DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl8 and ADGRE1

DIOPT Version :10

Sequence 1:NP_611998.1 Gene:mthl8 / 38013 FlyBaseID:FBgn0052475 Length:492 Species:Drosophila melanogaster
Sequence 2:XP_011526096.1 Gene:ADGRE1 / 2015 HGNCID:3336 Length:978 Species:Homo sapiens


Alignment Length:319 Identity:56/319 - (17%)
Similarity:95/319 - (29%) Gaps:127/319 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   197 WQPLACAPEKLYFVLGVREWTYAIC------------------------------LLIAILSMFI 231
            |....|.      :|...| ||.||                              ::|:::.:.:
Human   654 WTSFGCV------ILEASE-TYTICSCNQMANLAVIMASGELTMDFSLYIISHVGIIISLVCLVL 711

  Fly   232 VLMVYLMCSEMRNSFYGVAIKAY-AICMILGYALLAYLT-LHNPANLSNAACRILPSLALMNLVL 294
            .:..:|:|..:||  :...:..: .:|::|...|  :|. :|...|  ...|.|:          
Human   712 AIATFLLCRSIRN--HNTYLHLHLCVCLLLAKTL--FLAGIHKTDN--KMGCAII---------- 760

  Fly   295 SFYILSFIAFKLYLSFYGVVFTKLMFWLIFTPIVLVAVGWSFFVGFSYYGSRLIFGGDTCWFDPR 359
                         ..|...:|....||::...::|..:                         .|
Human   761 -------------AGFLHYLFLACFFWMLVEAVILFLM-------------------------VR 787

  Fly   360 NWSVMIYFYAPVFVACAISGFFYVLSQIYI----RDQPD---------IETEKSFESIEKNRFKS 411
            |..|:.||.:.......|..|.|.|..:.:    ..||.         :.||..|          
Human   788 NLKVVNYFSSRNIKMLHICAFGYGLPMLVVVISASVQPQGYGMHNRCWLNTETGF---------- 842

  Fly   412 FWKYFGYTAVVWVVCICSFAFNY-YW---ENRSHLNYAVSF-----CMAFHGFAALYAL 461
            .|.:.|  .|..|:.|.|....: .|   :..|.:|..||.     .:.|..||.|:.|
Human   843 IWSFLG--PVCTVIVINSLLLTWTLWILRQRLSSVNAEVSTLKDTRLLTFKAFAQLFIL 899

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl8NP_611998.1 Methuselah_N 30..202 CDD:429053 1/4 (25%)
7tm_GPCRs 213..475 CDD:475119 53/303 (17%)
TM helix 1 214..238 CDD:410628 6/53 (11%)
TM helix 2 248..269 CDD:410628 3/21 (14%)
TM helix 5 360..383 CDD:410628 6/22 (27%)
TM helix 6 409..431 CDD:410628 6/21 (29%)
TM helix 7 434..465 CDD:410628 10/37 (27%)
ADGRE1XP_011526096.1 TM helix 3 758..785 CDD:320555 6/49 (12%)
TM helix 4 802..822 CDD:320555 4/19 (21%)
TM helix 5 839..862 CDD:320555 8/34 (24%)
TM helix 6 886..911 CDD:320555 5/14 (36%)
TM helix 7 915..940 CDD:320555
EGF_CA 33..62 CDD:238011
EGF_CA 80..114 CDD:214542
EGF_CA 132..171 CDD:214542
EGF_CA 172..206 CDD:214542
EGF_CA 224..260 CDD:214542
EGF_CA 264..297 CDD:214542
EGF_CA 313..>342 CDD:214542
EGF_CA 360..393 CDD:214542
GPS 638..687 CDD:197639 8/39 (21%)
7tmB2_EMR 691..953 CDD:320555 48/275 (17%)
TM helix 1 693..718 CDD:320555 1/24 (4%)
TM helix 2 727..749 CDD:320555 4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

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