Protein Alignment mthl8 and Dh44-R1

DIOPT Version :10

• Sequence 1: NP_611998.1
• Gene: mthl8 / 38013
• FlyBaseID: FBgn0052475
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_610960.1
• Gene: Dh44-R1 / 36601
• FlyBaseID: FBgn0033932
• Length: 504
• Species: Drosophila melanogaster
• Alignment Length: 442
• Identity: 84/442 - (19%)
• Similarity: 156/442 - (35%)
• Gaps: 121/442 - (27%)

  Fly   117 LPSHSHMEVELGNGSLRLVKLQPRFSIH--------VETPC---EHMKAVTKGSEYVH------- 163
            :..|:|::....:||      .|...:|        ||..|   ||::|.|.|::..|
  Fly     1 MSDHNHIDSVNASGS------DPLLDLHNLDGIGESVELQCLVQEHIEASTYGNDSGHCLTQFDS 59

  Fly   164 ---WTLHENGTIS-------HRGHIFSKHYCFTPLLHGNSTWEWQPL--AC----APE---KLYF 209
               |.....||::       .:|..:......|...|.|.|||....  ||    |||   :...
  Fly    60 ILCWPRTARGTLAVLQCMDELQGIHYDSSKNATRFCHANGTWEKYTNYDACAHLPAPESVPEFEV 124

  Fly   210 VLGVREWTYAICLLIAILSMFIVLMVYLMCSEMR--------NSFYGVAIKAYAICMILGYAL-- 264
            ::.:....|.|...::::|:.:.|:|:....|:|        |.|:...:.|....::|...:
  Fly   125 IVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFFTYIMSALFWILLLSVQISI 189

  Fly   265 -------LAYLTLHNPANLSNAACRILPSLALMNLVLSFYILSFIAFKLYLSFYGVVFTKLMFWL 322
                   :|.:||.:...|:|....::..|.|..||:..:....:.|.:|.|
  Fly   190 RSGVGSCIALITLFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYAS------------- 241

  Fly   323 IFTPIVLVAVGWS----FFVGFSYYGSRLIFGGDTCWFDPRNWSV---------MIYFYAPVFVA 374
                     :||.    |.|.::...|..:     .:..|..:.:         :.:.|.....|
  Fly   242 ---------IGWGGPALFVVTWAVAKSLTV-----TYSTPEKYEINCPWMQETHVDWIYQGPVCA 292

  Fly   375 CAISGFFYVLSQIYIRDQPDIETEKSFESIEKNRFKSFWKYFGYTAVVWVVCICSFAFNYY---- 435
            ..|....::|..:::.    |...:|..::|..:::.       .|...:|.|..|...|.
  Fly   293 VLIINLTFLLRIMWVL----ITKLRSANTVETRQYRK-------AAKALLVLIPLFGITYLVVLA 346

  Fly   436 WENRSHL---NYAV--SFCMAFHGFAALYALIGKNQQIQNFLR-RIDNGEDT 481
            ..:.|.|   .:||  :..::..||:........|.:::|.|| .|....||
  Fly   347 GPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTWRDT 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl8	NP_611998.1	Methuselah_N	30..202	CDD:429053	25/114 (22%)
		7tm_GPCRs	213..475	CDD:475119	51/301 (17%)
		TM helix 1	214..238	CDD:410628	5/23 (22%)
		TM helix 2	248..269	CDD:410628	3/29 (10%)
		TM helix 5	360..383	CDD:410628	3/31 (10%)
		TM helix 6	409..431	CDD:410628	3/21 (14%)
		TM helix 7	434..465	CDD:410628	7/39 (18%)
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	13/59 (22%)
		7tmB1_DH_R	126..394	CDD:320391	52/305 (17%)
		TM helix 1	128..153	CDD:320391	5/24 (21%)
		TM helix 2	162..184	CDD:320391	3/21 (14%)
		TM helix 3	197..224	CDD:320391	7/26 (27%)
		TM helix 4	236..256	CDD:320391	7/41 (17%)
		TM helix 5	279..308	CDD:320391	4/28 (14%)
		TM helix 6	322..349	CDD:320391	5/33 (15%)
		TM helix 7	356..381	CDD:320391	4/24 (17%)