DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl8 and gpr157

DIOPT Version :9

Sequence 1:	NP_001261182.1	Gene:	mthl8 / 38013	FlyBaseID:	FBgn0052475	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001124512.1	Gene:	gpr157 / 100038048	XenbaseID:	XB-GENE-492646	Length:	323	Species:	Xenopus tropicalis

Alignment Length:	219	Identity:	43/219 - (19%)
Similarity:	69/219 - (31%)	Gaps:	88/219 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 WQPLACAPEKLYFVLGVREWTYAICLLIAILSMF-------IVLMVYLMCSEMRNSFYGVAIKAY 254
            ||.|...|..|...|.|.:...|:.....:|..|       :........|...:.|:.||:..|
Frog    40 WQDLRSRPRLLLLFLSVADLLSALSYFYGVLRNFQDSTWDCVTQGAISTFSNTSSFFWTVAVAVY 104

  Fly   255 AICMILGYALLAYLTLHNPANLSNAACRILPSLALMN----LVLSFYILSFIAFKL--YLSFYGV 313
                       .|:|:  ..:..:.|.:|:|.|.|::    ||::   ||.:..|.  |.:.|
Frog   105 -----------LYITI--VKSQQSFADQIIPWLHLISWGVPLVIT---LSAVCLKKIGYDASY-- 151

  Fly   314 VFTKLMFWLIFTPIVLVAVGWSFFVGFSYYGSRLIFGGDTCW--FDPRN-----------WSVMI 365
                            |:|||                   ||  .|..:           |.::.
Frog   152 ----------------VSVGW-------------------CWVKIDVEDKLLWMLLAGKVWEILA 181

  Fly   366 YFYAPVFVACAISGFFYVLSQIYI 389
            |...||         .|:|.:.:|
Frog   182 YLILPV---------LYILIKKHI 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl8	NP_001261182.1	Methuselah_N	30..202	CDD:284145	3/4 (75%)
gpr157	NP_001124512.1	7tm_GPCRs	17..>192	CDD:391938	41/213 (19%)
		TM helix 1	17..39	CDD:341315
		TM helix 2	48..69	CDD:341315	4/20 (20%)
		TM helix 3	81..103	CDD:341315	4/21 (19%)
		TM helix 4	123..139	CDD:341315	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000