DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl8 and mthl15

DIOPT Version :9

Sequence 1:	NP_001261182.1	Gene:	mthl8 / 38013	FlyBaseID:	FBgn0052475	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_723538.3	Gene:	mthl15 / 318914	FlyBaseID:	FBgn0051720	Length:	718	Species:	Drosophila melanogaster

Alignment Length:	476	Identity:	99/476 - (20%)
Similarity:	166/476 - (34%)	Gaps:	128/476 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 IPASRHL-RAC----VCKTKPCVRICCLRGEIYDLEKRQCLVPVAGVS---------------SL 117
            :|..:.| |||    :|:..||:|.||..||:|..........:.|..               |.
  Fly   240 LPEQKFLVRACQEMKICQKIPCIRRCCAEGEMYAKGNFSTYCKIDGTDFKFEGFQNLNINANFSK 304

  Fly   118 PSHSHMEVELGNGSLRLVKLQ-PRFSIHVET-PCE-HMKAVTKGSEYVHWTLHENGTISHRGHIF 179
            ||    :..:.:|      || |:|.:..:. |.: |....:.||..:|.|...         ..
  Fly   305 PS----DFGIVHG------LQCPKFRLDPDNFPDDSHTINPSNGSLIIHNTFKT---------YT 350

  Fly   180 SKHYCFTPLLHGNSTWEWQPLACAPEKLYFVLGVREWTYAICLLIAILSMFIVLMVYLMCSEMRN 244
            :..||...:......:.:   .|...|:.....:|...|.|.|||:.....:.|:||:..:::||
  Fly   351 NTQYCVERVRPNQKLYTF---LCFDNKVVTGDRIRFKMYPIGLLISCCFYALTLIVYISIAKLRN 412

  Fly   245 SFYGVAIKAYAICMILGYALLAYLTLHNPANLSNAACRILPSLALMNLVLSFYILSFIAFKLYLS 309
                          :.|..|:..::....|.|..|..::.|:   .|..:.|....|:.|.|..:
  Fly   413 --------------LPGKILICLVSSLFAAYLGIALGQLRPT---SNDDICFLSGFFVYFCLMAA 460

  Fly   310 FYGVVFTKLMFWLIFTPIVLVAVGWS----FFVGFSYYG-----------------------SRL 347
            |..:..|....|..|....|.:...|    .|:.:|.||                       .|.
  Fly   461 FSWMNITSFDIWKTFGSTKLKSCEKSDLRRQFIWYSCYGWGLPTLLTGITIAFTKSDILPDAVRP 525

  Fly   348 IFGGDTCWF--DPRNWSVMIYFYAPVFVACAISGFFYVLSQIYIR--------------DQPDIE 396
            .||...|||  |....:.:::|..||.:...|:...:||:..|..              |:|.::
  Fly   526 NFGHGRCWFTYDSFGSASLLFFSGPVGILFIINLVLFVLTMKYCNKVKNEIYKMQSLNSDKPVLK 590

  Fly   397 TEKSFESIEKNRFKSFWKYFGYTAVVWVVCICSFAF-----NYYWENRSHLNYAVSFCMAFHGFA 456
             .:.|:  :|.||....|......:.|::.|.|..|     .::|          :...:|:...
  Fly   591 -RRFFQ--DKTRFVMNTKLCFVMGITWLLEIVSILFYDHKKTFFW----------TISDSFNVLL 642

  Fly   457 ALYALIGKNQQIQNFLRRIDN 477
            .::..|     |..|.|||.|
  Fly   643 GIFVFI-----IFVFKRRIYN 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl8	NP_001261182.1	Methuselah_N	30..202	CDD:284145	31/151 (21%)
mthl15	NP_723538.3	Mth_Ecto	<247..355	CDD:299804	27/126 (21%)
mthl15	NP_723538.3	7tm_4	385..646	CDD:304433	58/290 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.020