DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl8 and Adgrl1

DIOPT Version :10

Sequence 1:NP_611998.1 Gene:mthl8 / 38013 FlyBaseID:FBgn0052475 Length:492 Species:Drosophila melanogaster
Sequence 2:XP_030099484.1 Gene:Adgrl1 / 330814 MGIID:1929461 Length:1543 Species:Mus musculus


Alignment Length:382 Identity:76/382 - (19%)
Similarity:140/382 - (36%) Gaps:76/382 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 GVSSLPSHSHMEVELGNGSLRLVKLQP-RFSI-HVETPCEHMKAVTKGSEYVHWTLHENGTISHR 175
            |.|.:.:...:...:...|.|:..:.| .|:: |:|.. .|..|     ....|...|...:.: 
Mouse   829 GASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEAK-NHFNA-----NCSFWNYSERSMLGY- 886

  Fly   176 GHIFSKHYCFTPLLHGNSTWEWQPLAC----------APEKLY------FVLGVREWTYAICLLI 224
               :|...|  .|:..|.|  ....||          |..::|      .:|.|..|   :.::|
Mouse   887 ---WSTQGC--RLVESNKT--HTTCACSHLTNFAVLMAHREIYQGRINELLLSVITW---VGIVI 941

  Fly   225 AILSMFIVLMVYLMCSEM---RNSFYGVAIKAYAICMILGYALLAYLTLHNPANLSNAACRILPS 286
            :::.:.|.:..:.....:   ||:.:      ..:|:.|..|.|.:|...:.... ..||.|...
Mouse   942 SLVCLAICISTFCFLRGLQTDRNTIH------KNLCINLFLAELLFLVGIDKTQY-EVACPIFAG 999

  Fly   287 LALMNLVLSFYILSFIAFKLYLSFYGVV---FTKLMFWLI----FTPIVLVAVGWSFFVGFSYYG 344
            |.....:.:|..|......|||....|.   :::..::.:    |..:|   ||.:..:.:..||
Mouse  1000 LLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALV---VGIAAAIDYRSYG 1061

  Fly   345 SRLIFGGDTCWFDPRN---WSVMIYFYAPV-FVACAISGFFYVLSQIYIRDQPDIETEKSFESIE 405
            :.     ..||....|   ||    |..|| ||......|..|.....||....::.:.|    .
Mouse  1062 TE-----KACWLRVDNYFIWS----FIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSS----R 1113

  Fly   406 KNRFKSFWKYFGYTAVVWVVCICSFAFNYYWENRSHLNYAVSFCMAFHGFAALYALI 462
            .:..|| |. .|..|:::::.: ::||...:.|:..:..|..| ..|:.|..::..:
Mouse  1114 LDNIKS-WA-LGAIALLFLLGL-TWAFGLLFINKESVVMAYLF-TTFNAFQGVFIFV 1166

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl8NP_611998.1 Methuselah_N 30..202 CDD:429053 17/90 (19%)
7tm_GPCRs 213..475 CDD:475119 54/264 (20%)
TM helix 1 214..238 CDD:410628 3/23 (13%)
TM helix 2 248..269 CDD:410628 4/20 (20%)
TM helix 5 360..383 CDD:410628 9/26 (35%)
TM helix 6 409..431 CDD:410628 5/21 (24%)
TM helix 7 434..465 CDD:410628 5/29 (17%)
Adgrl1XP_030099484.1 OLF 214..470 CDD:470611
PLN02550 491..>573 CDD:178165
HormR 548..611 CDD:214468
GAIN 621..845 CDD:465137 2/15 (13%)
GPS 869..921 CDD:197639 11/64 (17%)
7tmB2_Latrophilin-1 928..1185 CDD:320673 55/269 (20%)
TM helix 1 930..955 CDD:320673 5/27 (19%)
TM helix 2 964..986 CDD:320673 6/27 (22%)
TM helix 3 995..1022 CDD:320673 6/26 (23%)
TM helix 4 1034..1054 CDD:320673 4/22 (18%)
TM helix 5 1071..1100 CDD:320673 10/32 (31%)
TM helix 6 1116..1143 CDD:320673 7/29 (24%)
TM helix 7 1147..1172 CDD:320673 4/21 (19%)
Latrophilin 1184..1543 CDD:460538
Blue background indicates that the domain is not in the aligned region.

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