DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Kr and BCL6B

DIOPT Version :9

Sequence 1:NP_001261181.1 Gene:Kr / 38012 FlyBaseID:FBgn0001325 Length:502 Species:Drosophila melanogaster
Sequence 2:NP_862827.2 Gene:BCL6B / 255877 HGNCID:1002 Length:479 Species:Homo sapiens


Alignment Length:344 Identity:106/344 - (30%)
Similarity:145/344 - (42%) Gaps:60/344 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 KQEDVHLD-----RSMSLSPPMSANTSATSA---AAIYPAMGLQQAAAASAFGMLSPTQLLAANR 78
            ::.:.|.|     ||.|..||..|:....:.   ...|..:..|.:.|.|..|..|..|      
Human   162 RRSEGHPDPPTESRSCSQGPPSPASPDPKACNWKKYKYIVLNSQASQAGSLVGERSSGQ------ 220

  Fly    79 QAAAFMAQLPMSTLANTLFPHNPAALFGAWAAQQSLPPQGTHLHSPPASPHSPLSTPLGSGKHPL 143
              ....|:||.                |..|:..|.....:....|...|.|.||....:.:...
Human   221 --PCPQARLPS----------------GDEASSSSSSSSSSSEEGPIPGPQSRLSPTAATVQFKC 267

  Fly   144 NSPNSTPQHHEPAKKARKLSVKKEFQTEISMSVNDMYHTSGGPIS-----PPSSGSSPNSTHDGA 203
            .:|.|||.                      :..:....|||.|..     |.|...|..:....|
Human   268 GAPASTPY----------------------LLTSQAQDTSGSPSERARPLPGSEFFSCQNCEAVA 310

  Fly   204 GGNAGCVGVSKDPSRDKSFTCKICSRSFGYKHVLQNHERTHTGEKPFECPECHKRFTRDHHLKTH 268
            |.::|...:... ..||.:.|::|..||.||..|.:|...||||||:.|..|..||.|..:||||
Human   311 GCSSGLDSLVPG-DEDKPYKCQLCRSSFRYKGNLASHRTVHTGEKPYHCSICGARFNRPANLKTH 374

  Fly   269 MRLHTGEKPYHCSHCDRQFVQVANLRRHLRVHTGERPYTCEICDGKFSDSNQLKSHMLVHNGEKP 333
            .|:|:|||||.|..|..:|||||:||.|:.:||||:||.|..|..:|.....||||:.:|.||||
Human   375 SRIHSGEKPYKCETCGSRFVQVAHLRAHVLIHTGEKPYPCPTCGTRFRHLQTLKSHVRIHTGEKP 439

  Fly   334 FECERCHMKFRRRHHLMNH 352
            :.|:.|.:.||.:..|..|
Human   440 YHCDPCGLHFRHKSQLRLH 458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KrNP_001261181.1 C2H2 Zn finger 224..244 CDD:275368 8/19 (42%)
zf-H2C2_2 237..261 CDD:290200 12/23 (52%)
C2H2 Zn finger 252..272 CDD:275368 10/19 (53%)
zf-H2C2_2 264..289 CDD:290200 14/24 (58%)
C2H2 Zn finger 280..300 CDD:275368 10/19 (53%)
zf-H2C2_2 292..316 CDD:290200 11/23 (48%)
C2H2 Zn finger 308..328 CDD:275368 7/19 (37%)
zf-H2C2_2 321..345 CDD:290200 12/23 (52%)
C2H2 Zn finger 336..352 CDD:275368 5/15 (33%)
BCL6BNP_862827.2 BTB_POZ 19..132 CDD:365784
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 143..190 8/27 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..259 15/72 (21%)
C2H2 Zn finger 330..350 CDD:275368 8/19 (42%)
COG5048 354..>411 CDD:227381 32/56 (57%)
C2H2 Zn finger 358..378 CDD:275368 10/19 (53%)
zf-H2C2_2 370..395 CDD:372612 14/24 (58%)
C2H2 Zn finger 386..406 CDD:275368 10/19 (53%)
zf-C2H2 412..434 CDD:333835 8/21 (38%)
C2H2 Zn finger 414..434 CDD:275368 7/19 (37%)
zf-H2C2_2 427..451 CDD:372612 12/23 (52%)
C2H2 Zn finger 442..460 CDD:275368 6/17 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4029
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.950

Return to query results.
Submit another query.