DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kr and Sp5

DIOPT Version :9

Sequence 1:	NP_001261181.1	Gene:	Kr / 38012	FlyBaseID:	FBgn0001325	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001100022.1	Gene:	Sp5 / 296510	RGDID:	1308499	Length:	398	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	99/409 - (24%)
Similarity:	149/409 - (36%)	Gaps:	120/409 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AALAGIKQEDVHL---DRSMSLSPPMSANTSATSAAAIYPAMGLQQAAAASAF-------GMLSP 70
            ||:|.::.:.:..   ||:.|.||.:..::.....||....:|...||||..|       .:.||
  Rat     2 AAVAVLRNDSLQAFLQDRTPSASPDLGKHSPLALLAATCSRIGQPGAAAAPDFLQVPYDPALGSP 66

  Fly    71 TQL-------LAANRQAA-------------------AFMA--QLPMSTLANTLFPHN------- 100
            ::|       :.|:...|                   :|.|  :||::..|:..:|:.
  Rat    67 SRLFHPWTADMPAHSPGALPPPHPSLGLTPQKTHLQPSFGAAHELPLTPPADPSYPYEFSPVKML 131

  Fly   101 -------PAALFGA---WAAQQSLPPQGTHLHSPPASPHSPLSTPLGSGKHPLNSPNSTPQHHEP 155
                   ||:...|   :|||.:|||..::|..||..|..|   |......|..:|:..|....|
  Rat   132 PSSMAALPASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPP---PTCRQLSPAPAPDDLPWWSIP 193

  Fly   156 AKKARKLSVKKEFQTEISMSVNDMYHTSGGP--------ISPPSSGSSPNSTHDGAGGNAGCV-G 211
            ...|...|                   ||.|        ..||.:...|.|....|...|... |
  Rat   194 QSGAGPGS-------------------SGVPGTSLSSACAGPPHAPRFPASAAAAAAAAAALQRG 239

  Fly   212 VSKDPS------------------------RDKSFTCKICSRSFGYKHVLQNHERTHTGEKPFEC 252
            :...||                        |.:...|..|..:.|........::.|.      |
  Rat   240 LVLGPSDFAQYQSQIAALLQTKAPLAATARRCRRCRCPNCQAAGGAPEAEPGKKKQHV------C 298

  Fly   253 --PECHKRFTRDHHLKTHMRLHTGEKPYHCS--HCDRQFVQVANLRRHLRVHTGERPYTCEICDG 313
              |.|.|.:.:..|||.|:|.||||:|:.|:  .|.:.|.:...|:||||.||||:.:.|..|..
  Rat   299 HVPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACPECGK 363

  Fly   314 KFSDSNQLKSHMLVHNGEK 332
            :|..|:.|..|:..|..:|
  Rat   364 RFMRSDHLAKHVKTHQNKK 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr	NP_001261181.1	C2H2 Zn finger	224..244	CDD:275368	3/19 (16%)
		zf-H2C2_2	237..261	CDD:290200	5/25 (20%)
		C2H2 Zn finger	252..272	CDD:275368	9/21 (43%)
		zf-H2C2_2	264..289	CDD:290200	13/26 (50%)
		C2H2 Zn finger	280..300	CDD:275368	8/21 (38%)
		zf-H2C2_2	292..316	CDD:290200	11/23 (48%)
		C2H2 Zn finger	308..328	CDD:275368	6/19 (32%)
		zf-H2C2_2	321..345	CDD:290200	4/12 (33%)
		C2H2 Zn finger	336..352	CDD:275368
Sp5	NP_001100022.1	SP1-4_N	31..>47	CDD:425404	3/15 (20%)
		SP5_N	106..297	CDD:412096	42/212 (20%)
		C2H2 Zn finger	301..320	CDD:275368	8/18 (44%)
		COG5048	<311..384	CDD:227381	30/72 (42%)
		C2H2 Zn finger	328..350	CDD:275368	8/21 (38%)
		zf-H2C2_2	342..365	CDD:404364	11/22 (50%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000