DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl8 and mthl3

DIOPT Version :9

Sequence 1:	NP_001261182.1	Gene:	mthl8 / 38013	FlyBaseID:	FBgn0052475	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	112/500 - (22%)
Similarity:	205/500 - (41%)	Gaps:	84/500 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CAFIDTANIT-------GSYGLDGPFVHNWTVIPRHFVAVYDF-VIENGIRIPASRHLRACVCKT 86
            |.|.||.:|:       |||..:|      .:||.|..|.||: ::.:..:...:.|:|.|.|..
  Fly    26 CDFFDTVDISKAPRFSNGSYLYEG------LLIPAHLTAEYDYKLLADDSKEKVASHVRGCACHL 84

  Fly    87 KPCVRICCLRGEIYDLEKRQCLVPVAGVSSLPSHS-HMEVELGNGSLRLVKLQPRFSIHVETP-- 148
            :||:|.||  .:...::|.:|...:: ...|..|. .:.|.|.:||  :|:...:..:.|::.
  Fly    85 RPCIRFCC--PQYQKMQKSKCYGDMS-EDELNKHDPFVNVTLSDGS--VVRRHFKEDLIVQSDLA 144

  Fly   149 ---CEHMKAVT---KGSEYVHWTLHENGTISH---RGHIFSKHYCFTPLLHGNSTWEWQPLACAP 204
               |..|..:.   .|:|:   ||.|||::..   :..:..:.||...|...:.:....|..|..
  Fly   145 KPGCPRMYFLNHELPGNEF---TLFENGSLLRHWDKVELSKREYCVQHLSFKDDSIRIAPHFCPL 206

  Fly   205 EKLYFVLGVREWTYAICLLIAILSMFIVLMVYLMCSEMRNSFYGVAIKAYAICMILGYALLAYLT 269
            ...:    .|.|. .:.::|:::.:.:.:.|||...::|| .:|.....|...:.|||..|..
  Fly   207 SSEH----SRTWK-TVAIVISLICIILTISVYLYVEKLRN-LHGKCFICYLASLFLGYFFLVL-- 263

  Fly   270 LHNPANLSNAACRILPSLALMNLVLSFYILSFIAFKLYLSFYGVVFTKLMFWL-------IFTPI 327
              |....|:..|.....|...:::.:|:.||.|:..|:.||.|     ...||       .|...
  Fly   264 --NVWKYSSGFCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSG-----NSSWLNRFLPQNRFLSY 321

  Fly   328 VLVAVGWSFFV-GFSYYGSRLIFG---------GDTCWFDPRNWSVMIYFYAPVFVACAISGFFY 382
            .|.|.|.:..: ..:|...:::..         |..||....:.:||||||.|:.:....:...:
  Fly   322 NLYAWGMALLLTAITYIADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLIIVFNITMF 386

  Fly   383 VLSQIYI-----RDQPDIETEKSFESI--EKNRFKSFWKYFGYTAVVWVVCICSFAFNYYWENRS 440
            ||:...|     ..|...:.:|:...:  :|..:..|.:.|....:.|.:.|.||..:   :|::
  Fly   387 VLTAFRIMKVKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLS---KNQA 448

  Fly   441 HLNYAVSFCMAFH-----GFAALYALIGKNQQIQNFLRRIDNGED 480
               :|.:|.:|.:     |.......:.:...::....||..|.|
  Fly   449 ---WAKAFMVADYFNWSQGTVIFLLFVLRPSTLKLLKERIKGGRD 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl8	NP_001261182.1	Methuselah_N	30..202	CDD:284145	47/191 (25%)
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	47/191 (25%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	50/229 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.020