Protein Alignment mthl8 and Adgrg2

DIOPT Version :10

• Sequence 1: NP_611998.1
• Gene: mthl8 / 38013
• FlyBaseID: FBgn0052475
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_852031.1
• Gene: Adgrg2 / 266735
• RGDID: 628618
• Length: 1013
• Species: Rattus norvegicus
• Alignment Length: 362
• Identity: 75/362 - (20%)
• Similarity: 125/362 - (34%)
• Gaps: 89/362 - (24%)

  Fly   162 VHWTLHENG-------------------TISHRGHIFSKHYCFTPLLHGNSTWEWQPLACAPEKL 207
            |.|.|:.||                   ||....|:.|    |..||..:.|      :..|.::
  Rat   567 VFWDLNRNGGRGGWSSDGCSVKEKRMNETICTCSHLTS----FGILLDLSRT------SLPPSQM 621

  Fly   208 YFVLGVREWTYAICLLIAILSMFIVLMVYLMCSEMRNSFYG-VAIKAYAICMILGYALL--AYLT 269
            ..:..:   ||..|.|.:|. :.:.|:.|:...::|..:.. :.|:..|..::|....|  :::.
  Rat   622 MALTFI---TYIGCGLSSIF-LSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIA 682

  Fly   270 LHNPANLSNAACRILPSLALMNLVLSFYILSFIAFKLYLSFYGVVFTKLMFWLIFTPIVLVAVGW 334
            |:|    :...|..:.......|::||..:...||.:||:...|..|.:..::    :....|||
  Rat   683 LYN----ARGFCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYI----LKFCIVGW 739

  Fly   335 SF--------------FVGFSYYGSRLIFGG----DTCWFDPRNWSVMIYF----YAPVFVACAI 377
            ..              ..|...||.   |..    |.||.   |.||:.|.    |..|.....:
  Rat   740 GIPAVVVSIVLTISPDNYGIGSYGK---FPNGTPDDFCWI---NSSVVFYITVVGYFCVIFLLNV 798

  Fly   378 SGFFYVLSQIYIRDQPDIETEKSFESIEKNRFKSFWKYFGYT---AVVWVVCICSFAFNYYWENR 439
            |.|..||.|:.     .|:.:|...:..|...:......|.|   .:.|     .||| :.| ..
  Rat   799 SMFIVVLVQLC-----RIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITW-----GFAF-FAW-GP 851

  Fly   440 SHLNYAVSFCM--AFHGFAALYALIGKNQQIQNFLRR 474
            .:|.:...|.:  ...||..........:.::...||
  Rat   852 VNLTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRR 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl8	NP_611998.1	Methuselah_N	30..202	CDD:429053	13/58 (22%)
		7tm_GPCRs	213..475	CDD:475119	61/292 (21%)
		TM helix 1	214..238	CDD:410628	7/23 (30%)
		TM helix 2	248..269	CDD:410628	4/23 (17%)
		TM helix 5	360..383	CDD:410628	8/26 (31%)
		TM helix 6	409..431	CDD:410628	3/24 (13%)
		TM helix 7	434..465	CDD:410628	5/32 (16%)
Adgrg2	NP_852031.1	GPS	564..608	CDD:460350	10/44 (23%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	566..615		13/57 (23%)
		Stachel. /evidence=ECO:0000250|UniProtKB:Q8CJ12	604..615		5/20 (25%)
		7tmB2_GPR64	621..890	CDD:320560	61/298 (20%)
		TM helix 1	623..648	CDD:320560	7/28 (25%)
		TM helix 2	658..680	CDD:320560	4/21 (19%)
		TM helix 3	691..718	CDD:320560	6/26 (23%)
		TM helix 4	733..749	CDD:320560	3/15 (20%)
		TM helix 5	779..802	CDD:320560	6/22 (27%)
		TM helix 6	825..850	CDD:320560	7/31 (23%)
		TM helix 7	854..879	CDD:320560	4/24 (17%)