DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl8 and mthl9

DIOPT Version :9

Sequence 1:	NP_001261182.1	Gene:	mthl8 / 38013	FlyBaseID:	FBgn0052475	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_612029.1	Gene:	mthl9 / 38056	FlyBaseID:	FBgn0035131	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	140/460 - (30%)
Similarity:	215/460 - (46%)	Gaps:	29/460 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 HYPCAFIDTANITGSYGL-DGPFVHNWTVIPRHFVAVYDFVIENGIRIPASRHLRACVCKTKPCV 90
            ::|||:..|.|||....: ||.:.:...|:|.|.:|.|.|.:.:|:...|.:|||.|||..|||:
  Fly    26 NHPCAYAHTVNITDGLRMKDGSYSYAGVVVPPHLMAEYSFKVIDGVEYRAKKHLRGCVCLLKPCI 90

  Fly    91 RICCLRGEIYDLEKRQCLVPVAGVSSLPSHSHMEVELGNGSLRLVKLQPRFSIHVETPCEHMKAV 155
            ..||....::|.:...|.:|    ..:...:|:|:...|.::..|:::.||.:..|..|.:....
  Fly    91 SFCCPENLVFDAKHWNCTMP----HQVRESTHVELTYANRTVDQVRIRDRFVVRTELGCRNKFVD 151

  Fly   156 TKGSEYVHWTLHENGTISHRGHIFS-KHYCFTPLLHGNSTWEWQPLACAPEKLYFVLGVREWTYA 219
            .|...:..|.|.||||:.....::| ..|||:||.|....||..||.|  |:  |..|.|.|.||
  Fly   152 KKHDNFWQWDLFENGTLRRDNRLWSTDEYCFSPLEHNPEQWELTPLNC--ER--FQTGYRVWIYA 212

  Fly   220 ICLLIAILSMFIVLMVYLMCSEMRNSFYGVAIKAYAICMILGYALLAYLTLHNPANLSNAACRIL 284
            ||.:|||:....:|.:.....:.|.|.||..|..|.:.||:||:||.||.|.||..||:.|||.:
  Fly   213 ICSIIAIIINIFILSLLGSVRDARKSHYGQLIIYYLLSMIVGYSLLVYLALKNPMKLSHVACRNI 277

  Fly   285 PSLALMNLVLSFYILSFIAFKLYLSFYGVVFTKLMFWLIFTPIVLVAVGWSFFVGFSYYGSRLI- 348
            ..||...::|||..|:..:....|.|........:..|.....||..:|..|.|..: ..|:|.
  Fly   278 GFLAYFCIMLSFVFLAICSLDFLLKFKQKAVRSSVRRLSLALAVLAVIGLRFLVSLA-QDSKLPK 341

  Fly   349 -----FGGDTCWFDPRNWSVMIYFYAPV------FVACAISGFFYVLSQIYIRDQPDIETEKSFE 402
                 .|.|.||||.|.|.::||:|.|:      .:.|.:..:|.:...     .||.:.....:
  Fly   342 HFKPGMGEDYCWFDVRTWGILIYYYGPIALLLIFSIVCCLKAYFSIYEL-----PPDTQYILGTQ 401

  Fly   403 -SIEKNRFKSFWKYFGYTAVVWVVCICSFAFNYYWENRSHLNYAVSFCMAFHGFAALYALIGKNQ 466
             .|.|..|.:|..|......||:..|..:......|:...:::....|:.....|....|:|||.
  Fly   402 LKIVKTHFYAFSAYIVGVFAVWIREIVVYIMARVREHFFIIDFWSGICILGLAIAGFILLLGKNL 466

  Fly   467 QIQNF 471
            .::::
  Fly   467 HVKSW 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl8	NP_001261182.1	Methuselah_N	30..202	CDD:284145	56/173 (32%)
mthl9	NP_612029.1	Methuselah_N	29..199	CDD:284145	56/173 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469267
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.950