DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kr and AZF1

DIOPT Version :9

Sequence 1:	NP_001261181.1	Gene:	Kr / 38012	FlyBaseID:	FBgn0001325	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_014756.3	Gene:	AZF1 / 854280	SGDID:	S000005639	Length:	914	Species:	Saccharomyces cerevisiae

Alignment Length:	447	Identity:	119/447 - (26%)
Similarity:	174/447 - (38%)	Gaps:	105/447 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 SPLSTPL----------GSGKHPLNS---PNSTPQHHEPAKKARK----LSVKKEF-QTEISMSV 176
            |.:|.||          |..||...|   ||.       .||.:|    :.||.|. :|:..||.
Yeast   436 SAISRPLDKNDVIEGSEGLNKHIDESGMQPNI-------IKKRKKDDSTVYVKNEMPRTDPPMSK 493

  Fly   177 NDMYHTSGGPISPPSSGSSP-----NSTHDGAGGNAGCVGVSK----DPSRDKSFTCKICSRSFG 232
            ::.....|..:: ..||..|     :|..|.|....|...|.:    ..:|.|.||.|:.:...|
Yeast   494 DNSTSAEGAAMA-NFSGKEPPIPDISSVSDDATNLIGATKVDQLMLIIQARKKGFTEKVNTTQDG 557

  Fly   233 YKHVLQNH---------ERTHTGEKP-----------FECPECHKRFTRDHHLKTHMRLHTGEKP 277
              .:|.|.         |.....|||           .|||.||:.|::..||:.|:|.|.|.||
Yeast   558 --DLLFNQTMDILPPKSELVGGVEKPKGTQNTRAVKKHECPYCHRLFSQATHLEVHVRSHIGYKP 620

  Fly   278 YHCSHCDRQFVQVANLRRHLRVHTGERPYTCEICDGKFSDSNQLKSHMLVHNGEKPFEC--ERCH 340
            :.|.:|.::|.|..|||.|.|:||||:||:|:|||.|||....|.:|::.|...|||.|  |.|:
Yeast   621 FVCDYCGKRFTQGGNLRTHERLHTGEKPYSCDICDKKFSRKGNLAAHLVTHQKLKPFVCKLENCN 685

  Fly   341 MKFRRRHHLMNHKCGIQSPPTPALSPAMSGDYPVAISAIAIEASTNRFAAMCATYGGSN------ 399
            ..|.:..::..|:.........||:..::...|.....:........||::   |..||
Yeast   686 KTFTQLGNMKAHQNRFHKETLNALTAKLAEMNPSENIPLEERQLLEYFASI---YKNSNRGIKGR 747

  Fly   400 -ESVDMEKAT---PEDDGPLDLSEDGASSVDGHCSNIARRKAQDIRRVFRLPPPQIPHVPSDMPE 460
             :.|..:|:|   ||:        ..||::....:|.....|.|......      |....|...
Yeast   748 GKGVGTKKSTISSPEN--------HPASTILNPNTNANNAIANDSENNGN------PEGNIDSSS 798

  Fly   461 QTEPEDLSMHSP--RSIG-----------------SHEQTDDIDLYDLDDAPASYMG 498
            .:.|...||.||  :.:|                 |:.....|..|:....|.|.:|
Yeast   799 NSNPGSHSMISPTQKDMGTLQSQFIQNNFNNSVNSSNPSNQPIINYNYTTLPHSRLG 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr	NP_001261181.1	C2H2 Zn finger	224..244	CDD:275368	5/28 (18%)
		zf-H2C2_2	237..261	CDD:290200	12/43 (28%)
		C2H2 Zn finger	252..272	CDD:275368	9/19 (47%)
		zf-H2C2_2	264..289	CDD:290200	11/24 (46%)
		C2H2 Zn finger	280..300	CDD:275368	9/19 (47%)
		zf-H2C2_2	292..316	CDD:290200	16/23 (70%)
		C2H2 Zn finger	308..328	CDD:275368	9/19 (47%)
		zf-H2C2_2	321..345	CDD:290200	10/25 (40%)
		C2H2 Zn finger	336..352	CDD:275368	4/17 (24%)
AZF1	NP_014756.3	COG5048	342..768	CDD:227381	101/352 (29%)
		C2H2 Zn finger	595..615	CDD:275368	9/19 (47%)
		C2H2 Zn finger	623..643	CDD:275368	9/19 (47%)
		C2H2 Zn finger	651..671	CDD:275368	9/19 (47%)
		C2H2 Zn finger	679..702	CDD:275368	5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100