DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl8 and ADGRE2

DIOPT Version :10

Sequence 1:NP_611998.1 Gene:mthl8 / 38013 FlyBaseID:FBgn0052475 Length:492 Species:Drosophila melanogaster
Sequence 2:XP_054176753.1 Gene:ADGRE2 / 30817 HGNCID:3337 Length:892 Species:Homo sapiens


Alignment Length:455 Identity:87/455 - (19%)
Similarity:148/455 - (32%) Gaps:176/455 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   111 VAGVSSLPSHSHMEVELGNGSLRL---VKLQP--RFSIHVETPCEHMKAVTKG-----SEYVHWT 165
            |.|:.|:|         |.|.|..   :.|:|  :..:| ||   |...:..|     |:.:...
Human   470 VVGLVSIP---------GMGKLLAEAPLVLEPEKQMLLH-ET---HQGLLQDGSPILLSDVISAF 521

  Fly   166 LHENG----------TISHRGHIFSKHYCFTPLLHG-NSTWEWQPLACAPEKLYFVLGVREWTYA 219
            |..|.          |.|||..|..:........|| |....|....|:      .:|.|: |..
Human   522 LSNNDTQNLSSPVTFTFSHRSVIPRQKVLCVFWEHGQNGCGHWATTGCS------TIGTRD-TST 579

  Fly   220 IC-------------------------------LLIAILSMFIVLMVYLMCSEMRNSFYGVAIKA 253
            ||                               |.:::|.:.:..:.:|:|..::|:...:.:: 
Human   580 ICRCTHLSSFAVLMAHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQ- 643

  Fly   254 YAICMIL------------GYALLAYL---TLHNPANLSNAACRILPSLALMNLVLSFYILSFIA 303
            .::|:.|            |:.:|..:   |||. ..|:.....:|.:|.|.....:..::::.:
Human   644 LSLCLFLAHLLFLVAIDQTGHKVLCSIIAGTLHY-LYLATLTWMLLEALYLFLTARNLTVVNYSS 707

  Fly   304 FKLYLSFYGVVFTKLMFWLIF-TPIVLVAVGWSFFVGFSYYGSRLIFGGDT-CWFDPRN---WSV 363
            ...::.       ||||.:.: .|.|.||:        |......::|..: ||..|..   |. 
Human   708 INRFMK-------KLMFPVGYGVPAVTVAI--------SAASRPHLYGTPSRCWLQPEKGFIWG- 756

  Fly   364 MIYFYAPVFVACAISGFFYVLSQIYIRDQPDIETEKSFESIEKNRFKSFWKYFGYTAVVWVVCIC 428
               |..||   |||.....||                                 :...:|::   
Human   757 ---FLGPV---CAIFSVNLVL---------------------------------FLVTLWIL--- 779

  Fly   429 SFAFNYYWENR-SHLNYAVSF-----CMAFHGFAALYAL----------IGKNQQIQNFLRRIDN 477
                    :|| |.||..||.     .:||...|.|:.|          :|...::..:|..|.|
Human   780 --------KNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWCLGILQVGPAARVMAYLFTIIN 836

  Fly   478  477
            Human   837  836

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl8NP_611998.1 Methuselah_N 30..202 CDD:429053 26/111 (23%)
7tm_GPCRs 213..475 CDD:475119 57/328 (17%)
TM helix 1 214..238 CDD:410628 6/54 (11%)
TM helix 2 248..269 CDD:410628 4/35 (11%)
TM helix 5 360..383 CDD:410628 7/25 (28%)
TM helix 6 409..431 CDD:410628 1/21 (5%)
TM helix 7 434..465 CDD:410628 13/46 (28%)
ADGRE2XP_054176753.1 EGF_CA 136..168 CDD:429571
EGF_CA 188..>220 CDD:214542
EGF_CA 232..263 CDD:429571
EGF_CA 281..312 CDD:429571
GPS 548..598 CDD:197639 10/56 (18%)
7tmB2_EMR 602..864 CDD:320555 55/303 (18%)
TM helix 1 604..629 CDD:320555 2/24 (8%)
TM helix 2 638..660 CDD:320555 2/22 (9%)
TM helix 3 669..696 CDD:320555 7/27 (26%)
TM helix 4 713..733 CDD:320555 9/34 (26%)
TM helix 5 750..773 CDD:320555 9/62 (15%)
TM helix 6 797..822 CDD:320555 5/24 (21%)
TM helix 7 826..851 CDD:320555 3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

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