DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Kr and Bcl6

DIOPT Version :9

Sequence 1:NP_001261181.1 Gene:Kr / 38012 FlyBaseID:FBgn0001325 Length:502 Species:Drosophila melanogaster
Sequence 2:NP_001334955.1 Gene:Bcl6 / 12053 MGIID:107187 Length:707 Species:Mus musculus


Alignment Length:376 Identity:119/376 - (31%)
Similarity:164/376 - (43%) Gaps:73/376 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 LDRSMSLSP---------PMSANTSATSA-AAIYPAMGLQQAAAASAFGMLSPTQLLAANRQAAA 82
            |:|...:||         |.|...|.:|. |.|..|.|...|.        |||...|.|.:...
Mouse   324 LNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASGSPPAK--------SPTDPKACNWKKYK 380

  Fly    83 FMA--------------QLPMSTLANTLFPHNPAALFGAWAAQQSLPPQGTHLHSPPASPHS--- 130
            |:.              |..:..|:...:|..|       |.|..:.|....|.||.....|   
Mouse   381 FIVLNSLNQNAKPEGSEQAELGRLSPRAYPAPP-------ACQPPMEPANLDLQSPTKLSASGED 438

  Fly   131 ---PLSTPLGS--GKHPLNSPNSTPQHHEP----AKKARKLSVKKEFQTEISMSVNDMYHTSGGP 186
               |.::.|.:  .:....||.|:.:.|.|    ..|......:....||:.:      ||: ||
Mouse   439 STIPQASRLNNLVNRSLAGSPRSSSESHSPLYMHPPKCTSCGSQSPQHTEMCL------HTA-GP 496

  Fly   187 ISPPSSGSSPNSTHDGA--GGNAGC----VGVSKDPS---------RDKSFTCKICSRSFGYKHV 236
            ..|...|.:.:...|.:  .|...|    ...|::.|         .||.:.|..|..||.||..
Mouse   497 TFPEEMGETQSEYSDSSCENGTFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGN 561

  Fly   237 LQNHERTHTGEKPFECPECHKRFTRDHHLKTHMRLHTGEKPYHCSHCDRQFVQVANLRRHLRVHT 301
            |.:|:..||||||:.|..|..:|.|..:||||.|:|:|||||.|..|..:|||||:||.|:.:||
Mouse   562 LASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHT 626

  Fly   302 GERPYTCEICDGKFSDSNQLKSHMLVHNGEKPFECERCHMKFRRRHHLMNH 352
            ||:||.||||..:|.....||||:.:|.||||:.||:|::.||.:..|..|
Mouse   627 GEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLH 677

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KrNP_001261181.1 C2H2 Zn finger 224..244 CDD:275368 8/19 (42%)
zf-H2C2_2 237..261 CDD:290200 11/23 (48%)
C2H2 Zn finger 252..272 CDD:275368 9/19 (47%)
zf-H2C2_2 264..289 CDD:290200 14/24 (58%)
C2H2 Zn finger 280..300 CDD:275368 10/19 (53%)
zf-H2C2_2 292..316 CDD:290200 13/23 (57%)
C2H2 Zn finger 308..328 CDD:275368 9/19 (47%)
zf-H2C2_2 321..345 CDD:290200 13/23 (57%)
C2H2 Zn finger 336..352 CDD:275368 6/15 (40%)
Bcl6NP_001334955.1 BTB_POZ_ZBTB27_BCL6 8..125 CDD:349640
PHA03247 <179..429 CDD:223021 27/119 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 275..350 7/25 (28%)
Required for interaction with NuRD complex and for transcriptional repressor activity 377..380 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 405..469 15/70 (21%)
C2H2 Zn finger 521..542 CDD:275368 3/20 (15%)
C2H2 Zn finger 549..569 CDD:275368 8/19 (42%)
zf-H2C2_2 561..586 CDD:372612 11/24 (46%)
C2H2 Zn finger 577..597 CDD:275368 9/19 (47%)
zf-H2C2_2 589..614 CDD:372612 14/24 (58%)
C2H2 Zn finger 605..625 CDD:275368 10/19 (53%)
zf-H2C2_2 617..642 CDD:372612 14/24 (58%)
C2H2 Zn finger 633..653 CDD:275368 9/19 (47%)
zf-H2C2_2 646..670 CDD:372612 13/23 (57%)
C2H2 Zn finger 661..679 CDD:275368 7/17 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BISR
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4623
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.930

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