Protein Alignment mthl8 and adgre14

DIOPT Version :10

• Sequence 1: NP_611998.1
• Gene: mthl8 / 38013
• FlyBaseID: FBgn0052475
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: XP_021330419.2
• Gene: adgre14 / 108182849
• ZFINID: ZDB-GENE-131120-49
• Length: 688
• Species: Danio rerio
• Alignment Length: 323
• Identity: 65/323 - (20%)
• Similarity: 116/323 - (35%)
• Gaps: 85/323 - (26%)

  Fly   205 EKLYFVLGVREWTYAICLLIAILSMFIVLMVYLMCSEMRNSFYGVAIKAYA---ICMILGYALLA 266
            :.|..||.|      :|:::.:|...:.|:.:..|.      :...:...|   ||:.|..|.|.
Zfish   397 DSLLNVLNV------VCVIVGLLFFSLALLTFTRCQ------WSPGVNNVARINICISLLLAHLL 449

  Fly   267 YLTLHNPANL---SNAACRILPSLALMNLVLSFYILSFI-AFKLYL----------SFYGVVFTK 317
            :|......:|   ....|.::..| |..|.||.::..|| |..|::          ....|:..|
Zfish   450 FLLTQQFLSLIRRQKVLCMLISGL-LHFLFLSGFVWMFIEAVLLFICVKNLSQISSQMKNVLRNK 513

  Fly   318 LMFWLIFTPIVLVAVGWSFFVGFSYYGSRLIFGGDTCWFDPRN---WSVMIYFYAPVFVACAISG 379
            |: .:|...:.||.|..|..|..:.|||      :.||.....   ||    |..||.:..|::.
Zfish   514 LL-CVIGYAVALVVVSISAAVVPNGYGS------EKCWIQMHKGFIWS----FLGPVTIIIALNV 567

  Fly   380 FFYV-----LSQIYIRDQPDIETEKSFESIEKNRFKSFWKYFGYTAVVWVVCICSFAFNYYWENR 439
            ..::     |...:.:...|:      ..:.:.:...|     .|...:||..||:...::..:.
Zfish   568 ILFISIGFSLKSAFKKLNADV------SQLNQTKIVMF-----KTLAQFVVLGCSWILGFFTNSS 621

  Fly   440 SHLNYA-------------VSFCMAFHG--------FAALYALIGKNQQIQNFLRRIDNGEDT 481
            ..|...             :.:|:...|        |.:||:    ..:.:||....:|.||:
Zfish   622 KVLEILFLILNSQQGTFIFLIYCVLNKGIRQEYRKLFTSLYS----GLKPKNFNWSSENTEDS 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl8	NP_611998.1	Methuselah_N	30..202	CDD:429053
		7tm_GPCRs	213..475	CDD:475119	59/307 (19%)
		TM helix 1	214..238	CDD:410628	3/23 (13%)
		TM helix 2	248..269	CDD:410628	6/23 (26%)
		TM helix 5	360..383	CDD:410628	6/25 (24%)
		TM helix 6	409..431	CDD:410628	6/21 (29%)
		TM helix 7	434..465	CDD:410628	6/51 (12%)
adgre14	XP_021330419.2	None