Protein Alignment mthl8 and adgrf8

DIOPT Version :10

• Sequence 1: NP_611998.1
• Gene: mthl8 / 38013
• FlyBaseID: FBgn0052475
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: XP_068071773.2
• Gene: adgrf8 / 100537224
• ZFINID: ZDB-GENE-130531-41
• Length: 1739
• Species: Danio rerio
• Alignment Length: 320
• Identity: 73/320 - (22%)
• Similarity: 106/320 - (33%)
• Gaps: 118/320 - (36%)

  Fly   220 ICLLIAIL---SMFIVLMVYLMCSEMRN-SFYGVAIKAYA--ICMILGYALLAYLTLHNPANLSN 278
            :||:|..:   |:.....|.::.|.||: |...:|:....  :|.|:|.|:   ..|..|..:.
Zfish  1427 LCLIIEAIVWRSVTSARGVTVVSSYMRHISLVNIALSLLIANVCFIIGAAI---SDLEKPTPVG- 1487

  Fly   279 AACRILPSLALMNLVLSFYILSFIAFKLYLSFYGVVFTKLMFWLIFTPIVLV------------- 330
               |..|            ::.||.|     ||..||    ||::.:.::|:
Zfish  1488 ---RCSP------------VVFFIHF-----FYLAVF----FWMLISGMLLLYMTVMVFGQMSRI 1528

  Fly   331 -AVGWSFFVGFSYYGSRLIFGGDT---------------CWFDPRNWS---VMIYFYAPVFVACA 376
             .:..||.||   ||:.|:....|               ||.   ||:   .::.|..|.....|
Zfish  1529 KMIAISFPVG---YGAPLLIASITVASTAGPQNYVSKQACWL---NWNESRALLAFVIPALTIVA 1587

  Fly   377 ISGFFYVL-------SQIYIRDQPDIETEKSFESIEKNRFKSFWKYFGYTAVVWVVCICSFAFNY 434
            |:....|:       :.:....||.          |||.|         ..||..|...:..|..
Zfish  1588 INLVVLVVVLYKMLGTGVGAATQPS----------EKNTF---------FVVVRCVAFLTPLFGL 1633

  Fly   435 YW------ENRSHLNYAVSFCM--AFHGFAALY-----------ALIGKNQQIQNFLRRI 475
            .|      ...|.|...|.|.:  ||.||..|.           ||.|| .||.....||
Zfish  1634 TWGFGIGTMLSSALGVHVLFTLLNAFQGFFILLFGTILDAKVREALRGK-LQIDKLTSRI 1692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl8	NP_611998.1	Methuselah_N	30..202	CDD:429053
		7tm_GPCRs	213..475	CDD:475119	71/318 (22%)
		TM helix 1	214..238	CDD:410628	5/20 (25%)
		TM helix 2	248..269	CDD:410628	5/22 (23%)
		TM helix 5	360..383	CDD:410628	6/25 (24%)
		TM helix 6	409..431	CDD:410628	4/21 (19%)
		TM helix 7	434..465	CDD:410628	13/49 (27%)
adgrf8	XP_068071773.2	None