DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mthl8 and Adgrl2

DIOPT Version :10

Sequence 1:NP_611998.1 Gene:mthl8 / 38013 FlyBaseID:FBgn0052475 Length:492 Species:Drosophila melanogaster
Sequence 2:NP_599235.3 Gene:Adgrl2 / 171447 RGDID:620835 Length:1487 Species:Rattus norvegicus


Alignment Length:426 Identity:73/426 - (17%)
Similarity:120/426 - (28%) Gaps:189/426 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   166 LHENGTISHRGHIF--------SKHYCFTPLL------------HGN-STWE---------WQPL 200
            |..|.||:...|:.        |:.|...|:|            :.| |.|.         |...
  Rat   745 LGRNSTIAVNSHVLSVSINKESSRVYLTDPVLFSMPHIDSDNYFNANCSFWNYSERTMMGYWSTQ 809

  Fly   201 AC------------------------APEKLYFVLGVREWTYAICLLIAILSMFIVLMVYLMCSE 241
            .|                        |..::.:..||.:      ||:.::: ::.::|.|:|  
  Rat   810 GCKLVDTNKTRTTCACSHLTNFAILMAHREIVYKDGVHK------LLLTVIT-WVGIVVSLVC-- 865

  Fly   242 MRNSFYGVAIKAYAICMILGYALLAYLTLHNPANLSNAACRILPSLALMNLVLSFYILSFI---- 302
                   :||..:..|...|        |.:..|..:           .||.::.:|..||    
  Rat   866 -------LAICIFTFCFFRG--------LQSDRNTIH-----------KNLCINLFIAEFIFLIG 904

  Fly   303 -----------AFKLYLSFYGVVFTKLMFWLIFTPIVL--------------------------- 329
                       .|...|.|:   |.....|:....:.|                           
  Rat   905 IDKTQYTIACPVFAGLLHFF---FLAAFSWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPA 966

  Fly   330 VAVGWSFFVGFSYYGSRLIFGGDTCWFDPRN---WSVMIYFYAPVFVACAISGFFYVLS------ 385
            ..||.|..:.:..||:.     :.||....|   ||    |..||.....::..|.|::      
  Rat   967 TVVGVSAAIDYKSYGTL-----EACWLHVDNYFIWS----FIGPVTFIILLNIIFLVITLCKMVK 1022

  Fly   386 ----------------------QIYIRDQPDIETEKSFESIEKNRFKSFWKYFGYTAVVWVVCI- 427
                                  ..|..|.|..|..|.|       .|| |....:.    ::|: 
  Rat  1023 HSNTLKPDSSRLENINNYRVCDGYYNTDLPGYEDNKPF-------IKS-WVLGAFA----LLCLL 1075

  Fly   428 -CSFAFNYYWENRSHLNYAVSFCMAFHGFAALYALI 462
             .:::|...:.|...:..|..| .||:.|..|:..|
  Rat  1076 GLTWSFGLLFVNEETVVMAYLF-TAFNAFQGLFIFI 1110

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl8NP_611998.1 Methuselah_N 30..202 CDD:429053 13/65 (20%)
7tm_GPCRs 213..475 CDD:475119 57/325 (18%)
TM helix 1 214..238 CDD:410628 3/23 (13%)
TM helix 2 248..269 CDD:410628 4/20 (20%)
TM helix 5 360..383 CDD:410628 7/25 (28%)
TM helix 6 409..431 CDD:410628 4/23 (17%)
TM helix 7 434..465 CDD:410628 8/29 (28%)
Adgrl2NP_599235.3 Gal_Rha_Lectin_LPHN2 36..132 CDD:438702
OLF 142..398 CDD:470611
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..462
HormR 469..533 CDD:214468
GAIN 542..764 CDD:465137 5/18 (28%)
GPS 788..840 CDD:197639 6/51 (12%)
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 792..841 5/48 (10%)
7tm_GPCRs 848..1129 CDD:475119 56/323 (17%)
TM helix 1 851..875 CDD:410628 5/33 (15%)
TM helix 2 884..905 CDD:410628 6/31 (19%)
TM helix 3 915..937 CDD:410628 5/24 (21%)
TM helix 4 956..972 CDD:410628 2/15 (13%)
TM helix 5 991..1014 CDD:410628 7/26 (27%)
TM helix 6 1065..1087 CDD:410628 2/25 (8%)
TM helix 7 1091..1116 CDD:410628 7/21 (33%)
Latrophilin 1128..1487 CDD:460538
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1139..1160
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1386..1428
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.