Protein Alignment mthl8 and LOC1276880

DIOPT Version :10

• Sequence 1: NP_611998.1
• Gene: mthl8 / 38013
• FlyBaseID: FBgn0052475
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: XP_061496511.1
• Gene: LOC1276880 / 1276880
• VectorBaseID: AGAMI1_002326
• Length: 1064
• Species: Anopheles gambiae
• Alignment Length: 507
• Identity: 119/507 - (23%)
• Similarity: 215/507 - (42%)
• Gaps: 86/507 - (16%)

  Fly     6 ILGVLLILSGTH---CSWGFHEETHYPCAFIDTANITGSYGLDGPFV-HNWTVIPRHFVAVYDFV 66
            |:..||:|.|..   ||        .||.|||:.|||....|....: ||..:..:.:..|.|:.
Mosquito     6 IVACLLVLFGVRSSVCS--------LPCDFIDSVNITDGERLPNDEIRHNGVIYNKTYYRVIDYD 62

  Fly    67 IEN-GIRIPASRHLRACVCKTKPCVRICCLRGEIYDLEKRQC---------LVPVAGVSSLPSHS 121
            .:: ..:.....::|.|:|..:.|||:||  ||...|.|| |         ||.|:...:
Mosquito    63 YQDFATKRYVPNYVRGCLCAVRICVRLCC--GEHEYLGKR-CTHTDDYLPILVNVSATEA----- 119

  Fly   122 HMEVELGNGSLRLVKLQPRFSIHVETPCEHM-KAVTKGSEYVHWTLHENGT--ISHRGHIFSKHY 183
               |:|.|.||        :......|||.: :.:.:.|....|::..||:  |:....|....|
Mosquito   120 ---VDLRNHSL--------YGFLYGKPCEQVYELLPEESPADEWSIARNGSLIIADELLIQRNQY 173

  Fly   184 CFTPLLHGNSTWEWQPLACAPEKLYFVLGVREWTYAICLLIAILSMFIVLMVYLMCSEMRNSFYG 248
            |..|..:....   ..|.|......|...:    |.:.:|:::..:.:...||....::|| .:|
Mosquito   174 CLAPRQNNGFA---SGLVCFTTNEEFKYNL----YPVGMLLSVPFLLLTFFVYACIPDLRN-MHG 230

  Fly   249 VAIKAYAICMILGYALLAYLTLHNPANLSNAACRILPSLALMNLVLSFYILSFIAFKLYLSFYGV 313
            .::..|.:.:.:||.:|:.:.|.....|| |:|.|...:...:.::||:.|:.::|.:|.:|.||
Mosquito   231 KSLMCYVLGLSVGYTVLSMVQLRVFPGLS-ASCVISGYIVYFSFMVSFFWLNVMSFDIYWTFKGV 294

  Fly   314 V------FTKLMFWLIFT---PIVLVAVGWSFFVGFS-----YYGSRLIFGGDTCWFDPRNWSVM 364
            .      ..|.:.:.::.   ||:|||.  :....::     |.  |..||...|.|........
Mosquito   295 TGVRSSETKKFLLYSLYAWGCPILLVAT--AIIADYTDILPIYL--RPQFGTTRCLFVENKLIEF 355

  Fly   365 IYFYAPVFVACAISGFFYVLS--QIY-------IRDQPDIETEKSFESIEKNRFKSFWKYFGYTA 420
            :|.|.|:.:...::..|:|::  :||       :..:.|.:.....:: :::||..:.:.|....
Mosquito   356 LYLYMPLLILVFMNVVFFVITALRIYKIQCETSVVRRGDSKRHTKLDN-DRDRFGLYLRLFIVMG 419

  Fly   421 VVWVVCICSFAFNYYWENRSHLNYAVSFCMAFHGFAALYALIGKNQQIQNFL 472
            |.|.:.|.|:|.    :|.:.:.|....|....|| .::||....|:|:..:
Mosquito   420 VTWSLEIISWAV----DNNAWIFYVSDVCNCIQGF-LIFALFVLKQKIKRLI 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl8	NP_611998.1	Methuselah_N	30..202	CDD:429053	47/185 (25%)
		7tm_GPCRs	213..475	CDD:475119	62/283 (22%)
		TM helix 1	214..238	CDD:410628	4/23 (17%)
		TM helix 2	248..269	CDD:410628	5/20 (25%)
		TM helix 5	360..383	CDD:410628	4/22 (18%)
		TM helix 6	409..431	CDD:410628	6/21 (29%)
		TM helix 7	434..465	CDD:410628	7/30 (23%)
LOC1276880	XP_061496511.1	None