DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl8 and ADGRF5

DIOPT Version :10

Sequence 1:NP_611998.1 Gene:mthl8 / 38013 FlyBaseID:FBgn0052475 Length:492 Species:Drosophila melanogaster
Sequence 2:XP_005248949.1 Gene:ADGRF5 / 221395 HGNCID:19030 Length:1386 Species:Homo sapiens


Alignment Length:490 Identity:89/490 - (18%)
Similarity:171/490 - (34%) Gaps:130/490 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ILGVLLILSGTHCSWGFHEETHYPCAFIDTANITGSYGLDGPFVHNWTVIPR----------HFV 60
            |:.:|.:||...........||    .:.|.|:.    |..|.::.|.|:.:          |.|
Human   813 IINILDLLSTVPTQVNSEMMTH----VLSTVNVI----LGKPVLNTWKVLQQQWTNQSSQLLHSV 869

  Fly    61 AVYDFVIENGIRIPAS-----RHLRACVCKTKPCVRICCLRGEIYDLEKR----------QCLVP 110
            ..:...:::|...|.|     ..:.:.|.|:.        ..|.|  ::|          ..::.
Human   870 ERFSQALQSGDSPPLSFSQTNVQMSSMVIKSS--------HPETY--QQRFVFPYFDLWGNVVID 924

  Fly   111 VAGVSSLPSHSHMEVELGNGSLRLVKLQPRFSIHVETPCEHMKAVTKGSEYVHWTLHENGTISHR 175
            .:.:.:|.|.|.: |.:...:|:.:..|   .|......|.:...|        |:..|.|:..|
Human   925 KSYLENLQSDSSI-VTMAFPTLQAILAQ---DIQENNFAESLVMTT--------TVSHNTTMPFR 977

  Fly   176 GHIFSKH--------YC-FTPLLHGNSTWEWQPLACAPEKLYFVLGVREWTYAICLLIAILSMFI 231
            ..:..|:        .| |......|:|..|....|..|:     |..:....||   ..|:.|.
Human   978 ISMTFKNNSPSGGETKCVFWNFRLANNTGGWDSSGCYVEE-----GDGDNVTCIC---DHLTSFS 1034

  Fly   232 VLM----------VYLMCSEMRNSFYGVAIKAYAICMILGYALLAYLTLHNPANLSNAAC--RIL 284
            :||          :.::...:.....|.:|.:.|.|:::...:...:| .|..:.....|  .|.
Human  1035 ILMSPDSPDPSSLLGILLDIISYVGVGFSILSLAACLVVEAVVWKSVT-KNRTSYMRHTCIVNIA 1098

  Fly   285 PSLALMN---LVLSF-----YIL---SFIAFKLYLSFYGVVFTKLMFW------LIFTPIVLV-- 330
            .||.:.|   :|::.     |||   :.:|...::.|:   :..:.||      ::|..:|.:  
Human  1099 ASLLVANTWFIVVAAIQDNRYILCKTACVAATFFIHFF---YLSVFFWMLTLGLMLFYRLVFILH 1160

  Fly   331 --------AVGWSFFVGFSYYGSRLIFGG----------DTCWFDPRNWSVMIYFYAP--VFVAC 375
                    |:.:....|.....|.:..|.          :.||.:..:...::.|..|  :.|..
Human  1161 ETSRSTQKAIAFCLGYGCPLAISVITLGATQPREVYTRKNVCWLNWEDTKALLAFAIPALIIVVV 1225

  Fly   376 AISGFFYVLSQIY---IRDQPDIETEKSFESIEKN 407
            .|:....|:::|.   |.|:|..:.:.|...|.|:
Human  1226 NITITIVVITKILRPSIGDKPCKQEKSSLFQISKS 1260

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl8NP_611998.1 Methuselah_N 30..202 CDD:429053 35/205 (17%)
7tm_GPCRs 213..475 CDD:475119 45/249 (18%)
TM helix 1 214..238 CDD:410628 6/33 (18%)
TM helix 2 248..269 CDD:410628 4/20 (20%)
TM helix 5 360..383 CDD:410628 4/24 (17%)
TM helix 6 409..431 CDD:410628
TM helix 7 434..465 CDD:410628
ADGRF5XP_005248949.1 SEA 179..281 CDD:470595
IG_like 285..361 CDD:214653
Ig strand B 289..293 CDD:409353
Ig strand C 301..305 CDD:409353
Ig strand E 333..337 CDD:409353
Ig strand F 347..351 CDD:409353
IG_like 517..602 CDD:214653
GPS 993..1036 CDD:460350 12/50 (24%)
7tmB2_GPR116_Ig-Hepta 1049..1323 CDD:320382 39/216 (18%)
TM helix 1 1051..1076 CDD:320382 4/24 (17%)
TM helix 2 1091..1113 CDD:320382 6/21 (29%)
TM helix 3 1127..1150 CDD:320382 4/25 (16%)
TM helix 4 1170..1186 CDD:320382 2/15 (13%)
TM helix 5 1208..1231 CDD:320382 4/22 (18%)
TM helix 6 1255..1280 CDD:320382 2/6 (33%)
TM helix 7 1285..1310 CDD:320382
Blue background indicates that the domain is not in the aligned region.

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