DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kr and topi

DIOPT Version :9

Sequence 1:NP_001261181.1 Gene:Kr / 38012 FlyBaseID:FBgn0001325 Length:502 Species:Drosophila melanogaster
Sequence 2:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster


Alignment Length:369 Identity:94/369 - (25%)
Similarity:143/369 - (38%) Gaps:83/369 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 LNSPNSTPQHHEPA--KKARKLSVKKEF-QTEISMSVNDMYHTSGGPISPPSSGSSPNSTHDGAG 204
            |.....|..|:.|.  :..:||.:..:| ......:.:.:.|:....::.........:|  |||
  Fly   444 LQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNT--GAG 506

  Fly   205 GNAGCVGVSKDPSRDKSFTCKICSRSFGYKHVLQNHERTHTGEKPFECPE--CHKRFTRDHHLKT 267
                         |.:.:.|.||.:|:.....|..|.|.|.|.|||.|.|  |.::||....|..
  Fly   507 -------------RIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLND 558

  Fly   268 HMR-LHTGEKPYHCSHCDRQFVQVANLRRHLRVHTGERPYTCEICDGKFSDSNQLKSHMLVHNGE 331
            |:| .||||:||.|..|.::|:..:...:|..:|.|||.|.||.|..:|..::.||:|..:|.||
  Fly   559 HIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGE 623

  Fly   332 KPFECERCHMKFRRR-----------HHL-MNHKCGIQSP----PTPALSPAMS----------- 369
            ||:.|..|...||:|           .|| .|.:..:|..    .|.|...|.|           
  Fly   624 KPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLETAAAQKAQSHNPEQQDNDVA 688

  Fly   370 -----GDYPVAISAIAIEAST----------NRFAAMCATYGGSNESVDME---KATP-EDDGP- 414
                 .|.|.....::.|.|.          .:...:|......|.|..|.   :|.| |:||. 
  Fly   689 GGASTSDVPSGSGFMSTEPSVAEMQYSITPEQQEEMVCVPIDEVNNSFFMSHYMQAVPMEEDGSG 753

  Fly   415 --LDLSEDGASSVD-------------GHCSNIARRKAQDIRRV 443
              :.:.|....::|             .|.|.:.:|.|::..||
  Fly   754 QHIIVFEQPGQNMDMMSIYDQQQVGEPMHESGVPKRPAEENARV 797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KrNP_001261181.1 C2H2 Zn finger 224..244 CDD:275368 7/19 (37%)
zf-H2C2_2 237..261 CDD:290200 12/25 (48%)
C2H2 Zn finger 252..272 CDD:275368 8/22 (36%)
zf-H2C2_2 264..289 CDD:290200 12/25 (48%)
C2H2 Zn finger 280..300 CDD:275368 4/19 (21%)
zf-H2C2_2 292..316 CDD:290200 9/23 (39%)
C2H2 Zn finger 308..328 CDD:275368 7/19 (37%)
zf-H2C2_2 321..345 CDD:290200 11/23 (48%)
C2H2 Zn finger 336..352 CDD:275368 7/27 (26%)
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275368
C2H2 Zn finger 277..297 CDD:275368
C2H2 Zn finger 431..453 CDD:275368 2/8 (25%)
COG5048 <450..647 CDD:227381 64/211 (30%)
C2H2 Zn finger 469..490 CDD:275368 2/20 (10%)
zf-C2H2 511..533 CDD:278523 7/21 (33%)
C2H2 Zn finger 513..564 CDD:275368 20/50 (40%)
C2H2 Zn finger 541..561 CDD:275368 7/19 (37%)
zf-H2C2_2 555..581 CDD:290200 12/25 (48%)
C2H2 Zn finger 572..592 CDD:275368 4/19 (21%)
zf-H2C2_2 585..609 CDD:290200 10/23 (43%)
zf-C2H2 598..620 CDD:278523 8/21 (38%)
C2H2 Zn finger 600..620 CDD:275368 7/19 (37%)
zf-H2C2_2 612..637 CDD:290200 11/24 (46%)
C2H2 Zn finger 628..646 CDD:275368 5/17 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24390
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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