Protein Alignment mthl8 and mthl10

DIOPT Version :10

• Sequence 1: NP_611998.1
• Gene: mthl8 / 38013
• FlyBaseID: FBgn0052475
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_788446.2
• Gene: mthl10 / 38057
• FlyBaseID: FBgn0035132
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 130/534 - (24%)
• Similarity: 224/534 - (41%)
• Gaps: 94/534 - (17%)

  Fly     4 FC---ILGVLLIL---------SGTHCSWGFHEETHY--------PCAFIDTANITGSYGL--DG 46
            :|   :||||.::         .||:.   ..|..||        ||.|.||.|:|| :.|  :|
  Fly    13 YCGVTLLGVLCLVVFRLIPGIPFGTYV---MAERDHYHTIDDPNVPCNFYDTVNLTG-HRLFPNG 73

  Fly    47 PFVHNWTVIPRHFVAVYDFVIENGI--RIPASRHLRACVCKTKPCVRICCLRGEIYDLEKRQCLV 109
            .:.:..|::|...|..||: |.:.:  ||....|:|.||||.|.|:.|||...::::.|...|::
  Fly    74 SYDYYGTIVPAELVGTYDY-IHSSLTERIEVREHVRGCVCKFKSCLNICCPWRQVFNSEVDGCII 137

  Fly   110 PVAGVSSLPSHSHMEVELGNGSLRLVKLQPRFSIHVETPCEHMKAV-TKGSEYVHWTLHENGT-- 171
            ..:...:.|....:.:...|.|..||.:..:|:|....||..|.:: .:.:.:..:.|.|||:
  Fly   138 DHSDNRTWPDPPMLNITFRNESTILVNMFTQFAIQSFRPCPKMFSLQPETNNWDDYLLFENGSML 202

  Fly   172 -ISHRGHIFSKHYCFTPLLHGNST--WEWQPLACAPEKLYFVLGVREWTYAICLLIAILSMFIVL 233
             :..:..|....:|..|.....|.  :...|..|..:..:..:.:.. :||  ::.:|..|.:.:
  Fly   203 RVDDKLLIRKNEFCMVPTYVNESDMFYTIHPANCDMQDDHSTVKIIN-SYA--MMFSIPFMMLTI 264

  Fly   234 MVYLMCSEMRNSFYGVAIKAYAICMILGYALLAYLTLHNPANLSNAACRILPSLALMNLVLSFYI 298
            .|||:..|:||. :|.::..|.|.:.:||:.|.|:.|:. .:.:...|::....|....:.::..
  Fly   265 AVYLLIPELRNQ-HGKSLVCYLIGLSVGYSSLCYVQLYQ-VDATGVTCKVFGYTAYFFFMGAYMW 327

  Fly   299 LSFIAFKLYLSFYGV------------VFTKLMFWLIFTPIVLVAVGWSFFVGFSYYGSRL---- 347
            ||.|:|.|:.:|.|.            :|..|..|    .|.||      |:.|:|...:|
  Fly   328 LSVISFDLWHNFRGTRGINRFQEKKRFLFYSLYSW----GIALV------FLAFTYCAQQLTNLP 382

  Fly   348 ------IFGGDTCWFDPRNWSVMIYFYAPVFVACAISGFFYVLSQIYI--------------RDQ 392
                  |..|..||.|..||:.|||||.|:......:...::::.|.|              ...
  Fly   383 ANLKPGIGDGVYCWLDMSNWAAMIYFYGPILAIVVANTIMFIMTAIKIHGVQREMARIIASENST 447

  Fly   393 PDIETEKS---FESIEKNRFKSFWKYFGYTAVVWVVCICSF--AFNYYWENRSHLNYAVSFCMAF 452
            .::.|||.   :.:....||..|.:.|....:.|:..:.|:  ..:..|   |.|.|......|.
  Fly   448 KNLRTEKDKRFYRAWSNYRFGLFLRLFLIMGITWLTELISYFVGSDKGW---SKLFYISDLANAM 509

  Fly   453 HGFAALYALIGKNQ 466
            .||......:.|.:
  Fly   510 QGFLIFMLFVMKKK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl8	NP_611998.1	Methuselah_N	30..202	CDD:429053	49/181 (27%)
		7tm_GPCRs	213..475	CDD:475119	69/295 (23%)
		TM helix 1	214..238	CDD:410628	6/23 (26%)
		TM helix 2	248..269	CDD:410628	7/20 (35%)
		TM helix 5	360..383	CDD:410628	8/22 (36%)
		TM helix 6	409..431	CDD:410628	5/23 (22%)
		TM helix 7	434..465	CDD:410628	7/30 (23%)
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:429053	49/181 (27%)
		7tmB3_Methuselah-like	242..533	CDD:410632	69/300 (23%)
		TM helix 1	244..269	CDD:410632	6/27 (22%)
		TM helix 2	278..300	CDD:410632	7/21 (33%)
		TM helix 3	311..338	CDD:410632	6/26 (23%)
		TM helix 4	354..374	CDD:410632	8/29 (28%)
		TM helix 5	401..430	CDD:410632	9/28 (32%)
		TM helix 6	446..489	CDD:410632	9/42 (21%)
		TM helix 7	497..522	CDD:410632	6/24 (25%)