|.||||..|..:.....:|..::|                                :.|
Mouse   378 VKCRCRHTKAVTSFSILMSSKPVKNTILNH--------------------------------ITF 410

  Fly   210 V-LGVREWTYAICLLIAILSMFIVLMVYLMCSEMRNSFYGVAIKAYAICMI-LGYALLAYLTLHN 272
            : |.:..::..:||:|..:....|::..:  |.||:           :|:: :..:||.
Mouse   411 IGLSISIFSLVLCLVIEAIVWSRVVVTEI--SYMRH-----------VCIVNIAVSLLT------ 456

  Fly   273 PANL-----SNAACRILPS---LALMNLVLSFYILS---FIAFKLYLSFYG--VVFTKLMFWLIF 324
             ||:     ||.:..:...   ...:..:..|:.||   ::.||..|..||  |||.::|
Mouse   457 -ANVWFIIGSNFSANVQEDHKWCVAVTFLCHFFFLSLFFWMLFKALLIVYGILVVFRRMM----- 515

  Fly   325 TPIVLVAVGWSFFVGFSYYGSRLIFG---------------GDTCWFDPRNWS---VMIYFYAPV 371
             ...::|:|  |.:|   ||..|:..               .|.||.   ||:   .:..|..|.
Mouse   516 -KSRMMAIG--FAIG---YGCPLVIAVITVTVTEPGEGYTRKDACWL---NWNQTKALFAFAIPA 571

  Fly   372 FVACAISGFFYVLSQIYIRDQPDIETEKSFE-----SIEKN------RFKSFWKYFGYTAVVWVV 425
            ....|:: ...||:......:|.|.:.||.:     .|.||      .....|. ||.|.::..|
Mouse   572 LAIVAVN-LLVVLAVAINTQRPLIGSSKSQDMAIVFRISKNVAILTPLLGLTWG-FGLTTLLEGV 634

  Fly   426 CICSFAFNYYWENRSHLNYAVSFCM--AFHGFAALYALIG--KNQQIQNFLR-RIDN--GEDTCE 483
                           ||.:.:.|.:  ||.||..|  |.|  .:.:|::.|| |:.:  |:....
Mouse   635 ---------------HLVFHIIFALLNAFQGFFIL--LFGTIMDHKIRDALRMRVSSLKGKSRAA 682

  Fly   484 NSVPLS 489
            ..|.||
Mouse   683 EKVSLS 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl8	NP_611998.1	Methuselah_N	30..202	CDD:429053	10/56 (18%)
		7tm_GPCRs	213..475	CDD:475119	68/309 (22%)
		TM helix 1	214..238	CDD:410628	4/23 (17%)
		TM helix 2	248..269	CDD:410628	3/21 (14%)
		TM helix 5	360..383	CDD:410628	5/25 (20%)
		TM helix 6	409..431	CDD:410628	5/21 (24%)
		TM helix 7	434..465	CDD:410628	10/34 (29%)
Adgrf4	NP_084343.1	GPS	352..394	CDD:460350	8/15 (53%)
		7tm_GPCRs	402..669	CDD:475119	70/351 (20%)
		TM helix 1	405..429	CDD:320660	6/55 (11%)
		TM helix 2	444..465	CDD:320660	5/38 (13%)
		TM helix 3	479..501	CDD:320660	5/21 (24%)
		TM helix 4	522..538	CDD:320660	6/20 (30%)
		TM helix 5	560..583	CDD:320660	3/23 (13%)
		TM helix 6	609..631	CDD:320660	6/22 (27%)
		TM helix 7	636..661	CDD:320660	9/26 (35%)