DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kr and bcl6

DIOPT Version :9

Sequence 1:	NP_001261181.1	Gene:	Kr / 38012	FlyBaseID:	FBgn0001325	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001116278.1	Gene:	bcl6 / 100126063	XenbaseID:	XB-GENE-984479	Length:	702	Species:	Xenopus tropicalis

Alignment Length:	284	Identity:	99/284 - (34%)
Similarity:	131/284 - (46%)	Gaps:	72/284 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 SPHSPLSTPLGSGKHPLNSPNSTPQHHEPAKKARKLSVKKEFQTEISM-----SVNDMYHTS--G 184
            ||:|  .|.|.|.:||:.|.|:..|          .|.|....||..:     .:|::.:.|  |
Frog   402 SPNS--YTSLSSYQHPVKSENADDQ----------ASPKINGSTEDPLIPQASKLNNLVNRSLEG 454

  Fly   185 GPISPPSSGSSPNSTHDG-----------------AGGNAG--------------CVG------- 211
            .|.|  |.|.||...|..                 .|.|.|              |..
Frog   455 SPQS--SEGHSPLYVHASKFNLFSSQSPPELCPHTPGSNFGEEITETQSEYSDSSCENGTFFCNE 517

  Fly   212 ----VSKDPS---------RDKSFTCKICSRSFGYKHVLQNHERTHTGEKPFECPECHKRFTRDH 263
                .|::.|         .||.:.|..|..||.||..|.:|:..||||||:.|..|..:|.|..
Frog   518 CDSRFSEEGSLKRHMLQVHSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCSICGAQFNRPA 582

  Fly   264 HLKTHMRLHTGEKPYHCSHCDRQFVQVANLRRHLRVHTGERPYTCEICDGKFSDSNQLKSHMLVH 328
            :||||.|:|:|||||.|..|..:|||||:||.|:.:||||:||.||||..:|.....||||:.:|
Frog   583 NLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIH 647

  Fly   329 NGEKPFECERCHMKFRRRHHLMNH 352
            .||||:.||:|::.||.:..|..|
Frog   648 TGEKPYHCEKCNLHFRHKSQLRLH 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr	NP_001261181.1	C2H2 Zn finger	224..244	CDD:275368	8/19 (42%)
		zf-H2C2_2	237..261	CDD:290200	11/23 (48%)
		C2H2 Zn finger	252..272	CDD:275368	9/19 (47%)
		zf-H2C2_2	264..289	CDD:290200	14/24 (58%)
		C2H2 Zn finger	280..300	CDD:275368	10/19 (53%)
		zf-H2C2_2	292..316	CDD:290200	13/23 (57%)
		C2H2 Zn finger	308..328	CDD:275368	9/19 (47%)
		zf-H2C2_2	321..345	CDD:290200	13/23 (57%)
		C2H2 Zn finger	336..352	CDD:275368	6/15 (40%)
bcl6	NP_001116278.1	BTB	24..128	CDD:279045
		BTB	35..131	CDD:197585
		C2H2 Zn finger	515..536	CDD:275368	2/20 (10%)
		C2H2 Zn finger	543..563	CDD:275368	8/19 (42%)
		zf-H2C2_2	555..580	CDD:290200	11/24 (46%)
		C2H2 Zn finger	571..591	CDD:275368	9/19 (47%)
		zf-H2C2_2	583..608	CDD:290200	14/24 (58%)
		C2H2 Zn finger	599..619	CDD:275368	10/19 (53%)
		zf-H2C2_2	611..636	CDD:290200	14/24 (58%)
		C2H2 Zn finger	627..647	CDD:275368	9/19 (47%)
		zf-H2C2_2	640..664	CDD:290200	13/23 (57%)
		C2H2 Zn finger	655..673	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4623
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030