DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl8 and CG15744

DIOPT Version :9

Sequence 1:	NP_001261182.1	Gene:	mthl8 / 38013	FlyBaseID:	FBgn0052475	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_572870.2	Gene:	CG15744 / 2768909	FlyBaseID:	FBgn0030466	Length:	1797	Species:	Drosophila melanogaster

Alignment Length:	329	Identity:	58/329 - (17%)
Similarity:	106/329 - (32%)	Gaps:	99/329 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ILGVLLILSGTHCSWGFHEETHYPCAFIDTANITGSYGLDGPFVHNWTVIPRHFVAVYDFVIENG 70
            |||:.|:      .||.   ....|......|:......|..|:|:.|.:....|.....||..|
  Fly   885 ILGIYLV------GWGI---ALLICGISSAVNLAEYATYDYCFLHSSTTLNALLVPAVILVIFCG 940

  Fly    71 IRIPASRHLRACVCKTKPCVRICCLRGEIYDLEKRQCLVPVAGVSSLPSHSHMEVEL--GNGSLR 133
            |       |..|:........:..|:.::...:.||     ...::..:..|::::.  .|||..
  Fly   941 I-------LALCIYYQLSQQAVNVLQLQMQHQQNRQ-----YSDNNTQATEHIDLDWLDANGSAT 993

  Fly   134 LV------------KLQPRFSIHVETPCEHMKAVTKGSEYVHWTLHENGTISH-RGHIFSKHYCF 185
            ..            |.|........|....:.::...        .|...:|| ||     |:.|
  Fly   994 TAAIGGGSGNHGGRKEQDHMQEQYSTLSNPLSSIVDD--------FERSNLSHLRG-----HFIF 1045

  Fly   186 TPLLHGNSTWEWQPLAC---APEKLYFVLGVREWTYAICLLIAILSMFIVLMVYLMCSEMRNSFY 247
            ..|..|    .|...|.   ..::||.:      ::|.|  .::|.:|:::...|..::.|.::.
  Fly  1046 LVLYAG----AWLSAAAYVNGGQELYVL------SFAGC--CSVLGIFLLIFYNLSRNDARQAWS 1098

  Fly   248 ----GVAIKAYAI---------------------CMILGYALLAYLTLHNPANL----------S 277
                |.:|.|..:                     ..::..:::||.....|.:|          |
  Fly  1099 QGRDGRSIPAKLVTYNNGSQARGAHPSSMMPGPGTAMISNSIVAYKANPGPGSLYEANNSAGSRS 1163

  Fly   278 NAAC 281
            |:.|
  Fly  1164 NSQC 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl8	NP_001261182.1	Methuselah_N	30..202	CDD:284145	33/186 (18%)
CG15744	NP_572870.2	LRR_8	107..168	CDD:290566
		LRR_4	107..147	CDD:289563
		leucine-rich repeat	109..133	CDD:275378
		leucine-rich repeat	134..157	CDD:275378
		LRRCT	166..216	CDD:214507
		IG_like	229..344	CDD:214653
		HRM	<366..412	CDD:295297
		7tm_4	768..>975	CDD:304433	22/110 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462139
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930